Trolnitrate

Trolnitrate
Names
IUPAC name
2-[bis(2-nitrooxyethyl)amino]ethyl nitrate
Identifiers
CAS Number
  • 7077-34-1 ☒N
3D model (JSmol)
  • Interactive image
ChemSpider
  • 11015 checkY
ECHA InfoCard 100.027.615 Edit this at Wikidata
PubChem CID
  • 11499
UNII
  • B9M85U075P checkY
CompTox Dashboard (EPA)
  • DTXSID7023722 Edit this at Wikidata
InChI
  • InChI=1S/C6H12N4O9/c11-8(12)17-4-1-7(2-5-18-9(13)14)3-6-19-10(15)16/h1-6H2 checkY
    Key: HWKQNAWCHQMZHK-UHFFFAOYSA-N checkY
  • C(CO[N+](=O)[O-])N(CCO[N+](=O)[O-])CCO[N+](=O)[O-]
Properties
Chemical formula
C6H12N4O9
Molar mass 284.18 g/mol
Pharmacology
C01DA09 (WHO)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
☒N verify (what is checkY☒N ?)
Infobox references
Chemical compound

Trolnitrate is an organic nitrate with vasodilator activity that is used to prevent or ameliorate attacks of angina pectoris.[1] Trolnitrate dilates the coronary vessels because of its basic action as a smooth muscle depressant, just as do nitroglycerin and other organic nitrates.[2]

References

  1. ^ "Medical Definition of TROLNITRATE".
  2. ^ "NCATS Inxight Drugs — TROLNITRATE".


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Forms
  • Nitroxyl anion (NO; oxonitrate(1-), hyponitrite anion)
  • Nitric oxide (NO; nitrogen monoxide)
  • Nitrosonium (NO+; nitrosyl cation)
Targets
sGC
  • Inhibitors: ODQ
NO donors
(prodrugs)
  • NONOates (diazeniumdiolates): Diethylamine/NO (DEA/NO)
  • Diethylenetriamine/NO (DETA/NO)
  • GLO/NO
  • JS-K
  • Methylamine hexamethylene methylamine/NO (MAHMA/NO)
  • PROLI/NO
  • Spermine/NO (SPER/NO)
  • V-PYRRO/NO
  • Unsorted: Cimlanod
  • FK-409
  • FR144220
  • FR146881
  • N-Acetyl-N-acetoxy-4-chlorobenzenesulfonamide
Enzyme
(inhibitors)
NOS
nNOS
iNOS
  • 1-Amino-2-hydroxyguanidine
  • 2-Ethylaminoguanidine
  • 2-Iminopiperidine
  • 1400W
  • AEITU
  • Aminoguanidine (pimagedine)
  • AMT
  • AR-C 102222
  • BYK-191023
  • Canavanine
  • Cindunistat (SD-6010)
  • EITU
  • IPTU
  • MITU
  • N5-(1-Iminoethyl)-L-ornithine (L-NIO)
  • N6-(1-Iminoethyl)-L-lysine (L-NIL)
  • Nω-Methyl-L-arginine (L-NMA)
  • Ronopterin (VAS-203)
  • TRIM
eNOS
Unsorted
Arginase
CAMK
  • Calmidazolium
  • W-7
Others
  • Precursors: L-Arginine
  • Nω-Hydroxy-L-arginine (NOHA)
See also: Receptor/signaling modulators


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