1-Amino-5-phosphonoindan-1-carboxylic acid
Chemical compound used in neuroscience research
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- 1-Amino-5-phosphonoindan-1-carboxylic acid
- 3881975
Y
- ChEMBL277961 Y
- Interactive image
- O=P(O)(O)c(c2)ccc1c2CCC1(N)C(O)=O
InChI
- InChI=1S/C10H12NO5P/c11-10(9(12)13)4-3-6-5-7(17(14,15)16)1-2-8(6)10/h1-2,5H,3-4,11H2,(H,12,13)(H2,14,15,16)Y
- Key:ZNQZXIHSJUDIKL-UHFFFAOYSA-NY
1-Amino-5-phosphonoindan-1-carboxylic acid (APICA) is a drug that is used in neuroscience research. It is a selective antagonist for the group II metabotropic glutamate receptors (mGluR2/3), and has been useful in the study of this receptor subfamily.[1][2][3][4][5]
References
- ^ Ma D, Tian H, Sun H, Kozikowski AP, Pshenichkin S, Wroblewski JT (May 1997). "Synthesis and biological activity of cyclic analogues of MPPG and MCPG as metabotropic glutamate receptor antagonists". Bioorganic & Medicinal Chemistry Letters. 7 (9): 1195–1198. doi:10.1016/S0960-894X(97)00177-7.
- ^ Ma D, Tian H, Zou G (January 1999). "Asymmetric Strecker-Type Reaction of alpha-Aryl Ketones. Synthesis of (S)-alphaM4CPG, (S)-MPPG, (S)-AIDA, and (S)-APICA, the Antagonists of Metabotropic Glutamate Receptors". The Journal of Organic Chemistry. 64 (1): 120–125. doi:10.1021/jo981297a. PMID 11674092.
- ^ Xi ZX, Baker DA, Shen H, Carson DS, Kalivas PW (January 2002). "Group II metabotropic glutamate receptors modulate extracellular glutamate in the nucleus accumbens". The Journal of Pharmacology and Experimental Therapeutics. 300 (1): 162–71. doi:10.1124/jpet.300.1.162. PMID 11752112.
- ^ Baker DA, Xi ZX, Shen H, Swanson CJ, Kalivas PW (October 2002). "The origin and neuronal function of in vivo nonsynaptic glutamate". The Journal of Neuroscience. 22 (20): 9134–41. doi:10.1523/JNEUROSCI.22-20-09134.2002. PMC 6757683. PMID 12388621.
- ^ Zhou F, Yao HH, Wu JY, Yang YJ, Ding JH, Zhang J, Hu G (August 2006). "Activation of Group II/III metabotropic glutamate receptors attenuates LPS-induced astroglial neurotoxicity via promoting glutamate uptake". Journal of Neuroscience Research. 84 (2): 268–77. doi:10.1002/jnr.20897. PMID 16752416. S2CID 44863411.
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Metabotropic glutamate receptor modulators
| mGluR1Tooltip Metabotropic glutamate receptor 1 |
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| mGluR5Tooltip Metabotropic glutamate receptor 5 |
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| mGluR2Tooltip Metabotropic glutamate receptor 2 |
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| mGluR3Tooltip Metabotropic glutamate receptor 3 |
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| mGluR4Tooltip Metabotropic glutamate receptor 4 |
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| mGluR6Tooltip Metabotropic glutamate receptor 6 |
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| mGluR7Tooltip Metabotropic glutamate receptor 7 | |
| mGluR8Tooltip Metabotropic glutamate receptor 8 |
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See also: Receptor/signaling modulators • Ionotropic glutamate receptor modulators • Glutamate metabolism/transport modulators
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