Sodium astatide : Synthesis, Uses Wikipedia, the free encyclopedia

Sodium astatide

Inorganic compound of sodium and astatine

Sodium astatide

Names

Preferred IUPAC name

Sodium astatide

Identifiers

Properties

Chemical formula

NaAt

Related compounds

Magnesium astatide

Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Infobox references

Chemical compound

Sodium astatide is a binary inorganic compound of sodium and astatine with the chemical formula NaAt.^[1]^[2]

Synthesis

Sodium astatide solution has been prepared by distilling astatine from the bismuth alpha-ray target where it was prepared, dissolving in sodium bicarbonate solution, and reducing At⁺ and At³⁺ ions with ascorbic acid.^[3]

Uses

Sodium astatide has been proposed for use in radiation therapy to replace ¹³¹I.^[4]^[3]

References

^ Watabe, Tadashi; Hosono, Makoto; Kinuya, Seigo; Yamada, Takahiro; Yanagida, Sachiko; Namba, Masao; Nakamura, Yoshihide (July 2021). "Manual on the proper use of sodium astatide ([211At]NaAt) injections in clinical trials for targeted alpha therapy (1st edition)". Annals of Nuclear Medicine. 35 (7): 753–766. doi:10.1007/s12149-021-01619-2. ISSN 1864-6433. PMC 8197710. PMID 33978932.
^ Ball, Philip (17 March 2020). "An affinity for astatine". Chemistry World. Retrieved 16 June 2023.
^ ^a ^b Y. Shirakami. "Preparation of [211At]-labeled sodium astatide (NaAt) by reducing with ascorbic acid for the treatment of thyroid cancer" (PDF). RIKEN Accel. Prog. Rep. 53: 171. Retrieved 16 June 2023.
^ "Breakthrough alpha-ray treatment of cancer without external radiation". EurekAlert!. Retrieved 16 June 2023.

Sodium compounds

Inorganic

Halides	NaF NaHF₂ NaCl NaBr NaI NaAt
Chalcogenides	NaO₃ NaO₂ Na₂O Na₂O₂ NaOH NaOD Na₂S NaSH Na₂Se NaSeH Na₂Te NaHTe Na₂Po
Pnictogenides	Na₃N NaN₃ NaNH₂ Na₃P Na₃As
Oxyhalides	NaClO NaClO₂ NaClO₃ NaClO₄ NaBrO NaBrO₂ NaBrO₃ NaBrO₄ NaIO₃ NaIO₄
Oxychalcogenides	Na₂SO₃ Na₂SO₄ NaHSO₃ NaHSO₄ Na₂S₂O₃ Na₂S₂O₄ Na₂S₂O₅ Na₂S₂O₆ Na₂S₂O₇ Na₂S₂O₈ Na₂SeO₃ Na₂SeO₄ NaHSeO₃ Na₂TeO₃
Oxypnictogenides	NaNO₂ NaNO₃ Na₂N₂O₂ NaH₂PO₄ NaPO₂H₂ Na₂HPO₃ Na₂PO₃F Na₃PS₂O₂ Na₃PO₄ Na₅P₃O₁₀ Na₄P₂O₇ Na₂H₂P₂O₇ Na₃AsO₃ Na₃AsO₄ Na₂HAsO₄ NaH₂AsO₄ NaSbO₃
Others	NaAlH₄ NaAlO₂ Na₃AlF₆ NaAl(SO₄)₂ NaAuCl₄ Na₂TiF₆ NaBH₄ NaBH₃(CN) NaBO₂ Na₂B₄O₇ Na₂B₂O₉ Na₂B₈O₁₃ NaBiO₃ NaCN NaCNO NaCoO₂ NaH NaHCO₃ Na₄XeO₆ NaHXeO₄ NaMnO₄ NaOCN NaReO₄ NaSCN NaTcO₃ NaTcO₄ NaVO₃ Na₂CO₃ Na₂C₂O₄ Na₂C₃S₅ Na₂CrO₄ Na₂Cr₂O₇ Na₂Cr₃O₁₀ Na₂GeO₃ Na₂He Na₂[Fe(CO)₄] Na₂MnO₄ Na₂MoO₄ Na₃IrCl₆ Na₂PtCl₆ Na₂O(UO₃)₂ Na₂S₄O₆ Na₂SiO₃ Na₂TiO₃ Na₂U₂O₇ Na₂WO₄ Na₂Zn(OH)₄ Na₃VO₄ Na₆V₁₀O₂₈ Na₄Fe(CN)₆ Na₃Fe(CN)₆ Na₃Fe(C₂O₄)₃ Na₄SiO₄ Na₂SiF₆ Na₃[Co(NO₂)₆] NaNSi₆ Na₂PdCl₄