RNASE6

Protein-coding gene in the species Homo sapiens
RNASE6
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

4X09

Identifiers
AliasesRNASE6, RAD1, RNS6, RNasek6, ribonuclease A family member k6
External IDsOMIM: 601981; MGI: 1925666; HomoloGene: 4102; GeneCards: RNASE6; OMA:RNASE6 - orthologs
Gene location (Human)
Chromosome 14 (human)
Chr.Chromosome 14 (human)[1]
Chromosome 14 (human)
Genomic location for RNASE6
Genomic location for RNASE6
Band14q11.2Start20,781,268 bp[1]
End20,782,467 bp[1]
Gene location (Mouse)
Chromosome 14 (mouse)
Chr.Chromosome 14 (mouse)[2]
Chromosome 14 (mouse)
Genomic location for RNASE6
Genomic location for RNASE6
Band14|14 C1Start51,361,365 bp[2]
End51,369,644 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • monocyte

  • granulocyte

  • spleen

  • blood

  • gallbladder

  • lymph node

  • testicle

  • appendix

  • right coronary artery

  • rectum
Top expressed in
  • mesenteric lymph nodes

  • spleen

  • zygote

  • primary oocyte

  • granulocyte

  • embryo

  • secondary oocyte

  • blood

  • embryo

  • bone marrow
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • nuclease activity
  • endonuclease activity
  • hydrolase activity
  • nucleic acid binding
  • ribonuclease activity
Cellular component
  • extracellular region
  • extracellular space
  • intracellular anatomical structure
  • cytoplasmic vesicle
  • lysosome
Biological process
  • defense response
  • RNA catabolic process
  • antimicrobial humoral response
  • antibacterial humoral response
  • innate immune response
  • defense response to virus
  • antimicrobial humoral immune response mediated by antimicrobial peptide
  • RNA phosphodiester bond hydrolysis
  • defense response to bacterium
  • nucleic acid phosphodiester bond hydrolysis
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

6039

78416

Ensembl

ENSG00000169413

ENSMUSG00000021880

UniProt

Q93091
Q6IB39

Q9D244

RefSeq (mRNA)

NM_005615

NM_030098
NM_001360117

RefSeq (protein)

NP_005606
NP_005606.1

NP_084374
NP_001347046

Location (UCSC)Chr 14: 20.78 – 20.78 MbChr 14: 51.36 – 51.37 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ribonuclease A family member k6 is a protein that in humans is encoded by the RNASE6 gene. [5]

Function

The protein encoded by this gene is a member of the ribonuclease A superfamily and functions in the urinary tract. The protein has broad-spectrum antimicrobial activity against pathogenic bacteria. [provided by RefSeq, Nov 2014].

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000169413 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021880 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Ribonuclease A family member k6". Retrieved 2018-02-21.

Further reading

  • Becknell B, Eichler TE, Beceiro S, Li B, Easterling RS, Carpenter AR, James CL, McHugh KM, Hains DS, Partida-Sanchez S, Spencer JD (January 2015). "Ribonucleases 6 and 7 have antimicrobial function in the human and murine urinary tract". Kidney Int. 87 (1): 151–61. doi:10.1038/ki.2014.268. PMC 4281292. PMID 25075772.


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This article incorporates text from the United States National Library of Medicine, which is in the public domain.