Pregnenolone acetate
Chemical compound
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| Trade names | Antofin, Previsone, Pregno-Pan |
| Other names | Pregn-5-en-3β-ol-20-one 3β-acetate, Antofin, Artivis, Enescorb, Previsone, Sharmone, Pregnenolone-3-acetate, 1778-02-5, 3α-Acetoxy-5-pregnen-20-one, ZINC6304690, NSC 64827, Acetic acid 20-oxopregn-5-en-3alpha-yl ester[1] |
| Routes of administration | Topical |
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| ECHA InfoCard | 100.015.648  |
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| Formula | C23H34O3 |
| Molar mass | 358.522 g·mol−1 |
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Pregnenolone acetate (brand names Antofin, Previsone, Pregno-Pan), also known as pregn-5-en-3β-ol-20-one 3β-acetate, is a synthetic pregnane steroid and an ester of pregnenolone which is described as a glucocorticoid and as a skin-conditioning and skin anti-aging agent.[2][3] It has been reported to reduce wrinkles in elderly women when applied in the form of a 0.5% topical cream, effects which were suggested to be due to improved hydration of the skin.[3] Pregnenolone acetate has been marketed in France in a topical cream containing 1% pregnenolone acetate and 10% "sex hormone" for the treatment of premature skin aging but was withdrawn from the market in 1992.[3] Although the medication has been described by some sources as a glucocorticoid, other authors have stated that systemic pregnenolone acetate has no undesirable metabolic or toxic effects even at high doses.[4]
See also
References
- ^ National Center for Biotechnology Information. PubChem Compound Database; CID=11013784, https://pubchem.ncbi.nlm.nih.gov/compound/11013784 (accessed Mar. 10, 2019).
- ^ J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 665–. ISBN 978-1-4757-2085-3.
- ^ a b c Council of Europe. Committee of Experts on Cosmetic Products (2008). Active Ingredients Used in Cosmetics: Safety Survey. Council of Europe. pp. 325–. ISBN 978-92-871-6298-4.
- ^ Lamb JH, Kelly FC, Shackelford PO, Rebell G, Koons RC (1953). "Pregnenolone acetate in treatment of mycetoma (nocardiosis)". AMA Arch Derm Syphilol. 67 (2): 141–5. doi:10.1001/archderm.1953.01540020019004. PMID 13029897.
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Other dermatological preparations (D11)
- Abrocitinib
- Aminobenzoate potassium
- Androgens (e.g., testosterone)
- Brimonidine
- Caffeine
- Calcium gluconate
- Collagen
- Crisaborole
- Cromoglicic acid
- Deoxycholic acid
- Diclofenac
- Dupilumab
- Estrogens (e.g., estradiol)
- Glycopyrronium tosylate
- Hyaluronic acid
- Hydrogen peroxide
- Ivermectin
- Magnesium sulfate
- Metandienone
- Oxymetazoline
- Pregnenolone acetate
- Progestogens (e.g., progesterone)
- Povidone-iodine
- Tiratricol
- Tralokinumab
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