USP8

Protein-coding gene in the species Homo sapiens
USP8
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1WHB, 2A9U, 2GFO, 2GWF, 3N3K

Identifiers
AliasesUSP8, HumORF8, SPG59, UBPY, ubiquitin specific peptidase 8, PITA4
External IDsOMIM: 603158 MGI: 1934029 HomoloGene: 3782 GeneCards: USP8
Gene location (Human)
Chromosome 15 (human)
Chr.Chromosome 15 (human)[1]
Chromosome 15 (human)
Genomic location for USP8
Genomic location for USP8
Band15q21.2Start50,424,380 bp[1]
End50,514,421 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for USP8
Genomic location for USP8
Band2|2 F1Start126,549,248 bp[2]
End126,601,217 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • Achilles tendon

  • sural nerve

  • rectum

  • monocyte

  • caput epididymis

  • corpus epididymis

  • gallbladder

  • islet of Langerhans

  • stromal cell of endometrium

  • jejunal mucosa
Top expressed in
  • spermatid

  • seminiferous tubule

  • spermatocyte

  • medial vestibular nucleus

  • proximal tubule

  • kidney

  • dorsomedial hypothalamic nucleus

  • seminal vesicula

  • brown adipose tissue

  • left lung
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • cysteine-type peptidase activity
  • SH3 domain binding
  • thiol-dependent deubiquitinase
  • peptidase activity
  • protein binding
  • cysteine-type endopeptidase activity
  • hydrolase activity
  • cadherin binding
Cellular component
  • cytoplasm
  • endosome
  • membrane
  • plasma membrane
  • extrinsic component of endosome membrane
  • midbody
  • endosome membrane
  • extrinsic component of plasma membrane
  • nucleus
  • postsynaptic density
  • dendritic spine
  • early endosome
  • cytosol
  • glutamatergic synapse
Biological process
  • protein K48-linked deubiquitination
  • ubiquitin-dependent protein catabolic process
  • mitotic cytokinesis
  • endosome organization
  • proteolysis
  • protein K63-linked deubiquitination
  • cell cycle
  • cell population proliferation
  • protein deubiquitination
  • cellular response to dexamethasone stimulus
  • cellular response to nerve growth factor stimulus
  • positive regulation of canonical Wnt signaling pathway
  • Ras protein signal transduction
  • regulation of protein stability
  • regulation of protein localization
  • regulation of protein catabolic process at postsynapse, modulating synaptic transmission
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9101

84092

Ensembl

ENSG00000138592

ENSMUSG00000027363

UniProt

P40818

Q80U87

RefSeq (mRNA)

NM_001128610
NM_001128611
NM_001283049
NM_005154

NM_001252580
NM_019729

RefSeq (protein)

NP_001122082
NP_001269978
NP_005145

NP_001239509
NP_062703

Location (UCSC)Chr 15: 50.42 – 50.51 MbChr 2: 126.55 – 126.6 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ubiquitin carboxyl-terminal hydrolase 8 is an enzyme that in humans is encoded by the USP8 gene.[5][6][7]

Interactions

USP8 has been shown to interact with RNF41[8] and STAM2.[9][10]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000138592 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027363 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Puente XS, Sánchez LM, Overall CM, López-Otín C (July 2003). "Human and mouse proteases: a comparative genomic approach". Nature Reviews. Genetics. 4 (7): 544–58. doi:10.1038/nrg1111. PMID 12838346. S2CID 2856065.
  6. ^ Janssen JW, Schleithoff L, Bartram CR, Schulz AS (April 1998). "An oncogenic fusion product of the phosphatidylinositol 3-kinase p85beta subunit and HUMORF8, a putative deubiquitinating enzyme". Oncogene. 16 (13): 1767–72. doi:10.1038/sj.onc.1201695. PMID 9582025.
  7. ^ "Entrez Gene: USP8 ubiquitin specific peptidase 8".
  8. ^ Wu X, Yen L, Irwin L, Sweeney C, Carraway KL (September 2004). "Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8". Molecular and Cellular Biology. 24 (17): 7748–57. doi:10.1128/MCB.24.17.7748-7757.2004. PMC 506982. PMID 15314180.
  9. ^ Kaneko T, Kumasaka T, Ganbe T, Sato T, Miyazawa K, Kitamura N, Tanaka N (November 2003). "Structural insight into modest binding of a non-PXXP ligand to the signal transducing adaptor molecule-2 Src homology 3 domain". The Journal of Biological Chemistry. 278 (48): 48162–8. doi:10.1074/jbc.M306677200. PMID 13129930.
  10. ^ Kato M, Miyazawa K, Kitamura N (December 2000). "A deubiquitinating enzyme UBPY interacts with the Src homology 3 domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKP". The Journal of Biological Chemistry. 275 (48): 37481–7. doi:10.1074/jbc.M007251200. PMID 10982817.

Further reading

  • D'Andrea A, Pellman D (1999). "Deubiquitinating enzymes: a new class of biological regulators". Critical Reviews in Biochemistry and Molecular Biology. 33 (5): 337–52. doi:10.1080/10409239891204251. PMID 9827704.
  • Nomura N, Nagase T, Miyajima N, Sazuka T, Tanaka A, Sato S, et al. (1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". DNA Research. 1 (5): 223–9. doi:10.1093/dnares/1.5.223. PMID 7584044.
  • Naviglio S, Mattecucci C, Matoskova B, Nagase T, Nomura N, Di Fiore PP, Draetta GF (June 1998). "UBPY: a growth-regulated human ubiquitin isopeptidase". The EMBO Journal. 17 (12): 3241–50. doi:10.1093/emboj/17.12.3241. PMC 1170662. PMID 9628861.
  • Kato M, Miyazawa K, Kitamura N (December 2000). "A deubiquitinating enzyme UBPY interacts with the Src homology 3 domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKP". The Journal of Biological Chemistry. 275 (48): 37481–7. doi:10.1074/jbc.M007251200. PMID 10982817.
  • Gnesutta N, Ceriani M, Innocenti M, Mauri I, Zippel R, Sturani E, et al. (October 2001). "Cloning and characterization of mouse UBPy, a deubiquitinating enzyme that interacts with the ras guanine nucleotide exchange factor CDC25(Mm)/Ras-GRF1". The Journal of Biological Chemistry. 276 (42): 39448–54. doi:10.1074/jbc.M103454200. hdl:2434/28853. PMID 11500497.
  • Kaneko T, Kumasaka T, Ganbe T, Sato T, Miyazawa K, Kitamura N, Tanaka N (November 2003). "Structural insight into modest binding of a non-PXXP ligand to the signal transducing adaptor molecule-2 Src homology 3 domain". The Journal of Biological Chemistry. 278 (48): 48162–8. doi:10.1074/jbc.M306677200. PMID 13129930.
  • Soares L, Seroogy C, Skrenta H, Anandasabapathy N, Lovelace P, Chung CD, et al. (January 2004). "Two isoforms of otubain 1 regulate T cell anergy via GRAIL". Nature Immunology. 5 (1): 45–54. doi:10.1038/ni1017. PMID 14661020. S2CID 27005972.
  • Wu X, Yen L, Irwin L, Sweeney C, Carraway KL (September 2004). "Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8". Molecular and Cellular Biology. 24 (17): 7748–57. doi:10.1128/MCB.24.17.7748-7757.2004. PMC 506982. PMID 15314180.
  • Berruti G, Martegani E (January 2005). "The deubiquitinating enzyme mUBPy interacts with the sperm-specific molecular chaperone MSJ-1: the relation with the proteasome, acrosome, and centrosome in mouse male germ cells". Biology of Reproduction. 72 (1): 14–21. doi:10.1095/biolreprod.104.030866. PMID 15342353.
  • Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H (June 2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Molecular & Cellular Proteomics. 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
  • Row PE, Prior IA, McCullough J, Clague MJ, Urbé S (May 2006). "The ubiquitin isopeptidase UBPY regulates endosomal ubiquitin dynamics and is essential for receptor down-regulation". The Journal of Biological Chemistry. 281 (18): 12618–24. doi:10.1074/jbc.M512615200. PMID 16520378.
  • Mizuno E, Kobayashi K, Yamamoto A, Kitamura N, Komada M (August 2006). "A deubiquitinating enzyme UBPY regulates the level of protein ubiquitination on endosomes". Traffic. 7 (8): 1017–31. doi:10.1111/j.1600-0854.2006.00452.x. PMID 16771824.
  • Avvakumov GV, Walker JR, Xue S, Finerty PJ, Mackenzie F, Newman EM, Dhe-Paganon S (December 2006). "Amino-terminal dimerization, NRDP1-rhodanese interaction, and inhibited catalytic domain conformation of the ubiquitin-specific protease 8 (USP8)". The Journal of Biological Chemistry. 281 (49): 38061–70. doi:10.1074/jbc.M606704200. PMID 17035239.
  • v
  • t
  • e
  • 1whb: Solution structure of the Rhodanese-like domain in human ubiquitin specific protease 8 (UBP8)
    1whb: Solution structure of the Rhodanese-like domain in human ubiquitin specific protease 8 (UBP8)
  • 2a9u: Structure of the N-terminal domain of Human Ubiquitin carboxyl-terminal hydrolase 8 (USP8)
    2a9u: Structure of the N-terminal domain of Human Ubiquitin carboxyl-terminal hydrolase 8 (USP8)
  • 2gfo: Structure of the Catalytic Domain of Human Ubiquitin Carboxyl-terminal Hydrolase 8
    2gfo: Structure of the Catalytic Domain of Human Ubiquitin Carboxyl-terminal Hydrolase 8
  • 2gwf: Structure of a USP8-NRDP1 complex
    2gwf: Structure of a USP8-NRDP1 complex
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