The 2010 Lexington, Kentucky mayoral election was held on November 2, 2010. The primary election was held on May 18, with the top two candidates advancing to the general election.
Incumbent mayor Jim Newberry, who was elected in 2006, was defeated for reelection by councilman Jim Gray. Mayoral elections in Lexington are nonpartisan; both Newberry and Gray were members of the Democratic Party.