Opaganib

Chemical compound

Investigational new drug

Identifiers

IUPAC name

3-(4-chlorophenyl)-N-(pyridin-4-ylmethyl)adamantane-1-carboxamide

CAS Number

915385-81-8

PubChem CID

15604015

DrugBank

12764

ChemSpider

13079494

UNII

DRG21OQ517

ChEBI

CHEBI:124965

ChEMBL

ChEMBL2158685

CompTox Dashboard (EPA)

DTXSID801318727

Chemical and physical dataFormulaC₂₃H₂₅ClN₂OMolar mass380.92 g·mol⁻¹3D model (JSmol)

Interactive image

SMILES

C1C2CC3(CC1CC(C2)(C3)C(=O)NCC4=CC=NC=C4)C5=CC=C(C=C5)Cl

InChI

InChI=1S/C23H25ClN2O/c24-20-3-1-19(2-4-20)22-10-17-9-18(11-22)13-23(12-17,15-22)21(27)26-14-16-5-7-25-8-6-16/h1-8,17-18H,9-15H2,(H,26,27)
Key:CAOTVXGYTWCKQE-UHFFFAOYSA-N

Opaganib (ABC294640) is a drug which acts as an inhibitor of the enzyme sphingosine kinase 2. It is under development as a potential treatment agent for several different kinds of cancer.^[1]^[2]

References

^ Camp ER, Patterson LD, Kester M, Voelkel-Johnson C (September 2017). "Therapeutic implications of bioactive sphingolipids: A focus on colorectal cancer". Cancer Biology & Therapy. 18 (9): 640–650. doi:10.1080/15384047.2017.1345396. PMC 5663409. PMID 28686076.
^ Lewis CS, Voelkel-Johnson C, Smith CD (2018). "Targeting Sphingosine Kinases for the Treatment of Cancer". Advances in Cancer Research. 140: 295–325. doi:10.1016/bs.acr.2018.04.015. ISBN 9780128142233. PMC 6447312. PMID 30060814.