NCOA7

Protein-coding gene in the species Homo sapiens
NCOA7
Identifiers
AliasesNCOA7, ERAP140, ESNA1, NCOA7-AS, Nbla00052, Nbla10993, TLDC4, dJ187J11.3, nuclear receptor coactivator 7
External IDsOMIM: 609752 MGI: 2444847 HomoloGene: 65245 GeneCards: NCOA7
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for NCOA7
Genomic location for NCOA7
Band6q22.31-q22.32Start125,781,161 bp[1]
End125,932,034 bp[1]
Gene location (Mouse)
Chromosome 10 (mouse)
Chr.Chromosome 10 (mouse)[2]
Chromosome 10 (mouse)
Genomic location for NCOA7
Genomic location for NCOA7
Band10|10 A4Start30,504,995 bp[2]
End30,679,322 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • Brodmann area 23

  • pancreatic epithelial cell

  • Brodmann area 46

  • middle temporal gyrus

  • endothelial cell

  • parietal pleura

  • visceral pleura

  • spinal ganglia

  • pons

  • cerebellar vermis
Top expressed in
  • cervix

  • ventral tegmental area

  • dorsomedial hypothalamic nucleus

  • medial vestibular nucleus

  • subiculum

  • superior colliculus

  • blood

  • dorsal tegmental nucleus

  • paraventricular nucleus of hypothalamus

  • piriform cortex
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • protein binding
  • nuclear receptor coactivator activity
Cellular component
  • intracellular anatomical structure
  • nucleus
Biological process
  • regulation of transcription, DNA-templated
  • transcription, DNA-templated
  • positive regulation of transcription by RNA polymerase II
  • negative regulation of cellular response to oxidative stress
  • negative regulation of peptidyl-cysteine S-nitrosylation
  • negative regulation of oxidative stress-induced neuron death
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

135112

211329

Ensembl

ENSG00000111912

ENSMUSG00000039697

UniProt

Q8NI08

Q6DFV7

RefSeq (mRNA)
NM_001122842
NM_001199619
NM_001199620
NM_001199621
NM_001199622

NM_181782

NM_001111267
NM_172495
NM_001358841
NM_001358842

RefSeq (protein)
NP_001116314
NP_001186548
NP_001186549
NP_001186550
NP_001186551

NP_861447

NP_001104737
NP_766083
NP_001345770
NP_001345771

Location (UCSC)Chr 6: 125.78 – 125.93 MbChr 10: 30.5 – 30.68 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Nuclear receptor coactivator 7 is a protein that in humans is encoded by the NCOA7 gene.[5][6]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000111912 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039697 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Shao W, Halachmi S, Brown M (Apr 2002). "ERAP140, a Conserved Tissue-Specific Nuclear Receptor Coactivator". Mol Cell Biol. 22 (10): 3358–72. doi:10.1128/MCB.22.10.3358-3372.2002. PMC 133794. PMID 11971969.
  6. ^ "Entrez Gene: NCOA7 nuclear receptor coactivator 7".

External links

Further reading

  • Ohira M, Morohashi A, Nakamura Y, et al. (2003). "Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma". Cancer Lett. 197 (1–2): 63–8. doi:10.1016/S0304-3835(03)00085-5. PMID 12880961.
  • Halachmi S, Marden E, Martin G, et al. (1994). "Estrogen receptor-associated proteins: possible mediators of hormone-induced transcription". Science. 264 (5164): 1455–8. Bibcode:1994Sci...264.1455H. doi:10.1126/science.8197458. PMID 8197458.
  • Nguyen TA, Hoivik D, Lee JE, Safe S (1999). "Interactions of nuclear receptor coactivator/corepressor proteins with the aryl hydrocarbon receptor complex". Arch. Biochem. Biophys. 367 (2): 250–7. doi:10.1006/abbi.1999.1282. PMID 10395741.
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  • Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
  • Rushing SR, Denison MS (2002). "The silencing mediator of retinoic acid and thyroid hormone receptors can interact with the aryl hydrocarbon (Ah) receptor but fails to repress Ah receptor-dependent gene expression". Arch. Biochem. Biophys. 403 (2): 189–201. doi:10.1016/S0003-9861(02)00233-3. PMID 12139968.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
  • Durand M, Kolpak A, Farrell T, et al. (2007). "The OXR domain defines a conserved family of eukaryotic oxidation resistance proteins". BMC Cell Biol. 8: 13. doi:10.1186/1471-2121-8-13. PMC 1847813. PMID 17391516.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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Coactivators
Corepressors
ATP-dependent remodeling factors
  • Chromatin Structure Remodeling (RSC) Complex
  • SWI/SNF


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