Ubiquitin carboxyl-terminal hydrolase L5

Protein-coding gene in the species Homo sapiens
UCHL5
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

3A7S, 3IHR, 3RII, 3RIS, 3TB3, 4UEL, 4UEM, 4UF5, 4UF6, 4WLP

Identifiers
AliasesUCHL5, CGI-70, INO80R, UCH-L5, UCH37, Ubiquitin carboxyl-terminal hydrolase L5, ubiquitin C-terminal hydrolase L5
External IDsOMIM: 610667; MGI: 1914848; HomoloGene: 9326; GeneCards: UCHL5; OMA:UCHL5 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for UCHL5
Genomic location for UCHL5
Band1q31.2Start193,012,250 bp[1]
End193,060,080 bp[1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[2]
Chromosome 1 (mouse)
Genomic location for UCHL5
Genomic location for UCHL5
Band1 F|1 62.54 cMStart143,653,010 bp[2]
End143,683,204 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • Achilles tendon

  • islet of Langerhans

  • body of pancreas

  • prefrontal cortex

  • muscle of thigh

  • rectum

  • monocyte

  • gonad

  • gastrocnemius muscle

  • epithelium of colon
Top expressed in
  • morula

  • embryo

  • blastocyst

  • yolk sac

  • parotid gland

  • otic placode

  • tail of embryo

  • medial vestibular nucleus

  • deep cerebellar nuclei

  • epiblast
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • cysteine-type peptidase activity
  • thiol-dependent deubiquitinase
  • peptidase activity
  • protein binding
  • endopeptidase inhibitor activity
  • hydrolase activity
  • RNA binding
  • proteasome binding
Cellular component
  • cytoplasm
  • intracellular anatomical structure
  • proteasome complex
  • nucleus
  • cytosolic proteasome complex
  • nucleoplasm
  • mitochondrion
  • cytosol
  • Ino80 complex
Biological process
  • regulation of proteasomal protein catabolic process
  • DNA recombination
  • regulation of transcription, DNA-templated
  • lateral ventricle development
  • ubiquitin-dependent protein catabolic process
  • transcription, DNA-templated
  • proteolysis
  • cellular response to DNA damage stimulus
  • forebrain morphogenesis
  • DNA repair
  • midbrain development
  • negative regulation of endopeptidase activity
  • protein deubiquitination
  • negative regulation of proteasomal ubiquitin-dependent protein catabolic process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

51377

56207

Ensembl

ENSG00000116750

ENSMUSG00000018189

UniProt

Q9Y5K5
Q5LJB0

Q9WUP7

RefSeq (mRNA)
NM_001199261
NM_001199262
NM_001199263
NM_015984
NM_001350840

NM_001350841
NM_001350842
NM_001350843
NM_001350844
NM_001350845
NM_001350846
NM_001350847
NM_001350848
NM_001350849
NM_001350850
NM_001350851
NM_001350852

NM_001159866
NM_019562

RefSeq (protein)
NP_001186190
NP_001186191
NP_001186192
NP_057068
NP_001337769

NP_001337770
NP_001337771
NP_001337772
NP_001337773
NP_001337774
NP_001337775
NP_001337776
NP_001337777
NP_001337778
NP_001337779
NP_001337780
NP_001337781

NP_001153338
NP_062508

Location (UCSC)Chr 1: 193.01 – 193.06 MbChr 1: 143.65 – 143.68 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ubiquitin carboxyl-terminal hydrolase isozyme L5 is an enzyme that in humans is encoded by the UCHL5 gene.[5][6][7]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000116750 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000018189 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (Aug 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
  6. ^ Wicks SJ, Haros K, Maillard M, Song L, Cohen RE, Dijke PT, Chantry A (Dec 2005). "The deubiquitinating enzyme UCH37 interacts with Smads and regulates TGF-beta signalling". Oncogene. 24 (54): 8080–4. doi:10.1038/sj.onc.1208944. PMID 16027725.
  7. ^ "Entrez Gene: UCHL5 ubiquitin carboxyl-terminal hydrolase L5".

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. Bibcode:2000PNAS...97.9543H. doi:10.1073/pnas.160270997. PMC 16901. PMID 10931946.
  • Li T, Duan W, Yang H, et al. (2001). "Identification of two proteins, S14 and UIP1, that interact with UCH37". FEBS Lett. 488 (3): 201–5. doi:10.1016/S0014-5793(00)02436-4. hdl:10536/DRO/DU:30009147. PMID 11163772. S2CID 40717095.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Rolén U, Kobzeva V, Gasparjan N, et al. (2006). "Activity profiling of deubiquitinating enzymes in cervical carcinoma biopsies and cell lines". Mol. Carcinog. 45 (4): 260–9. doi:10.1002/mc.20177. PMID 16402389. S2CID 6633207.
  • Gandhi TK, Zhong J, Mathivanan S, et al. (2006). "Analysis of the human protein interactome and comparison with yeast, worm and fly interaction datasets". Nat. Genet. 38 (3): 285–93. doi:10.1038/ng1747. PMID 16501559. S2CID 1446423.
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
  • Yao T, Song L, Xu W, et al. (2006). "Proteasome recruitment and activation of the Uch37 deubiquitinating enzyme by Adrm1". Nat. Cell Biol. 8 (9): 994–1002. doi:10.1038/ncb1460. PMID 16906146. S2CID 25308728.
  • Hamazaki J, Iemura S, Natsume T, et al. (2006). "A novel proteasome interacting protein recruits the deubiquitinating enzyme UCH37 to 26S proteasomes". EMBO J. 25 (19): 4524–36. doi:10.1038/sj.emboj.7601338. PMC 1589993. PMID 16990800.
  • Qiu XB, Ouyang SY, Li CJ, et al. (2007). "hRpn13/ADRM1/GP110 is a novel proteasome subunit that binds the deubiquitinating enzyme, UCH37". EMBO J. 25 (24): 5742–53. doi:10.1038/sj.emboj.7601450. PMC 1698896. PMID 17139257.


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