SPPL3 |
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Identifiers |
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Aliases | SPPL3, IMP2, MDHV1887, PRO4332, PSH1, PSL4, UNQ1887, signal peptide peptidase like 3 |
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External IDs | OMIM: 608240; MGI: 1891433; HomoloGene: 15563; GeneCards: SPPL3; OMA:SPPL3 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 12 (human)[1] |
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| Band | 12q24.31 | Start | 120,762,510 bp[1] |
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End | 120,904,358 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 5 (mouse)[2] |
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| Band | 5|5 F | Start | 115,149,196 bp[2] |
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End | 115,236,849 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - skin of arm
- skin of leg
- mucosa of ileum
- nipple
- skin of abdomen
- skin of thigh
- skin of hip
- secondary oocyte
- mucosa of esophagus
- human penis
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| Top expressed in | - cumulus cell
- corneal stroma
- Ileal epithelium
- lip
- hair follicle
- CA3 field
- conjunctival fornix
- perirhinal cortex
- entorhinal cortex
- ciliary body
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| More reference expression data |
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BioGPS | |
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Gene ontology |
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Molecular function | - protein homodimerization activity
- aspartic-type endopeptidase activity
- aspartic endopeptidase activity, intramembrane cleaving
- peptidase activity
- protein binding
- hydrolase activity
| Cellular component | - integral component of membrane
- rough endoplasmic reticulum
- Golgi apparatus
- endoplasmic reticulum membrane
- membrane
- intracellular membrane-bounded organelle
- integral component of cytoplasmic side of endoplasmic reticulum membrane
- plasma membrane
- endoplasmic reticulum
- Golgi-associated vesicle membrane
- integral component of lumenal side of endoplasmic reticulum membrane
- endoplasmic reticulum-Golgi intermediate compartment membrane
- lysosomal membrane
| Biological process | - positive regulation of protein dephosphorylation
- membrane protein proteolysis
- positive regulation of cytosolic calcium ion concentration
- proteolysis
- membrane protein ectodomain proteolysis
- positive regulation of protein binding
- T cell receptor signaling pathway
- positive regulation of calcineurin-NFAT signaling cascade
- signal peptide processing
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Location (UCSC) | Chr 12: 120.76 – 120.9 Mb | Chr 5: 115.15 – 115.24 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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