Cl-4AS-1

Chemical compound
Cl-4AS-1
Clinical data
Other namesN-(2-Chlorophenyl)-3-oxo-4-aza-4-methylandrost-1-en-17α-carboxamide
Identifiers
  • (4aα,4bβ,6aα,7α,9aβ,9bα,11aβ)-N-(2-chlorophenyl)-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1,4,6a-trimethyl-2-oxo-1H-indeno[5,4-f]quinoline-7-carboxamide
CAS Number
  • 188589-66-4
PubChem CID
  • 9932961
ChemSpider
  • 26232143
Chemical and physical data
FormulaC26H33ClN2O2
Molar mass441.01 g·mol−1
3D model (JSmol)
  • Interactive image
  • C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2C(=O)NC4=CC=CC=C4Cl)CC[C@@H]5[C@@]3(C=CC(=O)N5C)C
InChI
  • InChI=1S/C26H33ClN2O2/c1-25-14-12-18-16(8-11-22-26(18,2)15-13-23(30)29(22)3)17(25)9-10-19(25)24(31)28-21-7-5-4-6-20(21)27/h4-7,13,15-19,22H,8-12,14H2,1-3H3,(H,28,31)/t16-,17-,18-,19+,22+,25-,26+/m0/s1
  • Key:CTVXDPDUOKQBKZ-GFNRTWGOSA-N

Cl-4AS-1 is a dual anabolic–androgenic steroid (AAS) and 5α-reductase inhibitor.[1][2] It is a potent and selective full agonist of the androgen receptor (IC50 = 12 nM) and inhibitor of 5α-reductase types I and II (IC50 = 6 and 10 nM, respectively).[1][2] Structurally, Cl-4AS-1 is a 4-azasteroid.[1]

See also

  • TFM-4AS-1

References

  1. ^ a b c Tolman RL, Sahoo SP, Bakshi RK, Gratale D, Patel G, Patel S, Toney J, Chang B, Harris GS (1997). "4-Methyl-3-oxo-4-aza-5alpha-androst-1-ene-17beta-N-aryl-carboxamides: an approach to combined androgen blockade [5alpha-reductase inhibition with androgen receptor binding in vitro]". J. Steroid Biochem. Mol. Biol. 60 (5–6): 303–9. doi:10.1016/s0960-0760(96)00199-9. PMID 9219921. S2CID 54405031.
  2. ^ a b Schmidt A, Harada S, Kimmel DB, Bai C, Chen F, Rutledge SJ, Vogel RL, Scafonas A, Gentile MA, Nantermet PV, McElwee-Witmer S, Pennypacker B, Masarachia P, Sahoo SP, Kim Y, Meissner RS, Hartman GD, Duggan ME, Rodan GA, Towler DA, Ray WJ (2009). "Identification of anabolic selective androgen receptor modulators with reduced activities in reproductive tissues and sebaceous glands". J. Biol. Chem. 284 (52): 36367–76. doi:10.1074/jbc.M109.049734. PMC 2794752. PMID 19846549.

External links

  • Cl-4AS-1 - Santa Cruz Biotechnology


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ARTooltip Androgen receptor
Agonists
SARMsTooltip Selective androgen receptor modulator
Antagonists
GPRC6A
Agonists
See also
Receptor/signaling modulators
Androgens and antiandrogens
Estrogen receptor modulators
Progesterone receptor modulators
List of androgens and anabolic steroids


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