TECTB

Protein-coding gene in the species Homo sapiens
TECTB
Identifiers
AliasesTECTB, tectorin beta
External IDsOMIM: 602653 MGI: 109574 HomoloGene: 7568 GeneCards: TECTB
Gene location (Human)
Chromosome 10 (human)
Chr.Chromosome 10 (human)[1]
Chromosome 10 (human)
Genomic location for TECTB
Genomic location for TECTB
Band10q25.2Start112,283,400 bp[1]
End112,305,038 bp[1]
Gene location (Mouse)
Chromosome 19 (mouse)
Chr.Chromosome 19 (mouse)[2]
Chromosome 19 (mouse)
Genomic location for TECTB
Genomic location for TECTB
Band19 D2|19 51.13 cMStart55,169,165 bp[2]
End55,184,745 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • retinal pigment epithelium

  • liver

  • right lobe of liver

  • right lobe of thyroid gland

  • putamen

  • temporal lobe

  • mesencephalon

  • left lobe of thyroid gland

  • substantia nigra

  • caudate nucleus
Top expressed in
  • organ of Corti

  • utricle

  • cochlea

  • saccule

  • stria vascularis

  • brown adipose tissue

  • white adipose tissue

  • esophagus

  • stomach
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • extracellular matrix structural constituent
Cellular component
  • anchored component of membrane
  • membrane
  • extracellular region
  • plasma membrane
  • extracellular matrix
Biological process
  • C-terminal protein lipidation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

6975

21684

Ensembl

ENSG00000119913

ENSMUSG00000024979

UniProt

Q96PL2

O08524

RefSeq (mRNA)

NM_058222

NM_009348

RefSeq (protein)

NP_478129

NP_033374

Location (UCSC)Chr 10: 112.28 – 112.31 MbChr 19: 55.17 – 55.18 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Beta-tectorin is a protein that in humans is encoded by the TECTB gene.[5]

Function

The genes for alpha-tectorin and beta-tectorin (this protein) encode the major noncollagenous proteins of the tectorial membrane of the cochlea.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000119913 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024979 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: tectorin beta".

Further reading

  • Legan PK, Rau A, Keen JN, Richardson GP (1997). "The mouse tectorins. Modular matrix proteins of the inner ear homologous to components of the sperm-egg adhesion system". J. Biol. Chem. 272 (13): 8791–801. doi:10.1074/jbc.272.13.8791. PMID 9079715.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi:10.1038/nature02462. PMID 15164054.
  • Rose JE, Behm FM, Drgon T, et al. (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Grupe A, Li Y, Rowland C, et al. (2006). "A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease". Am. J. Hum. Genet. 78 (1): 78–88. doi:10.1086/498851. PMC 1380225. PMID 16385451.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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Extracellular
matrix
Collagen
Fibril forming
Other
Enzymes
Laminin
Other
Other


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