Butaxamine

Mixture of isomers

None

Identifiers

IUPAC name

(1S,2S)-1-(2,5-dimethoxyphenyl)-2-
(tert-butylamino)propan-1-ol

CAS Number

2922-20-5^Y

PubChem CID

21909

ChemSpider

20593^Y

UNII

0NM31M53PW

ChEMBL

ChEMBL289093

Chemical and physical dataFormulaC₁₅H₂₅NO₃Molar mass267.369 g·mol⁻¹3D model (JSmol)

Interactive image

SMILES

Cl.O(c1ccc(OC)cc1C(O)C(NC(C)(C)C)C)C

InChI

InChI=1S/C15H25NO3.ClH/c1-10(16-15(2,3)4)14(17)12-9-11(18-5)7-8-13(12)19-6;/h7-10,14,16-17H,1-6H3;1H^Y
Key:URPAECSKKQLCII-UHFFFAOYSA-N^Y

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Butaxamine (INN, also known as butoxamine) is a β₂-selective beta blocker.^[1]^[2] Its primary use is in experimental situations in which blockade of β₂ receptors is necessary to determine the activity of the drug (i.e. if the β₂ receptor is completely blocked, but the given effect is still present, the given effect is not a characteristic of the β₂ receptor). It has no clinical use. An alternative name is α-(1-[tert-butylamino]ethyl)-2,5-dimethoxybenzyl alcohol.

References

^ "Definition: butoxamine from Online Medical Dictionary".
^ Hillman KL, Doze VA, Porter JE (August 2005). "Functional characterization of the beta-adrenergic receptor subtypes expressed by CA1 pyramidal cells in the rat hippocampus". J. Pharmacol. Exp. Ther. 314 (2): 561–7. doi:10.1124/jpet.105.084947. PMID 15908513. S2CID 12446381.