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EA-2192

EA-2192
Names
Preferred IUPAC name
S-{2-[Di(propan-2-yl)amino]ethyl} methylphosphonothioate
Other names
Diisopropylaminoethyl methyl thiolophosphonate
Identifiers
3D model (JSmol)
ChemSpider
UNII
  • CC(C)N(CCSP(=O)(C)O)C(C)C
Properties
C9H22NO2PS
Molar mass 239.31 g·mol−1
Appearance White solid
Very soluble
Hazards
Occupational safety and health (OHS/OSH):
Main hazards
 Extremely toxic
Lethal dose or concentration (LD, LC):
630 μg/kg (Rat, oral)
18 μg/kg (Rat, iv)
50 μg/kg (Mouse, iv)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

EA-2192 is an extremely toxic degradation product of the VX, a very potent nerve agent.[1][2] It is a white solid that is very soluble and stable in water.

EA-2192 is an extremely potent acetylcholinesterase inhibitor. It is almost as toxic as VX itself.[3]

EA-2192 instantly ages acetylcholinesterase as it is the dealkylated form of VX and can also not be reversed with common oxime reactivators.[4]

EA-2192 from VX

See also

[edit]

References

[edit]
  1. ^ Ellison, D. Hank (2007). Handbook of chemical and biological warfare agents (2nd ed.). Boca Raton, Fla.: CRC. ISBN 9780849314346.
  2. ^ Hoenig, Steven L. (2007), Compendium of Chemical Warfare Agents, Springer, ISBN 978-0-387-34626-7
  3. ^ Munro, NB; Talmage, SS; Griffin, GD; Waters, LC; Watson, AP; King, JF; Hauschild, V (December 1999). "The sources, fate, and toxicity of chemical warfare agent degradation products". Environmental Health Perspectives. 107 (12): 933–74. Bibcode:1999EnvHP.107..933M. doi:10.1289/ehp.99107933. PMC 1566810. PMID 10585900.
  4. ^ Reiter, Georg; Mikler, John; Hill, Ira; Weatherby, Kendal; Thiermann, Horst; Worek, Franz (2011). "Simultaneous quantification of VX and its toxic metabolite in blood and plasma samples and its application for in vivo and in vitro toxicological studies". Journal of Chromatography B. 879 (26): 2704–2713. doi:10.1016/j.jchromb.2011.07.031. Retrieved 2025-07-17.
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