CENPO

Protein-coding gene in the species Homo sapiens

CENPO

Identifiers

Aliases

CENPO, CENP-O, ICEN-36, MCM21R, centromere protein O

External IDs

OMIM: 611504 MGI: 1923800 HomoloGene: 49760 GeneCards: CENPO

Gene location (Human)

Chr.	Chromosome 2 (human)^[1]

Band	2p23.3	Start	24,793,136 bp^[1]
Band	2p23.3	End	24,822,376 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 12 (mouse)^[2]

Band	12 A1.1\|12 2.02 cM	Start	4,246,004 bp^[2]
Band	12 A1.1\|12 2.02 cM	End	4,284,294 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

ganglionic eminence

secondary oocyte

stromal cell of endometrium

rectum

caudate nucleus

putamen

nucleus accumbens

lymph node

prefrontal cortex

tibial nerve

Top expressed in

secondary oocyte

spermatocyte

otic placode

saccule

Paneth cell

primitive streak

cumulus cell

renal corpuscle

ureter

yolk sac

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	protein binding
Cellular component	chromosome cytosol chromosome, centromeric region kinetochore nucleoplasm nucleus Mis6-Sim4 complex
Biological process	centromere complex assembly CENP-A containing chromatin assembly
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


79172


52504

Ensembl


ENSG00000138092


ENSMUSG00000020652

UniProt


Q9BU64


Q8K015

RefSeq (mRNA)


NM_001199803 NM_024322 NM_001322101


NM_134046 NM_001361641

RefSeq (protein)


NP_001186732 NP_001309030 NP_077298


NP_598807 NP_001348570

Location (UCSC)

Chr 2: 24.79 – 24.82 Mb

Chr 12: 4.25 – 4.28 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Centromere protein O is a protein that in humans is encoded by the CENPO gene.^[5]^[6]^[7] CENPO is involved in cell proliferation and cell cycle progression and has been shown to be down-regulated in trisomic neurospheres a mouse model of Down Syndrome, resulting in reduced numbers of neural progenitors and neuroblasts and a severe reduction in numbers of neurons produced. ^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000138092 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020652 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Okada M, Cheeseman IM, Hori T, Okawa K, McLeod IX, Yates JR 3rd, Desai A, Fukagawa T (May 2006). "The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres". Nat Cell Biol. 8 (5): 446–57. doi:10.1038/ncb1396. PMID 16622420. S2CID 26974412.
^ Foltz DR, Jansen LE, Black BE, Bailey AO, Yates JR 3rd, Cleveland DW (May 2006). "The human CENP-A centromeric nucleosome-associated complex". Nat Cell Biol. 8 (5): 458–69. doi:10.1038/ncb1397. PMID 16622419. S2CID 205286556.
^ "Entrez Gene: CENPO centromere protein O".
^ Hewitt, Chelsee A.; Ling, King-Hwa; Merson, Tobias D.; Simpson, Ken M.; Ritchie, Matthew E.; King, Sarah L.; Pritchard, Melanie A.; Smyth, Gordon K.; Thomas, Tim (2010-07-16). "Gene Network Disruptions and Neurogenesis Defects in the Adult Ts1Cje Mouse Model of Down Syndrome". PLOS ONE. 5 (7): e11561. Bibcode:2010PLoSO...511561H. doi:10.1371/journal.pone.0011561. ISSN 1932-6203. PMC 2905390. PMID 20661276.

External links

Human CENPO genome location and CENPO gene details page in the UCSC Genome Browser.

Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Obuse C, Yang H, Nozaki N, et al. (2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase". Genes Cells. 9 (2): 105–20. doi:10.1111/j.1365-2443.2004.00705.x. PMID 15009096. S2CID 21813024.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Izuta H, Ikeno M, Suzuki N, et al. (2006). "Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells". Genes Cells. 11 (6): 673–84. doi:10.1111/j.1365-2443.2006.00969.x. PMID 16716197. S2CID 45931410.