Collagen, type XVI, alpha 1

Protein found in humans
COL16A1
Identifiers
AliasesCOL16A1, 447AA, FP1572, collagen type XVI alpha 1, collagen type XVI alpha 1 chain
External IDsOMIM: 120326 MGI: 1095396 HomoloGene: 1397 GeneCards: COL16A1
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for COL16A1
Genomic location for COL16A1
Band1p35.2Start31,652,263 bp[1]
End31,704,319 bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for COL16A1
Genomic location for COL16A1
Band4|4 D2.2Start129,941,633 bp[2]
End129,993,076 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • tibia

  • canal of the cervix

  • sural nerve

  • right coronary artery

  • periodontal fiber

  • gastric mucosa

  • ascending aorta

  • middle frontal gyrus

  • right lobe of thyroid gland

  • left lobe of thyroid gland
Top expressed in
  • body of femur

  • belly cord

  • calvaria

  • vas deferens

  • seminiferous tubule

  • uterus

  • lip

  • spermatocyte

  • dermis

  • fossa
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • integrin binding
  • protein binding
  • extracellular matrix structural constituent
  • extracellular matrix structural constituent conferring tensile strength
Cellular component
  • extracellular region
  • collagen type XVI trimer
  • collagen
  • endoplasmic reticulum lumen
  • extracellular matrix
  • extracellular space
  • collagen-containing extracellular matrix
Biological process
  • cellular response to amino acid stimulus
  • integrin-mediated signaling pathway
  • female pregnancy
  • positive regulation of focal adhesion assembly
  • integrin activation
  • cell adhesion
  • extracellular matrix organization
  • cell adhesion mediated by integrin
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

1307

107581

Ensembl

ENSG00000084636

ENSMUSG00000040690

UniProt

Q07092

Q8BLX7

RefSeq (mRNA)

NM_001856

NM_028266

RefSeq (protein)

NP_001847

NP_082542
NP_001391281
NP_001391282

Location (UCSC)Chr 1: 31.65 – 31.7 MbChr 4: 129.94 – 129.99 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Collagen alpha-1(XVI) chain is a protein that in humans is encoded by the COL16A1 gene.[5][6]

Function

This gene encodes the alpha chain of type XVI collagen, a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Members of this collagen family are found in association with fibril-forming collagens such as type I and II, and serve to maintain the integrity of the extracellular matrix. High levels of type XVI collagen have been found in fibroblasts and keratinocytes, and in smooth muscle and amnion.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000084636 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040690 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Pan TC, Zhang RZ, Mattei MG, Timpl R, Chu ML (Aug 1992). "Cloning and chromosomal location of human alpha 1(XVI) collagen". Proc Natl Acad Sci U S A. 89 (14): 6565–9. Bibcode:1992PNAS...89.6565P. doi:10.1073/pnas.89.14.6565. PMC 49542. PMID 1631157.
  6. ^ a b "Entrez Gene: COL16A1 collagen, type XVI, alpha 1".

Further reading

  • Yamaguchi N, Kimura S, McBride OW, Hori H, Yamada Y, Kanamori T, Yamakoshi H, Nagai Y (1993). "Molecular cloning and partial characterization of a novel collagen chain, alpha 1(XVI), consisting of repetitive collagenous domains and cysteine-containing non-collagenous segments". J. Biochem. 112 (6): 856–63. doi:10.1093/oxfordjournals.jbchem.a123989. PMID 1284248.
  • Ratzinger S, Grässel S, Dowejko A, Reichert TE, Bauer RJ (2011). "Induction of type XVI collagen expression facilitates proliferation of oral cancer cells". Matrix Biology. 30 (2): 118–25. doi:10.1016/j.matbio.2011.01.001. PMID 21251976.
  • Sires UI, Dublet B, Aubert-Foucher E, van der Rest M, Welgus HG (1995). "Degradation of the COL1 domain of type XIV collagen by 92-kDa gelatinase". J. Biol. Chem. 270 (3): 1062–7. doi:10.1074/jbc.270.3.1062. PMID 7836360.
  • Tillet E, Mann K, Nischt R, Pan TC, Chu ML, Timpl R (1995). "Recombinant analysis of human alpha 1 (XVI) collagen. Evidence for processing of the N-terminal globular domain". Eur. J. Biochem. 228 (1): 160–8. doi:10.1111/j.1432-1033.1995.tb20245.x. PMID 7882999.
  • Grässel S, Timpl R, Tan EM, Chu ML (1997). "Biosynthesis and processing of type XVI collagen in human fibroblasts and smooth muscle cells". Eur. J. Biochem. 242 (3): 576–84. doi:10.1111/j.1432-1033.1996.0576r.x. PMID 9022684.
  • Ratzinger S, Grässel S, Dowejko A, Reichert TE, Bauer RJ (March 2011). "Induction of type XVI collagen expression facilitates proliferation of oral cancer cells". Matrix Biology. 30 (2): 118–25. doi:10.1016/j.matbio.2011.01.001. PMID 21251976.
  • Kassner A, Hansen U, Miosge N, Reinhardt DP, Aigner T, Bruckner-Tuderman L, Bruckner P, Grässel S (2004). "Discrete integration of collagen XVI into tissue-specific collagen fibrils or beaded microfibrils". Matrix Biol. 22 (2): 131–43. doi:10.1016/S0945-053X(03)00008-8. PMID 12782140.
  • Kassner A, Tiedemann K, Notbohm H, Ludwig T, Mörgelin M, Reinhardt DP, Chu ML, Bruckner P, Grässel S (2004). "Molecular structure and interaction of recombinant human type XVI collagen". J. Mol. Biol. 339 (4): 835–53. doi:10.1016/j.jmb.2004.03.042. PMID 15165854.
  • Eble JA, Kassner A, Niland S, Mörgelin M, Grifka J, Grässel S (2006). "Collagen XVI harbors an integrin alpha1 beta1 recognition site in its C-terminal domains". J. Biol. Chem. 281 (35): 25745–56. doi:10.1074/jbc.M509942200. PMID 16754661.

External links

  • "COL16A1 (collagen, type XVI, alpha 1)".
  • v
  • t
  • e
Extracellular
matrix
Collagen
Fibril forming
Other
Enzymes
Laminin
Other
Other


Stub icon

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

  • v
  • t
  • e