United Kingdom Model for End-Stage Liver Disease

The United Kingdom Model for End-Stage Liver Disease or UKELD is a medical scoring system used to predict the prognosis of patients with chronic liver disease. It is used in the United Kingdom to help determine the need for liver transplantation.^[1] It was developed from the MELD score, incorporating the serum sodium level.^[2]

Determination

The UKELD score is calculated from the patient's INR, serum creatinine, serum bilirubin and serum sodium, according to the formula:^[3]

$(5.395\times \ln INR)+(1.485\times \ln creatinine)+(3.13\times \ln bilirubin)-(81.565\times \ln Na)+435$

Interpretation

Higher UKELD scores equate to higher one-year mortality risk. A UKELD score of 49 indicates a 9% one-year risk of mortality, and is the minimum score required to be added to the liver transplant waiting list in the U.K.^[1] A UKELD score of 60 indicates a 50% chance of one-year survival.^[2]

History

The UKELD score was developed in 2008 to aid in the selection of patients for liver transplantation in the U.K.^[4]

References

^ ^a ^b "Liver Transplant - Who can use it - NHS Choices". NHS.uk. 2011-11-09. Retrieved 2013-01-20.
^ ^a ^b Asrani SK, Kim WR (May 2010). "Organ allocation for chronic liver disease: model for end-stage liver disease and beyond". Curr. Opin. Gastroenterol. 26 (3): 209–13. doi:10.1097/MOG.0b013e32833867d8. PMC 2919807. PMID 20224394.
^ Evangelos Cholongitas; Giacomo Germani; Andrew K. Burroughs (December 2010). "Prioritization for liver transplantation (Table 2)". Nature Reviews Gastroenterology & Hepatology. 7 (12). Nature Publishing Group: 659–668. doi:10.1038/nrgastro.2010.169. PMID 21045793. S2CID 6211258.
^ Neuberger J, Gimson A, Davies M, et al. (February 2008). "Selection of patients for liver transplantation and allocation of donated livers in the UK". Gut. 57 (2): 252–7. doi:10.1136/gut.2007.131730. PMID 17895356. S2CID 35531839.

External links

"UKELD calculator". NHS Blood and Transplant. Retrieved 2013-01-20. (Microsoft Excel file)

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