IRGM

Protein-coding gene in the species Homo sapiens

IRGM

Identifiers

Aliases

IRGM, IFI1, IRGM1, LRG-47, LRG47, immunity-related GTPase M, immunity related GTPase M

External IDs

OMIM: 608212 MGI: 1926262 HomoloGene: 78363 GeneCards: IRGM

Gene location (Human)

Chr.	Chromosome 5 (human)^[1]

Band	5q33.1	Start	150,846,521 bp^[1]
Band	5q33.1	End	150,900,736 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 11 (mouse)^[2]

Band	11\|11 B1.3	Start	58,090,444 bp^[2]
Band	11\|11 B1.3	End	58,113,608 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

Achilles tendon

appendix

lymph node

stromal cell of endometrium

blood

smooth muscle tissue

gallbladder

spleen

gastric mucosa

bone marrow

Top expressed in

mucous cell of stomach

Paneth cell

left lobe of liver

spleen

iris

subcutaneous adipose tissue

ciliary body

blood

jejunum

right lung lobe

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	nucleotide binding GTP binding hydrolase activity protein binding protein kinase binding protein serine/threonine kinase activator activity CARD domain binding BH3 domain binding GTPase activity
Cellular component	phagocytic vesicle membrane autophagosome membrane cell projection phagocytic cup plasma membrane membrane cytoplasmic vesicle Golgi membrane mitochondrion Golgi apparatus cytosol endoplasmic reticulum membrane
Biological process	autophagy inflammatory response immune system process autophagosome assembly positive regulation of protein phosphorylation positive regulation of autophagy positive regulation of peptidyl-threonine phosphorylation protein destabilization positive regulation of peptidyl-serine phosphorylation regulation of protein-containing complex assembly innate immune response protein stabilization defense response to Gram-negative bacterium positive regulation of interferon-gamma-mediated signaling pathway regulation of protein complex stability protein lipidation involved in autophagosome assembly CAMKK-AMPK signaling cascade nucleotide-binding oligomerization domain containing 2 signaling pathway cellular response to lipopolysaccharide positive regulation of autophagosome maturation positive regulation of protein serine/threonine kinase activity defense response cellular response to interferon-beta
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


345611


54396

Ensembl


ENSG00000237693


ENSMUSG00000069874

UniProt


A1A4Y4


Q9Z1M2

RefSeq (mRNA)


NM_001145805 NM_001346557


NM_019440

RefSeq (protein)


NP_001139277 NP_001333486


n/a

Location (UCSC)

Chr 5: 150.85 – 150.9 Mb

Chr 11: 58.09 – 58.11 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Immunity-related GTPase family M protein (IRGM), also known as interferon-inducible protein 1 (IFI1), is an enzyme that in humans is encoded by the IRGM gene.^[5]

IRGM is a member of the interferon-inducible GTPase family. The encoded protein may play a role in the innate immune response by regulating autophagy formation in response to intracellular pathogens.

The gene has been disabled by an Alu element for at least 25 million years in the primate lineage leading to great apes including humans, but it was re-enabled by an endogenous retrovirus called ERV-9.^[6]

Clinical relevance

Polymorphisms that affect the normal expression of this gene are associated with a susceptibility to Crohn's disease and tuberculosis.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000237693 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000069874 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: immunity-related GTPase family".
^ Bekpen C, Marques-Bonet T, Alkan C, Antonacci F, Leogrande MB, Ventura M, et al. (March 2009). "Death and resurrection of the human IRGM gene". PLOS Genetics. 5 (3): e1000403. doi:10.1371/journal.pgen.1000403. PMC 2644816. PMID 19266026.
^ Prescott NJ, Dominy KM, Kubo M, Lewis CM, Fisher SA, Redon R, et al. (May 2010). "Independent and population-specific association of risk variants at the IRGM locus with Crohn's disease" (PDF). Human Molecular Genetics. 19 (9): 1828–39. doi:10.1093/hmg/ddq041. PMC 2850616. PMID 20106866.

Laukens D, Georges M, Libioulle C, Sandor C, Mni M, Vander Cruyssen B, et al. (November 2010). "Evidence for significant overlap between common risk variants for Crohn's disease and ankylosing spondylitis". PLOS ONE. 5 (11): e13795. Bibcode:2010PLoSO...513795L. doi:10.1371/journal.pone.0013795. PMC 2970560. PMID 21072187.
Henckaerts L, Van Steen K, Verstreken I, Cleynen I, Franke A, Schreiber S, et al. (September 2009). "Genetic risk profiling and prediction of disease course in Crohn's disease patients". Clinical Gastroenterology and Hepatology. 7 (9): 972–980.e2. doi:10.1016/j.cgh.2009.05.001. PMID 19422935.
Palomino-Morales RJ, Oliver J, Gómez-García M, López-Nevot MA, Rodrigo L, Nieto A, et al. (June 2009). "Association of ATG16L1 and IRGM genes polymorphisms with inflammatory bowel disease: a meta-analysis approach". Genes and Immunity. 10 (4): 356–64. doi:10.1038/gene.2009.25. PMID 19491842. S2CID 36765281.
Intemann CD, Thye T, Niemann S, Browne EN, Amanua Chinbuah M, Enimil A, et al. (September 2009). "Autophagy gene variant IRGM -261T contributes to protection from tuberculosis caused by Mycobacterium tuberculosis but not by M. africanum strains". PLOS Pathogens. 5 (9): e1000577. doi:10.1371/journal.ppat.1000577. PMC 2735778. PMID 19750224.
Che N, Li S, Gao T, Zhang Z, Han Y, Zhang X, et al. (November 2010). "Identification of a novel IRGM promoter single nucleotide polymorphism associated with tuberculosis". Clinica Chimica Acta; International Journal of Clinical Chemistry. 411 (21–22): 1645–9. doi:10.1016/j.cca.2010.06.009. PMID 20547146.
Dema B, Fernández-Arquero M, Maluenda C, Polanco I, Figueredo MA, de la Concha EG, et al. (November 2009). "Lack of association of NKX2-3, IRGM, and ATG16L1 inflammatory bowel disease susceptibility variants with celiac disease". Human Immunology. 70 (11): 946–9. doi:10.1016/j.humimm.2009.08.004. PMID 19683022.
Zhang ZD, Frankish A, Hunt T, Harrow J, Gerstein M (2010). "Identification and analysis of unitary pseudogenes: historic and contemporary gene losses in humans and other primates". Genome Biology. 11 (3): R26. doi:10.1186/gb-2010-11-3-r26. PMC 2864566. PMID 20210993.
Wolfkamp SC, Te Velde AA, Weersma RK, Ponsioen CY, Stokkers PC (August 2010). "Is there a role for Crohn's disease-associated autophagy genes ATG16L1 and IRGM in formation of granulomas?". European Journal of Gastroenterology & Hepatology. 22 (8): 933–7. doi:10.1097/MEG.0b013e32833775e6. PMID 20395867. S2CID 20331665.
Singh SB, Ornatowski W, Vergne I, Naylor J, Delgado M, Roberts E, et al. (December 2010). "Human IRGM regulates autophagy and cell-autonomous immunity functions through mitochondria". Nature Cell Biology. 12 (12): 1154–65. doi:10.1038/ncb2119. PMC 2996476. PMID 21102437.
Latiano A, Palmieri O, Corritore G, Valvano MR, Bossa F, Cucchiara S, et al. (July 2010). "Variants at the 3p21 locus influence susceptibility and phenotype both in adults and early-onset patients with inflammatory bowel disease". Inflammatory Bowel Diseases. 16 (7): 1108–17. doi:10.1002/ibd.21176. hdl:10533/126913. PMID 20024904. S2CID 34309305.
Delgado M, Singh S, De Haro S, Master S, Ponpuak M, Dinkins C, et al. (January 2009). "Autophagy and pattern recognition receptors in innate immunity". Immunological Reviews. 227 (1): 189–202. doi:10.1111/j.1600-065X.2008.00725.x. PMC 2788953. PMID 19120485.
Törkvist L, Halfvarson J, Ong RT, Lördal M, Sjöqvist U, Bresso F, et al. (June 2010). "Analysis of 39 Crohn's disease risk loci in Swedish inflammatory bowel disease patients". Inflammatory Bowel Diseases. 16 (6): 907–9. doi:10.1002/ibd.21105. PMID 19760754.
Budarf ML, Goyette P, Boucher G, Lian J, Graham RR, Claudio JO, et al. (January 2011). "A targeted association study in systemic lupus erythematosus identifies multiple susceptibility alleles". Genes and Immunity. 12 (1): 51–8. doi:10.1038/gene.2010.47. PMID 20962850. S2CID 20861744.
Bekpen C, Xavier RJ, Eichler EE (December 2010). "Human IRGM gene "to be or not to be"". Seminars in Immunopathology. 32 (4): 437–44. doi:10.1007/s00281-010-0224-x. PMID 20737271. S2CID 39006249.
Cleynen I, Mahachie John JM, Henckaerts L, Van Moerkercke W, Rutgeerts P, Van Steen K, Vermeire S (September 2010). "Molecular reclassification of Crohn's disease by cluster analysis of genetic variants". PLOS ONE. 5 (9): e12952. Bibcode:2010PLoSO...512952C. doi:10.1371/journal.pone.0012952. PMC 2944846. PMID 20886065.
Wagner J, Sim WH, Ellis JA, Ong EK, Catto-Smith AG, Cameron DJ, et al. (November 2010). "Interaction of Crohn's disease susceptibility genes in an Australian paediatric cohort". PLOS ONE. 5 (11): e15376. Bibcode:2010PLoSO...515376W. doi:10.1371/journal.pone.0015376. PMC 2975706. PMID 21079743.
Meggyesi N, Kiss LS, Koszarska M, Bortlik M, Duricova D, Lakatos L, et al. (November 2010). "NKX2-3 and IRGM variants are associated with disease susceptibility to IBD in Eastern European patients". World Journal of Gastroenterology. 16 (41): 5233–40. doi:10.3748/wjg.v16.i41.5233. PMC 2975094. PMID 21049557.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Hydrolases: acid anhydride hydrolases (EC 3.6)

3.6.1

3.6.2

3.6.3-4: ATPase

3.6.3

Cu++ (3.6.3.4)	Menkes/ATP7A Wilson/ATP7B
Ca+ (3.6.3.8)	SERCA ATP2A1 ATP2A2 ATP2A3 Plasma membrane ATP2B1 ATP2B2 ATP2B3 ATP2B4 SPCA ATP2C1 ATP2C2
Na+/K+ (3.6.3.9)	ATP1A1 ATP1A2 ATP1A3 ATP1A4 ATP1B1 ATP1B2 ATP1B3 ATP1B4
H+/K+ (3.6.3.10)	ATP4A
Other P-type ATPase	ATP8B1 ATP10A ATP11B ATP12A ATP13A2 ATP13A3

3.6.4

3.6.5: GTPase

3.6.5.1: Heterotrimeric G protein	G_αs G_olf G_αi GNAI1 GNAI2 GNAI3 Transducin GNAT1 GNAT2 Gustducin GNAT3 G_αq/11 GNAQ GNA11 G_α12/13 GNA12 GNA13
3.6.5.2: Small GTPase > Ras superfamily	Rho family of GTPases: Cdc42 CDC42 TC10 TCL RhoUV RhoU RhoV Rac Rac1 2 3 RhoG RhoBTB 1 2 RhoH Rho A B C Rnd 1 2 3 RhoDF RhoF RhoD other: Ras HRAS KRAS NRAS Rab RAB23 RAB27 Arf ARF6 SAR1B ARL13B ARL6 Ran Rheb Rap RGK
3.6.5.3: Protein-synthesizing GTPase	Prokaryotic IF-2 EF-Tu EF-G Eukaryotic
3.6.5.5-6: Polymerization motors	dynamin superfamily Dynamin Guanylate-binding protein Mitofusin-1 MX1 and MX2 OPA1 Tubulin

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)