Doravirine

Chemical compound
  • US DailyMed: Doravirine
Routes of
administrationBy mouth[1][2]ATC code
  • J05AG06 (WHO)
Legal statusLegal status
  • AU: S4 (Prescription only)
  • CA: ℞-only[3][4]
  • UK: POM (Prescription only)[5]
  • US: ℞-only[1]
  • EU: Rx-only[6]
Identifiers
  • 3-Chloro-5-({1-[(4-methyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl]-2-oxo-4-(trifluoromethyl)-1,2-dihydro-3-pyridinyl}oxy)benzonitrile
CAS Number
  • 1338225-97-0
PubChem CID
  • 58460047
DrugBank
  • DB12301
ChemSpider
  • 28424197
UNII
  • 913P6LK81M
KEGG
  • D10624
ChEMBL
  • ChEMBL2364608
PDB ligand
  • 2KW (PDBe, RCSB PDB)
CompTox Dashboard (EPA)
  • DTXSID30158386 Edit this at Wikidata
ECHA InfoCard100.234.454 Edit this at WikidataChemical and physical dataFormulaC17H11ClF3N5O3Molar mass425.75 g·mol−13D model (JSmol)
  • Interactive image
  • Cn1c(n[nH]c1=O)Cn2ccc(c(c2=O)Oc3cc(cc(c3)Cl)C#N)C(F)(F)F
  • InChI=1S/C17H11ClF3N5O3/c1-25-13(23-24-16(25)28)8-26-3-2-12(17(19,20)21)14(15(26)27)29-11-5-9(7-22)4-10(18)6-11/h2-6H,8H2,1H3,(H,24,28)
  • Key:ZIAOVIPSKUPPQW-UHFFFAOYSA-N

Doravirine, sold under the brand name Pifeltro, is a non-nucleoside reverse transcriptase inhibitor medication developed by Merck & Co. for use in the treatment of HIV/AIDS.

Doravirine was approved for medical use in the United States in August 2018.[7]

References

  1. ^ a b "Pifeltro- doravirine tablet, film coated". DailyMed. 10 October 2019. Retrieved 22 September 2020.
  2. ^ Collins S, Horn T. "The Antiretroviral Pipeline" (PDF). Pipeline Report. p. 10. Archived from the original (PDF) on 11 March 2016. Retrieved 6 December 2015.
  3. ^ "PRODUCT MONOGRAPH INCLUDING PATIENT MEDICATION INFORMATION : PIFELTRO" (PDF). Pdf.hres.ca. Retrieved 5 June 2022.
  4. ^ "Drug and medical device highlights 2018: Helping you maintain and improve your health". Health Canada. 14 October 2020. Retrieved 17 April 2024.
  5. ^ "Pifeltro 100 mg film-coated tablets - Summary of Product Characteristics (SmPC)". Medicines.org.uk. Retrieved 1 October 2020.
  6. ^ "Pifeltro EPAR". European Medicines Agency (EMA). Retrieved 1 October 2020.
  7. ^ "Drug Approval Package: Pifeltro (doravirine)". U.S. Food and Drug Administration (FDA). 9 October 2018. Retrieved 22 September 2020.
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Antiviral drugs: antiretroviral drugs used against HIV (primarily J05)
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°DHHS recommended initial regimen options. ◊Formerly or rarely used agent.
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