Neklasični eikozanoid

Neklasični eikozanoidi su biološki aktivni signalni molekuli formirani oksigenacijom masnih kiselina dugih dvadeset ugljenika koje nisu klasični eikozanoidi.

Terminologija

Eikozanoid je kolektivni[1] naziv za oksigenisane derivate tri različite esencijalne masne kiseline: eikozapentaenoinska kiselina (EPA), arahidonska kiselina (AA) i dihomo-gama-linolna kiselina (DGLA).

Sadašnja upotreba ograničava termini na leukotriene (LT) i tri tipa prostanoida–prostaglandina (PG) prostaciklina (PGI), i tromboksana (TX). Međutim, nekoliko drugih klasa se tehnički može smatrati eikozanoidima, uključujući hepoksiline, resolvine, isofurans, izoprostane, lipoksine, epilipoksine, epoksieikozatrienoinske kiseline (EET) i endokanabinoide. Leukotrieni i prostanoidi se ponekad nazivaju klasičnim eikozanoidima[2][3][4] u kontrastu sa novim, neklasičnim eikozanoidima.[5][6][7][8]

Reference

  1. ↑ Funk, Colin D. (30 November 2001). „Prostaglandins and Leukotrienes: Advances in Eicosanoid Biology”. Science 294 (5548): 1871–1875. DOI:10.1126/science.294.5548.1871. PMID 11729303. Pristupljeno 2007-01-08. 
  2. ↑ Van Dyke TE, Serhan CN (2003). „Resolution of inflammation: a new paradigm for the pathogenesis of periodontal diseases”. J. Dent. Res. 82 (2): 82–90. DOI:10.1177/154405910308200202. PMID 12562878. 
  3. ↑ Serhan CN, Gotlinger K, Hong S, Arita M (2004). „Resolvins, docosatrienes, and neuroprotectins, novel omega-3-derived mediators, and their aspirin-triggered endogenous epimers: an overview of their protective roles in catabasis”. Prostaglandins Other Lipid Mediat. 73 (3–4): 155–72. DOI:10.1016/j.prostaglandins.2004.03.005. PMID 15290791. 
  4. ↑ Anderle P, Farmer P, Berger A, Roberts MA (2004). „Nutrigenomic approach to understanding the mechanisms by which dietary long-chain fatty acids induce gene signals and control mechanisms involved in carcinogenesis”. Nutrition (Burbank, Los Angeles County, Calif.) 20 (1): 103–8. DOI:10.1016/j.nut.2003.09.018. PMID 14698023. 
  5. ↑ Evans AR, Junger H, Southall MD i dr.. (2000). „Isoprostanes, novel eicosanoids that produce nociception and sensitize rat sensory neurons”. J. Pharmacol. Exp. Ther. 293 (3): 912–20. PMID 10869392. 
  6. ↑ O'Brien WF, Krammer J, O'Leary TD, Mastrogiannis DS (1993). „The effect of acetaminophen on prostacyclin production in pregnant women”. Am. J. Obstet. Gynecol. 168 (4): 1164–9. PMID 8475962. 
  7. ↑ Behrendt H, Kasche A, Ebner von Eschenbach C, Risse U, Huss-Marp J, Ring J (2001). „Secretion of proinflammatory eicosanoid-like substances precedes allergen release from pollen grains in the initiation of allergic sensitization”. Int. Arch. Allergy Immunol. 124 (1–3): 121–5. DOI:10.1159/000053688. PMID 11306946. 
  8. ↑ Sarau HM, Foley JJ, Schmidt DB i dr.. (1999). „In vitro and in vivo pharmacological characterization of SB 201993, an eicosanoid-like LTB4 receptor antagonist with anti-inflammatory activity”. Prostaglandins Leukot. Essent. Fatty Acids 61 (1): 55–64. DOI:10.1054/plef.1999.0074. PMID 10477044. 

Vidi još

  • Dokozanoidi
  • p
  • r
  • u
PrekursorProstanoidi
Prekursor
H2
Aktivni
D/J
D2
E/F
E2 (Dinoproston): Enprostil • Sulproston

E1 (Alprostadil): Mizoprostol • Gemeprost

F2α (Dinoprost): Bimatoprost • Karboprost • Latanoprost • Tafluprost • Travoprost • Unoproston
I
I2 (Prostaciklin/Epoprostenol): Beraprost • Iloprost • Treprostinil
A2 • B2
Leukotrieni (LT)
Prekursor
Inicijalni
A4 • B4
C4 • D4 • E4
Neklasični
Lipoksini (A4, B4) • Virodhamin
Po funkciji
bronhokonstrikcija (PGF2α, TXA2, LTC4, LTD4, LTE4)

vazokonstrikcija (PGF2α, TXA2, TXB2) • vazodilatacija (PGE2, PGI2, LTC4, LTD4, LTE4)

trombociti: indukuje (TXA2) inhibira (PGD2, PGI2) • leukociti: indukuje (TXA2, LTB4) inhibira (PGD2, PGE2)

Porođaj stimulacija: (PGE2 (Dinoproston), PGF2α (Dinoprost))

M: MET

mt, k, c/g/r/p/y/i, f/h/s/l/o/e, a/u, n, m

k, cgrp/y/i, f/h/s/l/o/e, au, n, m, epon

m (A16/C10), i (k, c/g/r/p/y/i, f/h/s/o/e, a/u, n, m)

Biohemijske familije: Ugljeni hidrati (Glikozidi,Alkoholi) • Lipidi (Steroidi,Fosfolipidi,Glikolipidi,Masne kiseline,Tetrapiroli) • Proteini (Aminokiseline,Peptidi,Glikoproteini) • Nukleobaze/Nukleinske kiseline