Protein-coding gene in the species Homo sapiens
| ESM1 |
|---|
|
| Identifiers |
|---|
| Aliases | ESM1, endocan, endothelial cell specific molecule 1 |
|---|
| External IDs | OMIM: 601521; MGI: 1918940; HomoloGene: 5107; GeneCards: ESM1; OMA:ESM1 - orthologs |
|---|
| Gene location (Human) |
|---|
 | | Chr. | Chromosome 5 (human)[1] |
|---|
| | Band | 5q11.2 | Start | 54,977,867 bp[1] |
|---|
| End | 55,022,671 bp[1] |
|---|
|
| Gene location (Mouse) |
|---|
 | | Chr. | Chromosome 13 (mouse)[2] |
|---|
| | Band | 13|13 D2.2 | Start | 113,346,193 bp[2] |
|---|
| End | 113,354,632 bp[2] |
|---|
|
| RNA expression pattern |
|---|
| Bgee | | Human | Mouse (ortholog) |
|---|
| Top expressed in | - islet of Langerhans
- right lung
- testicle
- trabecular bone
- upper lobe of left lung
- human kidney
- lower lobe of lung
- renal cortex
- visceral pleura
- tibia
|
| | Top expressed in | - pineal gland
- islet of Langerhans
- right kidney
- stroma of bone marrow
- human kidney
- adrenal gland
- pituitary gland
- proximal tubule
- extraocular muscle
- renal corpuscle
|
| | More reference expression data |
|
|---|
| BioGPS |  | | More reference expression data |
|
|---|
|
| Gene ontology |
|---|
| Molecular function | - integrin binding
- insulin-like growth factor binding
- hepatocyte growth factor receptor binding
| | Cellular component | | | Biological process | - sprouting angiogenesis
- regulation of cell growth
- angiogenesis
- positive regulation of cell population proliferation
- positive regulation of hepatocyte growth factor receptor signaling pathway
| | Sources:Amigo / QuickGO |
|
| Orthologs |
|---|
| Species | Human | Mouse |
|---|
| Entrez | | |
|---|
| Ensembl | | |
|---|
| UniProt | | |
|---|
| RefSeq (mRNA) | | |
|---|
| RefSeq (protein) | | |
|---|
| Location (UCSC) | Chr 5: 54.98 – 55.02 Mb | Chr 13: 113.35 – 113.35 Mb |
|---|
| PubMed search | [3] | [4] |
|---|
|
| Wikidata |
| View/Edit Human | View/Edit Mouse |
|
Endothelial cell-specific molecule 1 is a protein that in humans is encoded by the ESM1 gene.[5][6]
This gene encodes a secreted protein which is mainly expressed in the endothelial cells in human lung and kidney tissues. The expression of this gene is regulated by cytokines, suggesting that it may play a role in endothelium-dependent pathological disorders. The transcript contains multiple polyadenylation and mRNA instability signals.[6]
The ESM-1 gene product is also called endocan since 2001, when it was characterized as a dermatan sulfate proteoglycan by Bechard et al. Recently, endocan / ESM-1 has been described as a specific biomarker of tip cells during neoangiogenesis by independent teams. Endocan expression has been shown to be increase in presence of pro-angiogenic growth factors such as vascular endothelial growth factor (VEGF) or fibroblast growth factor 2 (FGF-2). In hypervascularized cancers, overexpression of endocan has been detected by immunohistochemistry using monoclonal antibodies against endocan / ESM-1.
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000164283 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000042379 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Lassalle P, Molet S, Janin A, Heyden JV, Tavernier J, Fiers W, Devos R, Tonnel AB (Oct 1996). "ESM-1 is a novel human endothelial cell-specific molecule expressed in lung and regulated by cytokines". J Biol Chem. 271 (34): 20458–64. doi:10.1074/jbc.271.34.20458. PMID 8702785.
- ^ a b "Entrez Gene: ESM1 endothelial cell-specific molecule 1".
Further reading
- Bechard D, Meignin V, Scherpereel A, et al. (2000). "Characterization of the secreted form of endothelial-cell-specific molecule 1 by specific monoclonal antibodies". J. Vasc. Res. 37 (5): 417–25. doi:10.1159/000025758. PMID 11025405. S2CID 22931177.
- Béchard D, Scherpereel A, Hammad H, et al. (2001). "Human endothelial-cell specific molecule-1 binds directly to the integrin CD11a/CD18 (LFA-1) and blocks binding to intercellular adhesion molecule-1". J. Immunol. 167 (6): 3099–106. doi:10.4049/jimmunol.167.6.3099. PMID 11544294.
- Aitkenhead M, Wang SJ, Nakatsu MN, et al. (2002). "Identification of endothelial cell genes expressed in an in vitro model of angiogenesis: induction of ESM-1, (beta)ig-h3, and NrCAM". Microvascular Research. 63 (2): 159–71. doi:10.1006/mvre.2001.2380. PMID 11866539.
- Tsai JC, Zhang J, Minami T, et al. (2002). "Cloning and characterization of the human lung endothelial-cell-specific molecule-1 promoter". J. Vasc. Res. 39 (2): 148–59. doi:10.1159/000057763. PMID 12011586. S2CID 40049627.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Wellner M, Herse F, Janke J, et al. (2004). "Endothelial cell specific molecule-1--a newly identified protein in adipocytes". Horm. Metab. Res. 35 (4): 217–21. doi:10.1055/s-2003-39477. PMID 12778364. S2CID 22500788.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
- Cong R, Jiang X, Wilson CM, et al. (2006). "Hhex is a direct repressor of endothelial cell-specific molecule 1 (ESM-1)". Biochem. Biophys. Res. Commun. 346 (2): 535–45. doi:10.1016/j.bbrc.2006.05.153. PMID 16764824.
- Grigoriu BD, Depontieu F, Scherpereel A, et al. (2007). "Endocan expression and relationship with survival in human non-small cell lung cancer". Clin. Cancer Res. 12 (15): 4575–82. doi:10.1158/1078-0432.CCR-06-0185. PMID 16899604.
- Rennel E, Mellberg S, Dimberg A, et al. (2007). "Endocan is a VEGF-A and PI3K regulated gene with increased expression in human renal cancer". Exp. Cell Res. 313 (7): 1285–94. doi:10.1016/j.yexcr.2007.01.021. PMID 17362927.
