Collagen, type XXV, alpha 1

Protein found in humans
COL25A1
Identifiers
AliasesCOL25A1, AMY, CLAC, CLAC-P, CLACP, CFEOM5, Collagen, type XXV, alpha 1, collagen type XXV alpha 1, collagen type XXV alpha 1 chain
External IDsOMIM: 610004 MGI: 1924268 HomoloGene: 57111 GeneCards: COL25A1
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for COL25A1
Genomic location for COL25A1
Band4q25Start108,808,725 bp[1]
End109,302,752 bp[1]
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)[2]
Chromosome 3 (mouse)
Genomic location for COL25A1
Genomic location for COL25A1
Band3|3 G3Start129,925,150 bp[2]
End130,393,526 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • sperm

  • jejunal mucosa

  • Achilles tendon

  • subcutaneous adipose tissue

  • anterior pituitary

  • sural nerve

  • left lobe of thyroid gland

  • right lobe of thyroid gland

  • gallbladder

  • hypothalamus
Top expressed in
  • median eminence

  • medial dorsal nucleus

  • arcuate nucleus

  • substantia nigra

  • habenula

  • superior colliculus

  • lateral geniculate nucleus

  • lateral hypothalamus

  • ventromedial nucleus

  • ventral tegmental area
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • heparin binding
  • amyloid-beta binding
  • extracellular matrix structural constituent
  • extracellular matrix structural constituent conferring tensile strength
Cellular component
  • integral component of membrane
  • extracellular region
  • plasma membrane
  • collagen
  • endoplasmic reticulum lumen
  • membrane
  • extracellular space
  • integral component of plasma membrane
  • extracellular matrix
  • collagen-containing extracellular matrix
Biological process
  • axonogenesis involved in innervation
  • extracellular matrix organization
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

84570

77018

Ensembl

ENSG00000188517

ENSMUSG00000058897

UniProt

Q9BXS0

Q99MQ5

RefSeq (mRNA)

NM_001256074
NM_032518
NM_198721

NM_001244952
NM_029838
NM_198711

RefSeq (protein)

NP_001243003
NP_115907
NP_942014

NP_001231881
NP_084114
NP_942004

Location (UCSC)Chr 4: 108.81 – 109.3 MbChr 3: 129.93 – 130.39 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Collagen alpha-1(XXV) chain is a protein that in humans is encoded by the COL25A1 gene.[5][6]

COL25A1 is a brain-specific membrane-bound collagen. Proteolytic processing releases CLAC, a soluble form of COL25A1 containing the extracellular collagen domains that associates with senile plaques in Alzheimer disease (AD; MIM 104300) brains (Osada et al., 2005).[supplied by OMIM][6]

Interactions

Collagen, type XXV, alpha 1 has been shown to interact with Amyloid precursor protein.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000188517 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000058897 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Hashimoto T, Wakabayashi T, Watanabe A, Kowa H, Hosoda R, Nakamura A, Kanazawa I, Arai T, Takio K, Mann DM, Iwatsubo T (Apr 2002). "CLAC: a novel Alzheimer amyloid plaque component derived from a transmembrane precursor, CLAC-P/collagen type XXV". EMBO J. 21 (7): 1524–34. doi:10.1093/emboj/21.7.1524. PMC 125364. PMID 11927537.
  6. ^ a b "Entrez Gene: COL25A1 collagen, type XXV, alpha 1".

Further reading

  • Kakuyama H, Söderberg L, Horigome K, et al. (2006). "CLAC binds to aggregated Abeta and Abeta fragments, and attenuates fibril elongation". Biochemistry. 44 (47): 15602–9. doi:10.1021/bi051263e. PMID 16300410.
  • Söderberg L, Dahlqvist C, Kakuyama H, et al. (2005). "Collagenous Alzheimer amyloid plaque component assembles amyloid fibrils into protease resistant aggregates". FEBS J. 272 (9): 2231–6. doi:10.1111/j.1742-4658.2005.04647.x. hdl:10616/39314. PMID 15853808. S2CID 26505595.
  • Osada Y, Hashimoto T, Nishimura A, et al. (2005). "CLAC binds to amyloid beta peptides through the positively charged amino acid cluster within the collagenous domain 1 and inhibits formation of amyloid fibrils". J. Biol. Chem. 280 (9): 8596–605. doi:10.1074/jbc.M413340200. PMID 15615705.
  • Söderberg L, Kakuyama H, Möller A, et al. (2005). "Characterization of the Alzheimer's disease-associated CLAC protein and identification of an amyloid beta-peptide-binding site". J. Biol. Chem. 280 (2): 1007–15. doi:10.1074/jbc.M403628200. PMID 15522881.
  • Kowa H, Sakakura T, Matsuura Y, et al. (2004). "Mostly separate distributions of CLAC- versus Abeta40- or thioflavin S-reactivities in senile plaques reveal two distinct subpopulations of beta-amyloid deposits". Am. J. Pathol. 165 (1): 273–81. doi:10.1016/s0002-9440(10)63295-6. PMC 1618534. PMID 15215182.
  • Söderberg L, Zhukareva V, Bogdanovic N, et al. (2004). "Molecular identification of AMY, an Alzheimer disease amyloid-associated protein". J. Neuropathol. Exp. Neurol. 62 (11): 1108–17. doi:10.1093/jnen/62.11.1108. PMID 14656069.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
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Extracellular
matrix
Collagen
Fibril forming
Other
Enzymes
Laminin
Other
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