Motile sperm domain containing 2

Protein-coding gene in the species Homo sapiens

MOSPD2

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
1WIC

Identifiers

Aliases

MOSPD2, Motile sperm domain containing 2

External IDs

MGI: 1924013 HomoloGene: 22125 GeneCards: MOSPD2

Gene location (Human)

Chr.	X chromosome (human)^[1]

Band	Xp22.2	Start	14,873,421 bp^[1]
Band	Xp22.2	End	14,922,327 bp^[1]

Gene location (Mouse)

Chr.	X chromosome (mouse)^[2]

Band	X\|X F5	Start	163,719,165 bp^[2]
Band	X\|X F5	End	163,763,371 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

secondary oocyte

corpus callosum

inferior ganglion of vagus nerve

monocyte

subthalamic nucleus

visceral pleura

blood

pons

superior vestibular nucleus

ventral tegmental area

Top expressed in

parotid gland

carotid body

ciliary body

sciatic nerve

iris

left lung lobe

conjunctival fornix

seminal vesicula

calvaria

submandibular gland

More reference expression data

BioGPS

n/a

Orthologs

Species

Human

Mouse

Entrez


158747


76763

Ensembl


ENSG00000130150


ENSMUSG00000061778

UniProt


Q8NHP6


Q9CWP6

RefSeq (mRNA)


NM_001177475 NM_152581 NM_001330241


NM_001290523 NM_001290524 NM_029730

RefSeq (protein)


NP_001170946 NP_001317170 NP_689794


NP_001277452 NP_001277453 NP_084006

Location (UCSC)

Chr X: 14.87 – 14.92 Mb

Chr X: 163.72 – 163.76 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Motile sperm domain containing 2 is a protein that in humans is encoded by the MOSPD2 gene.^[5] It is an endoplasmic reticulum–resident protein involved in membrane contact site formation.^[6] Its domain homologous to Major Sperm Protein (MSP domain) is very similar to VAPA/VAPB, so it has been described as the third human member of the VAP protein family.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000130150 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000061778 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Motile sperm domain containing 2".
^ Di Mattia T, Wilhelm LP, Ikhlef S, Wendling C, Spehner D, Nominé Y, Giordano F, Mathelin C, Drin G, Tomasetto C, Alpy F (June 2018). "Identification of MOSPD2, a novel scaffold for endoplasmic reticulum membrane contact sites". EMBO Reports. 19 (7): e45453. doi:10.15252/embr.201745453. PMC 6030701. PMID 29858488.