BD-1063
 | |
| IUPAC ime | |
|---|---|
1-[2-(3,4-dichlorophenyl)ethyl]-4-methylpiperazine | |
| Identifikatori | |
| CAS broj | 150208-28-9  Y |
| ATC kod | none |
| PubChem | CID 574780 |
| Hemijski podaci | |
| Formula | C13H18Cl2N2 |
| Molarna masa | 273.201 g/mol |
SMILES
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BD-1063 je antagonist sigma receptora koji je selektivan za σ1 tip. On blokira MDMA efekte u studijama na životinjama,[1] i umanjuje unos alkohola u modelima alkoholizma.[2]
Reference
- ^ Brammer MK, Gilmore DL, Matsumoto RR (2006). „Interactions between 3,4-methylenedioxymethamphetamine and sigma1 receptors”. European Journal of Pharmacology. 553 (1-3): 141—5. PMC 1780037
. PMID 17070798. doi:10.1016/j.ejphar.2006.09.038. - ^ Sabino V, Cottone P, Zhao Y, Iyer MR, Steardo L, Steardo L, Rice KC, Conti B, Koob GF, Zorrilla EP (2009). „The sigma-receptor antagonist BD-1063 decreases ethanol intake and reinforcement in animal models of excessive drinking”. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 34 (6): 1482—93. PMC 2669694 . PMID 18946467. doi:10.1038/npp.2008.192.
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Modulatori sigma receptora
- Agonisti: 3-PPP
- 4-PPBP
- 5-MeO-DMT
- Alazocin (SKF-10047)
- Amantadin
- ANAVEX2-73
- Arketamin
- BD-737
- BD-1052
- Kaptodiam
- Citalopram
- CGRP
- Kloperastin
- Kokain
- Kutamezin (SA-4503)
- Ciklazocin
- Dehidroepiandrosteron (DHEA) (prasteron)
- Dehidroepiandrosteron sulfat (DHEA-S) (prasteron sulfat)
- Dekstralorfan
- Dekstrometorfan (DXM)
- Dekstrorfan (DXO)
- Dimemorfan
- Dimetiltriptamin (DMT)
- Ditolilgvanidin (DTG)
- Donepezil
- Eliprodil
- Escitalopram
- Fabomotizol (afobazol)
- Fluoksetin
- Fluvoksamin
- Ifenprodil
- Igmesin (JO-1784)
- IPAB
- Ketamin
- L-687384
- MDMA (midomafetamin)
- Memantin
- Metamfetamin
- Metoksetamin
- Metilfenidat
- Nepinalon
- Neuropeptid Y
- Noskapin
- OPC-14523
- Opipramol
- Pentazocin
- Pentoksiverin (karbetapentan)
- PRE-084
- Pregnenolon
- Pregnenolon sulfat
- Pridopidin
- Racemetorfan (metorfan)
- Racemorfan (morfanol)
- UMB-23
- UMB-82
- Antagonisti: 3-PPP
- AC-927
- BD-1008
- BD-1031
- BD-1047
- BD-1060
- BD-1063
- BD-1067
- BMY-14802 (BMS-181100)
- CM-156
- Dup-734
- E-5842
- E-52862 (S1RA)
- Haloperidol
- LR-132
- LR-172
- MS-377
- NE-100
- NPC-16377
- Panamesin (EMD-57455)
- PD-144418
- Pentazocin
- Progesteron
- Rimkazol (BW-234U)
- Sertralin
- SR-31742A
- Alosterni modulatori: Fenitoin; Pozitivni: Metilfenilpiracetam
- SOMCL-668
- Nepoznati/nerazvrstani: 3-Metoksidekstralorfan
- 3-MeO-PCP
- 4C-T-2
- 4-IBP
- 4-IPBS
- 4-MeO-PCP
- 5-MeO-DALT
- 5-MeO-DiPT
- Amitriptilin
- Azidopamil
- Hlorpromazin
- Klemastin
- Klomipramin
- Klorgilin
- D-Deprenil
- DiPT
- DPT
- Ibogain
- Imipramin
- KCR-12-83.1
- Nemonaprid
- Noribogain
- RHL-033
- RS-67,333
- RTI-55
- Šafran
- Safinamid
- Selegilin
- Spipetijan
- Trifluoperazin
- W-18
- YKP10A
- Agonisti: 3-PPP
- Arketamin
- BD-1047
- BD1063
- Ditolilgvanidin (DTG)
- DKR-1005
- DKR-1051
- Haloperidol
- Ifenprodil
- Ketamin
- MDMA (midomafetamin)
- Metamfetamin
- OPC-14523
- Opipramol
- PB-28
- Fenciklidin
- Siramesin (Lu 28-179)
- UKH-1114
- Antagonisti: AC-927
- BD-1008
- BD-1067
- CM-156
- CT-1812
- LR-172
- MIN-101
- Panamesin (EMD-57455)
- SAS-0132
- Nepoznati/nerazvrstani: 3-Metoksidekstralorfan
- 3-MeO-PCE
- 4-MeO-PCP
- 5-MeO-DALT
- 5-MeO-DiPT
- Klemastin
- DiPT
- DPT
- Ibogain
- Nemonaprid
- Nepinalon
- Noribogain
- Pentazocin
- RS-67,333
- Safinamid
- TMA
- UMB-23
- UMB-82
- W-18
vrstani
- Agonisti: Berberin
- Etilketazocin
- Forfit
- Metafit
- Nalbufin
- Naluzotan
- Tapentadol
- Tenociklidin
- Antagonisti: AHD1
- AZ66
- Lamotrigin
- Nalokson
- SM-21
- UMB-100
- UMB-101
- UMB-103
- UMB-116
- YZ-011
- YZ-069
- YZ-185
- Alosterni modulatori: SKF-83959
- Nepoznati/nerazvrstani: 18-Metoksikoronaridin
- BMY-13980
- Butaklamol
- Karamifen
- Karvotrolin
- Hlorfenamin (hlorfeniramin)
- Hlorpromazin
- Cinarizin
- Cinuperon
- Klocapramin
- Dezocin
- EMD-59983
- Hipericin (kantarion)
- Flufenazin
- Gevotrolin (WY-47384)
- Mepiramin (pirilamin)
- Molindon
- Perfenazin
- Pimozid
- Proadifen
- Prometazin
- Propranolol
- Hinidin
- Remoksiprid
- SL 82.0715
- SR-31747A
- Tiospiron (BMY-13859)
- Venlafaksin
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