Nipradilol

Nipradilol
Names
IUPAC name
[8-[2-hydroxy-3-(propan-2-ylamino)propoxy]-3,4-dihydro-2H-chromen-3-yl] nitrate
Identifiers
CAS Number
  • 81486-22-8 checkY
3D model (JSmol)
  • Interactive image
ChemSpider
  • 65005
PubChem CID
  • 72006
UNII
  • FVM336I71Y checkY
InChI
  • InChI=1S/C15H22N2O6/c1-10(2)16-7-12(18)8-21-14-5-3-4-11-6-13(23-17(19)20)9-22-15(11)14/h3-5,10,12-13,16,18H,6-9H2,1-2H3
    Key: OMCPLEZZPVJJIS-UHFFFAOYSA-N
  • CC(C)NCC(COC1=CC=CC2=C1OCC(C2)O[N+](=O)[O-])O
Properties
Chemical formula
 C15H22N2O6
Molar mass 326.349 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references
Chemical compound

Nipradilol is a beta blocker and nitric oxide donor.[1]

References

  1. ^ Inoue, K; Kei Noguchi, K; Masumoto, M; Wakakura, G (2011). "Effect of five years of treatment with nipradilol eye drops in patients with normal tension glaucoma". Clinical Ophthalmology. 5: 1211–6. doi:10.2147/OPTH.S23233. PMC 3180485. PMID 21966188.
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Adrenergic receptor modulators
α1
Agonists
Antagonists
α2
Agonists
Antagonists
β
Agonists
Antagonists
  • See also: Receptor/signaling modulators
  • Dopaminergics
  • Serotonergics
  • Monoamine reuptake inhibitors
  • Monoamine releasing agents
  • Monoamine metabolism modulators
  • Monoamine neurotoxins
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Forms
  • Nitroxyl anion (NO−; oxonitrate(1-), hyponitrite anion)
  • Nitric oxide (NO⋅; nitrogen monoxide)
  • Nitrosonium (NO+; nitrosyl cation)
Targets
sGC
  • Inhibitors: ODQ
NO donors
(prodrugs)
  • NONOates (diazeniumdiolates): Diethylamine/NO (DEA/NO)
  • Diethylenetriamine/NO (DETA/NO)
  • GLO/NO
  • JS-K
  • Methylamine hexamethylene methylamine/NO (MAHMA/NO)
  • PROLI/NO
  • Spermine/NO (SPER/NO)
  • V-PYRRO/NO
  • Unsorted: Cimlanod
  • FK-409
  • FR144220
  • FR146881
  • N-Acetyl-N-acetoxy-4-chlorobenzenesulfonamide
Enzyme
(inhibitors)
NOS
nNOS
iNOS
  • 1-Amino-2-hydroxyguanidine
  • 2-Ethylaminoguanidine
  • 2-Iminopiperidine
  • 1400W
  • AEITU
  • Aminoguanidine (pimagedine)
  • AMT
  • AR-C 102222
  • BYK-191023
  • Canavanine
  • Cindunistat (SD-6010)
  • EITU
  • IPTU
  • MITU
  • N5-(1-Iminoethyl)-L-ornithine (L-NIO)
  • N6-(1-Iminoethyl)-L-lysine (L-NIL)
  • Nω-Methyl-L-arginine (L-NMA)
  • Ronopterin (VAS-203)
  • TRIM
eNOS
Unsorted
Arginase
CAMK
  • Calmidazolium
  • W-7
Others
  • Precursors: L-Arginine
  • Nω-Hydroxy-L-arginine (NOHA)
See also: Receptor/signaling modulators


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