GPM6A

Protein-coding gene in the species Homo sapiens

GPM6A

Identifiers

Aliases

GPM6A, GPM6, M6A, glycoprotein M6A

External IDs

OMIM: 601275 MGI: 107671 HomoloGene: 3864 GeneCards: GPM6A

Gene location (Human)

Chr.	Chromosome 4 (human)^[1]

Band	4q34.2	Start	175,632,934 bp^[1]
Band	4q34.2	End	176,002,664 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 8 (mouse)^[2]

Band	8\|8 B1.3	Start	55,407,878 bp^[2]
Band	8\|8 B1.3	End	55,513,906 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

endothelial cell

Brodmann area 23

entorhinal cortex

superior frontal gyrus

orbitofrontal cortex

Region I of hippocampus proper

postcentral gyrus

middle temporal gyrus

ganglionic eminence

Brodmann area 46

Top expressed in

subiculum

piriform cortex

Region I of hippocampus proper

primary motor cortex

cingulate gyrus

cerebellar vermis

prefrontal cortex

olfactory tubercle

dorsomedial hypothalamic nucleus

barrel cortex

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	calcium channel activity protein binding
Cellular component	integral component of membrane extracellular vesicle cell projection membrane filopodium plasma membrane dendritic spine axonal growth cone axon neuronal cell body neuron projection extracellular exosome glutamatergic synapse integral component of presynaptic active zone membrane
Biological process	neuron projection morphogenesis neuron migration stem cell differentiation nervous system development calcium ion transmembrane transport synapse assembly positive regulation of filopodium assembly neural retina development response to bacterium neuron projection development regulation of synapse organization
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


2823


234267

Ensembl


ENSG00000150625


ENSMUSG00000031517

UniProt


P51674


P35802

RefSeq (mRNA)

NM_001261447 NM_001261448 NM_005277 NM_201591 NM_201592
NM_001388090 NM_001388091


NM_001253754 NM_001253756 NM_153581

RefSeq (protein)


NP_001248376 NP_001248377 NP_005268 NP_963885 NP_963886


NP_001240683 NP_001240685 NP_705809

Location (UCSC)

Chr 4: 175.63 – 176 Mb

Chr 8: 55.41 – 55.51 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Neuronal membrane glycoprotein M6-a is a protein that in humans is encoded by the GPM6A gene.^[5]^[6]^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000150625 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031517 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Olinsky S, Loop BT, DeKosky A, Ripepi B, Weng W, Cummins J, et al. (May 1996). "Chromosomal mapping of the human M6 genes". Genomics. 33 (3): 532–6. doi:10.1006/geno.1996.0231. PMID 8661015.
^ Liang YJ, Wu DF, Stumm R, Höllt V, Koch T (July 2008). "Membrane glycoprotein M6A promotes mu-opioid receptor endocytosis and facilitates receptor sorting into the recycling pathway". Cell Research. 18 (7): 768–79. doi:10.1038/cr.2008.71. PMID 18574501.
^ "Entrez Gene: GPM6A glycoprotein M6A".

Boks MP, Hoogendoorn M, Jungerius BJ, Bakker SC, Sommer IE, Sinke RJ, et al. (September 2008). "Do mood symptoms subdivide the schizophrenia phenotype? Association of the GMP6A gene with a depression subgroup". American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics. 147B (6): 707–11. doi:10.1002/ajmg.b.30667. PMID 18163405. S2CID 30736289.
DeGiorgis JA, Jaffe H, Moreira JE, Carlotti CG, Leite JP, Pant HC, Dosemeci A (2005). "Phosphoproteomic analysis of synaptosomes from human cerebral cortex". Journal of Proteome Research. 4 (2): 306–15. doi:10.1021/pr0498436. PMID 15822905.
Shin BK, Wang H, Yim AM, Le Naour F, Brichory F, Jang JH, et al. (February 2003). "Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function". The Journal of Biological Chemistry. 278 (9): 7607–16. doi:10.1074/jbc.M210455200. PMID 12493773.
Mukobata S, Hibino T, Sugiyama A, Urano Y, Inatomi A, Kanai Y, et al. (October 2002). "M6a acts as a nerve growth factor-gated Ca(2+) channel in neuronal differentiation". Biochemical and Biophysical Research Communications. 297 (4): 722–8. doi:10.1016/S0006-291X(02)02284-2. PMID 12359212.
Shimizu F, Watanabe TK, Fujiwara T, Takahashi E, Nakamura Y, Maekawa H (1996). "Isolation and mapping of the human glycoprotein M6 gene (GPM6A) to 4q33-->q34". Cytogenetics and Cell Genetics. 74 (1–2): 138–9. doi:10.1159/000134401. PMID 8893821.
Yan Y, Narayanan V, Lagenaur C (July 1996). "Expression of members of the proteolipid protein gene family in the developing murine central nervous system". The Journal of Comparative Neurology. 370 (4): 465–78. doi:10.1002/(SICI)1096-9861(19960708)370:4<465::AID-CNE4>3.0.CO;2-2. PMID 8807448. S2CID 27877672.