GSTT1

Protein-coding gene in the species Homo sapiens
GSTT1
Available structures
PDBHuman UniProt search: PDBe RCSB
List of PDB id codes

2C3N, 2C3Q, 2C3T

Identifiers
AliasesGSTT1, glutathione S-transferase theta 1
External IDsOMIM: 600436 GeneCards: GSTT1
Gene location (Human)
Chromosome 22 (human)
Chr.Chromosome 22 (human)
Chromosome 22 (human)
Genomic location for GSTT1
Genomic location for GSTT1
Band22q11.23Start24,376,133 bp
End24,384,680 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • vena cava

  • thoracic diaphragm

  • adrenal gland

  • external globus pallidus

  • jejunal mucosa

  • right ventricle

  • coronary artery

  • cingulate gyrus

  • vastus lateralis muscle

  • cerebellar vermis
    n/a
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • transferase activity
  • glutathione peroxidase activity
  • glutathione transferase activity
  • protein binding
Cellular component
  • cytoplasm
  • cytosol
  • extracellular exosome
Biological process
  • glutathione derivative biosynthetic process
  • glutathione metabolic process
  • cellular oxidant detoxification
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

2952

n/a

Ensembl

ENSG00000277656

n/a

UniProt

P30711

n/a

RefSeq (mRNA)
NM_000853
NM_001293807
NM_001293808
NM_001293809
NM_001293810

NM_001293811
NM_001293812
NM_001293813
NM_001293814

n/a

RefSeq (protein)
NP_000844
NP_001280736
NP_001280737
NP_001280738
NP_001280739

NP_001280740
NP_001280741
NP_001280742
NP_001280743

n/a

Location (UCSC)Chr 22: 24.38 – 24.38 Mbn/a
PubMed search[1]n/a
Wikidata
View/Edit Human

Glutathione S-transferase theta-1 is an enzyme that in humans is encoded by the GSTT1 gene.[2]

Glutathione S-transferase (GST) theta 1 (GSTT1) is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1 and GSTT2. The GSTT1 and GSTT2 share 55% amino acid sequence identity and both of them were claimed to have an important role in human carcinogenesis. The GSTT1 gene is located approximately 50kb away from the GSTT2 gene. The GSTT1 and GSTT2 genes have a similar structure, being composed of five exons with identical exon/intron boundaries.[3]


References

  1. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  2. ^ Webb G, Vaska V, Coggan M, Board P (Jun 1996). "Chromosomal localization of the gene for the human theta class glutathione transferase (GSTT1)". Genomics. 33 (1): 121–3. doi:10.1006/geno.1996.0167. PMID 8617495.
  3. ^ "Entrez Gene: GSTT1 glutathione S-transferase theta 1".
  • v
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  • 2c3n: HUMAN GLUTATHIONE-S-TRANSFERASE T1-1, APO FORM
    2c3n: HUMAN GLUTATHIONE-S-TRANSFERASE T1-1, APO FORM
  • 2c3q: HUMAN GLUTATHIONE-S-TRANSFERASE T1-1 W234R MUTANT, COMPLEX WITH S-HEXYLGLUTATHIONE
    2c3q: HUMAN GLUTATHIONE-S-TRANSFERASE T1-1 W234R MUTANT, COMPLEX WITH S-HEXYLGLUTATHIONE
  • 2c3t: HUMAN GLUTATHIONE-S-TRANSFERASE T1-1, W234R MUTANT, APO FORM
    2c3t: HUMAN GLUTATHIONE-S-TRANSFERASE T1-1, W234R MUTANT, APO FORM
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