Neuronal calcium sensor

Neuronal Calcium Sensor is a large family of proteins which work as calcium dependent molecular switches and includes members like Frequenin (NCS1), recoverin, GCAP, neurocalcin, visinin etc.^[1] All the members carry 4 EF hand motifs (out of which only 2 or 3 bind calcium) and an N-myristoyl group.^[2]

Members of NCS family

Highly evolutionarily conserved ^[3]
NCS1 (Frequenin)^[4]
VILIP-1 (Visinin-like-protein-1)
HPCAL4 (Visinin-like-protein-2)
HPCAL1 (Visinin-like-protein-3)
hippocalcin
neurocalcin
recoverin
Guanylate cyclase activator proteins (GCAPs)
Potassium Channel interacting proteins (KChIPs 1–4), including:

KCNIP1, KCNIP2, Calsenilin or DREAM/KChIP-3/KCNIP3 (downstream regulatory element antagonist modulator/potassium channel interacting protein), KCNIP4

References

^ Burgoyne RD (2007). "Neuronal calcium sensor proteins: generating diversity in neuronal Ca2+ signalling". Nat. Rev. Neurosci. 8 (3): 182–193. doi:10.1038/nrn2093. PMC 1887812. PMID 17311005.
^ Burgoyne RD, O'Callaghan DW, Hasdemir B, Haynes LP, Tepikin AV (2004). "Neuronal Ca2+-sensor proteins: multitalented regulators of neuronal function". Trends Neurosci. 27 (4): 203–9. doi:10.1016/j.tins.2004.01.010. PMID 15046879. S2CID 24156457.
^ Weiss JL, Hui H, Burgoyne RD (2010). "Neuronal calcium sensor-1 regulation of calcium channels, secretion, and neuronal outgrowth". Cell. Mol. Neurobiol. 30 (8): 1283–92. doi:10.1007/s10571-010-9588-7. PMID 21104311. S2CID 2270302.
^ Tsvetkov, PO; Roman, AY; Baksheeva, VE; Nazipova, AA; Shevelyova, MP; Vladimirov, VI; Buyanova, MF; Zinchenko, DV; Zamyatnin AA, Jr; Devred, F; Golovin, AV; Permyakov, SE; Zernii, EY (2018). "Functional Status of Neuronal Calcium Sensor-1 Is Modulated by Zinc Binding". Frontiers in Molecular Neuroscience. 11: 459. doi:10.3389/fnmol.2018.00459. PMC 6302015. PMID 30618610.

External links

Neuronal+Calcium-Sensor+Proteins at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
NCS proteins

Cell signaling: calcium signaling and calcium metabolism

Cell membrane

Adhesion molecules	Cadherins CDH1 CDH2 CDH3 CDH4 CDH5 CDH6 CDH7 CDH8 CDH9 CDH10 CDH11 CDH12 CDH13 CDH14 CDH15 CDH16 CDH17
Calcium channels	Ligand-gated 5-HT3 receptor Ionotropic glutamate receptors AMPA receptors Kainate receptors NMDA receptors P2X receptors Voltage-gated L N P R T TRP channels TRPA TRPC TRPV
Calcium pumps	Sodium-calcium exchangers SLC3A2 SLC8A1
GPCRs	Calcium-sensing receptor
Annexins	A1 A2 A3 A4 A5 A6 A7 A8 A8-L2 A9 A10 A11 A12 A13

Intracellular signaling

Second messengers	IP3 NAADP cADPR
Intracellular channels	IP3 receptor Ryanodine receptor Calcium-induced calcium release
Intracellular pumps	SERCA ATP2A1 ATP2A2 ATP2A3 Sodium-calcium exchangers SLC8B1 SLC24A5
Sensors and chelators	Calbindin Calmodulin CALM1 CALM2 CALM3 CALML3 CALML5 Calsequestrin Calretinin Gelsolin Neuronal calcium sensors Calsenilin Frequenin GUCA 1A 1B Hippocalcin Neurocalcin Recoverin Visinin Pervalbumin Phospholamban Sarcalumenin Synaptotagmins SYT1 SYT2 SYT3 SYT4 SYT5 SYT6 SYT7 SYT9 SYT11 SYT13 SYT14 S100 S100P Troponin C TNNC1 TNNC2
Calcium-dependent chaperones	Calreticulin Calnexin HSPA5 HSP90B1
Calcium-dependent kinases	CaM kinases CAMK1 CAMK2 A B D G CAMK3 CAMK4 Protein kinase C
Calcium-dependent proteases	Calpains CAPN1 CAPN2 CAPN3 CAPN4 CAPN5 CAPN6 CAPN7 CAPN8 CAPN9 CAPN10
Indirect regulators	Calcitonin Parathyroid hormone Vitamin D Vitamin K

Extracellular chelators

Extracellular matrix proteins	Fibulins FBLN1 FBLN2 FBLN3 FBLN4 FBLN5 Hemicentin 1 Matrix gla protein Osteonectin SIBLINGs Bone sialoprotein Dentin matrix phosphoprotein Dentin sialophosphoprotein Osteopontin
Secreted hormones	Osteocalcin

Calcium-binding domains

v t e Protein: nerve tissue protein
Synuclein	Alpha-synuclein Beta-synuclein Gamma-synuclein
Other	Agrin Chimerin Granin Chromogranin A B FMR1 Gap-43 protein GLUT3 Myelin Brain natriuretic peptide Nerve growth factor SCG5 Neurogranin Neuronal calcium sensor Neuropeptide Olfactory marker protein S100 protein Calgranulin Synapsin 1 2 3 Synaptophysin Tubulin GPM6A