Protein-coding gene in the species Homo sapiens
RNASE6 |
---|
|
Available structures |
---|
PDB | Ortholog search: PDBe RCSB |
---|
|
|
Identifiers |
---|
Aliases | RNASE6, RAD1, RNS6, RNasek6, ribonuclease A family member k6 |
---|
External IDs | OMIM: 601981; MGI: 1925666; HomoloGene: 4102; GeneCards: RNASE6; OMA:RNASE6 - orthologs |
---|
Gene location (Human) |
---|
![Chromosome 14 (human)](//upload.wikimedia.org/wikipedia/commons/thumb/7/78/Ideogram_human_chromosome_14.svg/300px-Ideogram_human_chromosome_14.svg.png) | Chr. | Chromosome 14 (human)[1] |
---|
| Band | 14q11.2 | Start | 20,781,268 bp[1] |
---|
End | 20,782,467 bp[1] |
---|
|
Gene location (Mouse) |
---|
![Chromosome 14 (mouse)](//upload.wikimedia.org/wikipedia/commons/thumb/e/e5/Ideogram_house_mouse_chromosome_14.svg/260px-Ideogram_house_mouse_chromosome_14.svg.png) | Chr. | Chromosome 14 (mouse)[2] |
---|
| Band | 14|14 C1 | Start | 51,361,365 bp[2] |
---|
End | 51,369,644 bp[2] |
---|
|
RNA expression pattern |
---|
Bgee | Human | Mouse (ortholog) |
---|
Top expressed in | - monocyte
- granulocyte
- spleen
- blood
- gallbladder
- lymph node
- testicle
- appendix
- right coronary artery
- rectum
|
| Top expressed in | - mesenteric lymph nodes
- spleen
- zygote
- primary oocyte
- granulocyte
- embryo
- secondary oocyte
- blood
- embryo
- bone marrow
|
| More reference expression data |
|
---|
BioGPS | |
---|
|
Gene ontology |
---|
Molecular function | - nuclease activity
- endonuclease activity
- hydrolase activity
- nucleic acid binding
- ribonuclease activity
| Cellular component | - extracellular region
- extracellular space
- intracellular anatomical structure
- cytoplasmic vesicle
- lysosome
| Biological process | - defense response
- RNA catabolic process
- antimicrobial humoral response
- antibacterial humoral response
- innate immune response
- defense response to virus
- antimicrobial humoral immune response mediated by antimicrobial peptide
- RNA phosphodiester bond hydrolysis
- defense response to bacterium
- nucleic acid phosphodiester bond hydrolysis
| Sources:Amigo / QuickGO |
|
|
Wikidata |
View/Edit Human | View/Edit Mouse |
|
Ribonuclease A family member k6 is a protein that in humans is encoded by the RNASE6 gene. [5]
Function
The protein encoded by this gene is a member of the ribonuclease A superfamily and functions in the urinary tract. The protein has broad-spectrum antimicrobial activity against pathogenic bacteria. [provided by RefSeq, Nov 2014].
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000169413 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021880 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Ribonuclease A family member k6". Retrieved 2018-02-21.
Further reading
- Becknell B, Eichler TE, Beceiro S, Li B, Easterling RS, Carpenter AR, James CL, McHugh KM, Hains DS, Partida-Sanchez S, Spencer JD (January 2015). "Ribonucleases 6 and 7 have antimicrobial function in the human and murine urinary tract". Kidney Int. 87 (1): 151–61. doi:10.1038/ki.2014.268. PMC 4281292. PMID 25075772.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.