GNAT3

Protein-coding gene in the species Homo sapiens
GNAT3
Identifiers
AliasesGNAT3, GDCA, G protein subunit alpha transducin 3, HG1E
External IDsOMIM: 139395 MGI: 3588268 HomoloGene: 24284 GeneCards: GNAT3
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for GNAT3
Genomic location for GNAT3
Band7q21.11Start80,458,635 bp[1]
End80,512,064 bp[1]
Gene location (Mouse)
Chromosome 5 (mouse)
Chr.Chromosome 5 (mouse)[2]
Chromosome 5 (mouse)
Genomic location for GNAT3
Genomic location for GNAT3
Band5|5 A3Start18,167,547 bp[2]
End18,224,832 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • tibialis anterior muscle

  • duodenum

  • abdominal wall

  • mucosa of small intestine

  • prefrontal cortex

  • right lobe of thyroid gland

  • left lobe of thyroid gland

  • reproductive system

  • large intestine

  • reproductive organ
Top expressed in
  • mucosa of large intestine

  • intestinal epithelium

  • tongue

  • mucosa of small intestine

  • vallate papilla

  • secondary oocyte

  • white adipose tissue

  • thymus

  • ileum

  • jejunum
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • signal transducer activity
  • metal ion binding
  • nucleotide binding
  • guanyl nucleotide binding
  • G protein-coupled receptor binding
  • G-protein beta/gamma-subunit complex binding
  • GTP binding
  • GTPase activity
Cellular component
  • acrosomal vesicle
  • cytoplasm
  • axoneme
  • heterotrimeric G-protein complex
  • apical plasma membrane
  • plasma membrane
  • photoreceptor outer segment
  • photoreceptor inner segment
  • protein-containing complex
Biological process
  • signal transduction
  • sensory perception of umami taste
  • response to nicotine
  • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
  • adenylate cyclase-modulating G protein-coupled receptor signaling pathway
  • sensory perception of bitter taste
  • sensory perception of taste
  • sensory perception of sweet taste
  • protein folding
  • detection of chemical stimulus involved in sensory perception of bitter taste
  • G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

346562

242851

Ensembl

ENSG00000214415

ENSMUSG00000028777

UniProt

A8MTJ3

Q3V3I2

RefSeq (mRNA)

NM_001102386

NM_001081143

RefSeq (protein)

NP_001095856

NP_001074612

Location (UCSC)Chr 7: 80.46 – 80.51 MbChr 5: 18.17 – 18.22 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Guanine nucleotide-binding protein G(t) subunit alpha-3, also known as gustducin alpha-3 chain, is a protein subunit that in humans is encoded by the GNAT3 gene.[5]

Gustducin alpha-3 chain is a subunit of the heterotrimeric G protein gustducin that is responsible for basic taste.

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000214415 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028777 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: guanine nucleotide binding protein".

Further reading

  • Oldham WM, Van Eps N, Preininger AM, et al. (2006). "Mechanism of the receptor-catalyzed activation of heterotrimeric G proteins". Nat. Struct. Mol. Biol. 13 (9): 772–7. doi:10.1038/nsmb1129. PMID 16892066. S2CID 290532.
  • Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
  • Rozengurt N, Wu SV, Chen MC, et al. (2006). "Colocalization of the alpha-subunit of gustducin with PYY and GLP-1 in L cells of human colon". Am. J. Physiol. Gastrointest. Liver Physiol. 291 (5): G792-802. doi:10.1152/ajpgi.00074.2006. PMID 16728727.
  • Huang L, Shanker YG, Dubauskaite J, et al. (1999). "Ggamma13 colocalizes with gustducin in taste receptor cells and mediates IP3 responses to bitter denatonium". Nat. Neurosci. 2 (12): 1055–62. doi:10.1038/15981. PMID 10570481. S2CID 24494794.
  • Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Luttrell LM (2008). "Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors". Mol. Biotechnol. 39 (3): 239–64. doi:10.1007/s12033-008-9031-1. PMID 18240029. S2CID 45173229.
  • Margolskee RF, Dyer J, Kokrashvili Z, et al. (2007). "T1R3 and gustducin in gut sense sugars to regulate expression of Na+-glucose cotransporter 1". Proc. Natl. Acad. Sci. U.S.A. 104 (38): 15075–80. Bibcode:2007PNAS..10415075M. doi:10.1073/pnas.0706678104. PMC 1986615. PMID 17724332.
  • Takami S, Getchell TV, McLaughlin SK, et al. (1994). "Human taste cells express the G protein alpha-gustducin and neuron-specific enolase". Brain Res. Mol. Brain Res. 22 (1–4): 193–203. doi:10.1016/0169-328X(94)90047-7. PMID 8015379.
  • Jang HJ, Kokrashvili Z, Theodorakis MJ, et al. (2007). "Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1". Proc. Natl. Acad. Sci. U.S.A. 104 (38): 15069–74. Bibcode:2007PNAS..10415069J. doi:10.1073/pnas.0706890104. PMC 1986614. PMID 17724330.
  • Li X, Staszewski L, Xu H, et al. (2002). "Human receptors for sweet and umami taste". Proc. Natl. Acad. Sci. U.S.A. 99 (7): 4692–6. Bibcode:2002PNAS...99.4692L. doi:10.1073/pnas.072090199. PMC 123709. PMID 11917125.
  • Fehr J, Meyer D, Widmayer P, et al. (2007). "Expression of the G-protein alpha-subunit gustducin in mammalian spermatozoa". J. Comp. Physiol. A. 193 (1): 21–34. doi:10.1007/s00359-006-0168-8. PMID 17021831. S2CID 25762931.
  • Lambright DG, Noel JP, Hamm HE, Sigler PB (1994). "Structural determinants for activation of the alpha-subunit of a heterotrimeric G protein". Nature. 369 (6482): 621–8. Bibcode:1994Natur.369..621L. doi:10.1038/369621a0. PMID 8208289. S2CID 4238569.
  • v
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MAP
  • see MAP kinase pathway
CalciumG protein
Heterotrimeric
cAMP:
cGMP:
Monomeric
CyclinLipidOther protein kinase
Serine/threonine:
Tyrosine:
Serine/threonine/tyrosine
Arginine
Other protein phosphatase
Serine/threonine:
Tyrosine:
both:
Apoptosis
  • see apoptosis signaling pathway
GTP-binding protein regulators
  • see GTP-binding protein regulators
Other
see also deficiencies of intracellular signaling peptides and proteins


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