Toxopyrimidine

Toxopyrimidine
Names


Preferred IUPAC name (4-Amino-2-methylpyrimidin-5-yl)methanol
Other names Pyramin^[1]
Identifiers
CAS Number	73-67-6
3D model (JSmol)	Interactive image
ChemSpider	756
ECHA InfoCard	100.234.283
PubChem CID	777
UNII	G62V17J09J
CompTox Dashboard (EPA)	DTXSID80223275
InChI InChI=1S/C6H9N3O/c1-4-8-2-5(3-10)6(7)9-4/h2,10H,3H2,1H3,(H2,7,8,9) Key: VUTBELPREDJDDH-UHFFFAOYSA-N
SMILES Cc1ncc(c(n1)N)CO
Properties
Chemical formula	C₆H₉N₃O
Molar mass	139.158 g·mol⁻¹
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Chemical compound

Toxopyrimidine is a vitamin B₆ antagonist with potent convulsant effects.^[2]^[3]

References

^ Haughton BG, King HK (December 1958). "Toxo-pyrimidine phosphate as an inhibitor of bacterial enzyme systems that require pyridoxal phosphate". The Biochemical Journal. 70 (4): 660–5. doi:10.1042/bj0700660. PMC 1196724. PMID 13607425.
^ Rindi G, Ferrari G (February 1959). "The gamma-aminobutyric acid and glutamic acid content of brains of rats treated with toxopyrimidine". Nature. 183 (4661): 608–9. Bibcode:1959Natur.183..608R. doi:10.1038/183608a0. PMID 13632808. S2CID 4200644.
^ Rindi G, Perri V, Ventura U (April 1959). "Effect of toxopyrimidine on glutamic-decarboxylase and glutamic-oxalacetic transaminase of rat brain". Nature. 183 (4668): 1126–7. Bibcode:1959Natur.183.1126R. doi:10.1038/1831126a0. PMID 13657025. S2CID 4209134.

Neurotoxins

Animal toxins

Cholinergic neurotoxins

Other

v t e Convulsants
GABA receptor antagonists	Bicuculline Bicyclic phosphates (TBPS, TBPO, IPTBO) BIDN Chlorophenylsilatrane Cicutoxin Cloflubicyne Coriamyrtin Dihydropicrotoxinin DMCM EBOB Endosulfan FG-7142 Fipronil Flurothyl Gabazine Oenanthotoxin Pentylenetetrazol Phenylsilatrane Picrotoxin p-CN-TBOB p-NCS-TBOB RDX TBOB Tetramethylenedisulfotetramine Thujone Trimethylolpropane phosphite Tutin
GABA synthesis inhibitors	3-Mercaptopropionic acid 4-Deoxypyridoxine Allylglycine Crimidine Decaborane Ginkgotoxin Isoniazid Pentaborane Thiocarbohydrazide Toxopyrimidine
Glycine receptor antagonists	Coriamyrtin Dendrobine Picrotoxin Strychnine Tutin
Glutamate receptor agonists	AMPA Domoic acid Kainic acid NMDA Quisqualic acid Tetrazolylglycine
Convulsant barbiturates	CHEB DMBB McN-481
Other	2,2,3,3-Tetrafluoropropyl trifluoromethyl ether Bromocamphor Camphor FAZ-4 Fluoroethyl fluoroacetate MC-2973 Methionine sulfoximine Methyl fluoroacetate Nitrocyclohexane Thebaine