Astromicin

Chemical compound
  • none
Legal statusLegal status
  • In general: ℞ (Prescription only)
Identifiers
  • 2-Amino-N-[(1S,2R,3R,4S,5S,6R)-4-amino-3-[(2R,3R,6S)-3-amino-6-(1-aminoethyl)oxan-2-yl]oxy-2,5-dihydroxy-6-methoxycyclohexyl]-N-methylacetamide
CAS Number
  • 55779-06-1 ☒N
PubChem CID
  • 65345
ChemSpider
  • 4447577 checkY
UNII
  • 7JHD84H15J
KEGG
  • D07470 checkY
ChEBI
  • CHEBI:37923 ☒N
ChEMBL
  • ChEMBL1909053 ☒N
CompTox Dashboard (EPA)
  • DTXSID2022624 Edit this at Wikidata
Chemical and physical dataFormulaC17H35N5O6Molar mass405.496 g·mol−13D model (JSmol)
  • Interactive image
  • O=C(N(C)[C@@H]2[C@@H](OC)[C@@H](O)[C@H](N)[C@@H](O[C@H]1O[C@H]([C@@H](N)C)CC[C@H]1N)[C@@H]2O)CN
InChI
  • InChI=1S/C17H35N5O6/c1-7(19)9-5-4-8(20)17(27-9)28-15-11(21)13(24)16(26-3)12(14(15)25)22(2)10(23)6-18/h7-9,11-17,24-25H,4-6,18-21H2,1-3H3/t7-,8+,9-,11-,12-,13-,14+,15+,16+,17+/m0/s1 checkY
  • Key:BIDUPMYXGFNAEJ-APGVDKLISA-N checkY
 ☒NcheckY (what is this?)  (verify)

Astromicin (INN; also frequently referenced in scientific journal articles as compounds Fortimicin A/B ) is an aminoglycoside antibiotic. It is produce by Micromonospora olivasterospora (also named with additional o in olivoasterospora).[1][2]

References

  1. ^ Itoh S, Odakura Y, Kase H, Satoh S, Takahashi K, Iida T, Shirahata K, Nakayama K (December 1984). "Biosynthesis of astromicin and related antibiotics. I. Biosynthetic studies by bioconversion experiments". The Journal of Antibiotics. 37 (12): 1664–9. doi:10.7164/antibiotics.37.1664. PMID 6526734.
  2. ^ Odakura Y, Kase H, Itoh S, Satoh S, Takasawa S, Takahashi K, Shirahata K, Nakayama K (December 1984). "Biosynthesis of astromicin and related antibiotics. II. Biosynthetic studies with blocked mutants of Micromonospora olivasterospora". The Journal of Antibiotics. 37 (12): 1670–80. doi:10.7164/antibiotics.37.1670. PMID 6526735.
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Antibacterials that inhibit protein synthesis (J01A, J01B, J01F, J01G, QJ01XQ)
30S
Aminoglycosides
(initiation inhibitors)
-mycin (Streptomyces)
-micin (Micromonospora)
other
Tetracycline antibiotics
(tRNA binding)
Tetracyclines
Glycylcyclines
50S
Oxazolidinone
(initiation inhibitors)
Peptidyl transferase
Amphenicols
Pleuromutilins
MLS (transpeptidation/translocation)
Macrolides
Ketolides
Lincosamides
Streptogramins
EF-G
Steroid antibacterials