Interleukin 1 receptor, type I

Type of interleukin receptor
IL1R1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1G0Y, 1IRA, 1ITB, 4DEP, 4GAF

Identifiers
AliasesIL1R1, CD121A, D2S1473, IL-1R-alpha, IL1R, IL1RA, P80, Interleukin 1 receptor, type I, interleukin 1 receptor type 1
External IDsOMIM: 147810 MGI: 96545 HomoloGene: 677 GeneCards: IL1R1
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for IL1R1
Genomic location for IL1R1
Band2q11.2-q12.1Start102,064,544 bp[1]
End102,179,874 bp[1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[2]
Chromosome 1 (mouse)
Genomic location for IL1R1
Genomic location for IL1R1
Band1 B|1 18.81 cMStart40,225,080 bp[2]
End40,317,257 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • palpebral conjunctiva

  • tibia

  • pericardium

  • corpus epididymis

  • caput epididymis

  • urethra

  • vena cava

  • visceral pleura

  • parietal pleura

  • germinal epithelium
Top expressed in
  • islet of Langerhans

  • seminal vesicula

  • belly cord

  • medullary collecting duct

  • aortic valve

  • ciliary body

  • cumulus cell

  • secondary oocyte

  • hair follicle

  • lacrimal gland
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • interleukin-1, type I, activating receptor activity
  • signal transducer activity
  • platelet-derived growth factor receptor binding
  • protease binding
  • protein binding
  • transmembrane signaling receptor activity
  • interleukin-1 receptor activity
  • interleukin-1 binding
Cellular component
  • integral component of membrane
  • membrane
  • plasma membrane
  • integral component of plasma membrane
  • extracellular region
  • cell surface
  • external side of plasma membrane
Biological process
  • cell surface receptor signaling pathway
  • immune response
  • regulation of inflammatory response
  • signal transduction
  • positive regulation of interleukin-1-mediated signaling pathway
  • positive regulation of neutrophil extravasation
  • response to interleukin-1
  • cytokine-mediated signaling pathway
  • interleukin-1-mediated signaling pathway
  • positive regulation of interferon-gamma production
  • positive regulation of T-helper 1 cell cytokine production
  • inflammatory response
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

3554

16177

Ensembl

ENSG00000115594

ENSMUSG00000026072

UniProt

P14778

P13504

RefSeq (mRNA)
NM_000877
NM_001288706
NM_001320978
NM_001320980
NM_001320981

NM_001320982
NM_001320983
NM_001320984
NM_001320985
NM_001320986

NM_001123382
NM_008362

RefSeq (protein)
NP_000868
NP_001275635
NP_001307907
NP_001307909
NP_001307910

NP_001307911
NP_001307912
NP_001307913
NP_001307914
NP_001307915

NP_001116854
NP_032388

Location (UCSC)Chr 2: 102.06 – 102.18 MbChr 1: 40.23 – 40.32 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interleukin 1 receptor, type I (IL1R1) also known as CD121a (Cluster of Differentiation 121a), is an interleukin receptor. IL1R1 also denotes its human gene.[5]

The protein encoded by this gene is a cytokine receptor that belongs to the interleukin-1 receptor family. This protein is a receptor for interleukin 1 alpha (IL1A), interleukin 1 beta (IL1B), and interleukin 1 receptor antagonist (IL1RA). It is an important mediator involved in many cytokine induced immune and inflammatory responses. This gene along with interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 2 (IL1RL2), and interleukin 1 receptor-like 1 (IL1RL1) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12.[5]

Interactions

Interleukin 1 receptor, type I has been shown to interact with PIK3R1,[6] Myd88[7][8] and IL1RAP.[9]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000115594 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026072 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: IL1R1 interleukin 1 receptor, type I".
  6. ^ Reddy, S A; Huang J H; Liao W S (November 1997). "Phosphatidylinositol 3-kinase in interleukin 1 signaling. Physical interaction with the interleukin 1 receptor and requirement in NFkappaB and AP-1 activation". J. Biol. Chem. 272 (46). UNITED STATES: 29167–73. doi:10.1074/jbc.272.46.29167. ISSN 0021-9258. PMID 9360994.
  7. ^ Burns, K; Clatworthy J; Martin L; Martinon F; Plumpton C; Maschera B; Lewis A; Ray K; Tschopp J; Volpe F (June 2000). "Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor". Nat. Cell Biol. 2 (6). ENGLAND: 346–51. doi:10.1038/35014038. ISSN 1465-7392. PMID 10854325. S2CID 32036101.
  8. ^ Muzio, M; Ni J; Feng P; Dixit V M (November 1997). "IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling". Science. 278 (5343). UNITED STATES: 1612–5. Bibcode:1997Sci...278.1612M. doi:10.1126/science.278.5343.1612. ISSN 0036-8075. PMID 9374458.
  9. ^ Huang, J; Gao X; Li S; Cao Z (November 1997). "Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein". Proc. Natl. Acad. Sci. U.S.A. 94 (24). UNITED STATES: 12829–32. Bibcode:1997PNAS...9412829H. doi:10.1073/pnas.94.24.12829. ISSN 0027-8424. PMC 24223. PMID 9371760.

Further reading

  • Copeland NG, Silan CM, Kingsley DM, et al. (1991). "Chromosomal location of murine and human IL-1 receptor genes". Genomics. 9 (1): 44–50. doi:10.1016/0888-7543(91)90219-5. PMID 1672292.
  • McMahan CJ, Slack JL, Mosley B, et al. (1991). "A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types". EMBO J. 10 (10): 2821–32. doi:10.1002/j.1460-2075.1991.tb07831.x. PMC 452992. PMID 1833184.
  • Uhl J, Newton RC, Giri JG, et al. (1989). "Identification of IL-1 receptors on human monocytes". J. Immunol. 142 (5): 1576–81. doi:10.4049/jimmunol.142.5.1576. PMID 2521881. S2CID 28462235.
  • Sims JE, Acres RB, Grubin CE, et al. (1989). "Cloning the interleukin 1 receptor from human T cells". Proc. Natl. Acad. Sci. U.S.A. 86 (22): 8946–50. Bibcode:1989PNAS...86.8946S. doi:10.1073/pnas.86.22.8946. PMC 298407. PMID 2530587.
  • Chua AO, Gubler U (1990). "Sequence of the cDNA for the human fibroblast type interleukin-1 receptor". Nucleic Acids Res. 17 (23): 10114. doi:10.1093/nar/17.23.10114. PMC 335251. PMID 2532321.
  • Dower SK, Kronheim SR, Hopp TP, et al. (1987). "The cell surface receptors for interleukin-1 alpha and interleukin-1 beta are identical". Nature. 324 (6094): 266–8. Bibcode:1986Natur.324..266D. doi:10.1038/324266a0. PMID 2946959. S2CID 4233242.
  • Rautonen N, Rautonen J, Martin NL, Wara DW (1995). "HIV-1 Tat induces cytokine synthesis by uninfected mononuclear cells". AIDS. 8 (10): 1504–6. doi:10.1097/00002030-199410000-00023. PMID 7818827.
  • Vigers GP, Anderson LJ, Caffes P, Brandhuber BJ (1997). "Crystal structure of the type-I interleukin-1 receptor complexed with interleukin-1beta". Nature. 386 (6621): 190–4. Bibcode:1997Natur.386..190V. doi:10.1038/386190a0. PMID 9062193. S2CID 4358379.
  • Schreuder H, Tardif C, Trump-Kallmeyer S, et al. (1997). "A new cytokine-receptor binding mode revealed by the crystal structure of the IL-1 receptor with an antagonist". Nature. 386 (6621): 194–200. Bibcode:1997Natur.386..194S. doi:10.1038/386194a0. PMID 9062194. S2CID 4266953.
  • Rameshwar P, Poddar A, Zhu G, Gascón P (1997). "Receptor induction regulates the synergistic effects of substance P with IL-1 and platelet-derived growth factor on the proliferation of bone marrow fibroblasts". J. Immunol. 158 (7): 3417–24. doi:10.4049/jimmunol.158.7.3417. PMID 9120302. S2CID 24164798.
  • Reddy SA, Huang JH, Liao WS (1997). "Phosphatidylinositol 3-kinase in interleukin 1 signaling. Physical interaction with the interleukin 1 receptor and requirement in NFkappaB and AP-1 activation". J. Biol. Chem. 272 (46): 29167–73. doi:10.1074/jbc.272.46.29167. PMID 9360994.
  • Huang J, Gao X, Li S, Cao Z (1998). "Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein". Proc. Natl. Acad. Sci. U.S.A. 94 (24): 12829–32. Bibcode:1997PNAS...9412829H. doi:10.1073/pnas.94.24.12829. PMC 24223. PMID 9371760.
  • Muzio M, Ni J, Feng P, Dixit VM (1997). "IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling". Science. 278 (5343): 1612–5. Bibcode:1997Sci...278.1612M. doi:10.1126/science.278.5343.1612. PMID 9374458.
  • Dale M, Nicklin MJ (1999). "Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q". Genomics. 57 (1): 177–9. doi:10.1006/geno.1999.5767. PMID 10191101.
  • Sizemore N, Leung S, Stark GR (1999). "Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-kappaB p65/RelA subunit". Mol. Cell. Biol. 19 (7): 4798–805. doi:10.1128/mcb.19.7.4798. PMC 84278. PMID 10373529.
  • Burns K, Clatworthy J, Martin L, et al. (2000). "Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor". Nat. Cell Biol. 2 (6): 346–51. doi:10.1038/35014038. PMID 10854325. S2CID 32036101.
  • Vigers GP, Dripps DJ, Edwards CK, Brandhuber BJ (2001). "X-ray crystal structure of a small antagonist peptide bound to interleukin-1 receptor type 1". J. Biol. Chem. 275 (47): 36927–33. doi:10.1074/jbc.M006071200. PMID 10903327.
  • Lin H, Ho AS, Haley-Vicente D, et al. (2001). "Cloning and characterization of IL-1HY2, a novel interleukin-1 family member". J. Biol. Chem. 276 (23): 20597–602. doi:10.1074/jbc.M010095200. PMID 11278614.
  • Joos L, McIntyre L, Ruan J, et al. (2001). "Association of IL-1beta and IL-1 receptor antagonist haplotypes with rate of decline in lung function in smokers". Thorax. 56 (11): 863–6. doi:10.1136/thorax.56.11.863. PMC 1745962. PMID 11641511.
  • Köller M, Kutscha-Lissberg F, Brom J, et al. (2003). "Influence of low molecular weight heparin (certoparin) and unfractionated heparin on the release of cytokines from human leukocytes". Inflammation. 25 (5): 331–7. doi:10.1023/A:1012883916991. PMID 11820460. S2CID 21831719.
  • v
  • t
  • e
  • 1g0y: IL-1 RECEPTOR TYPE 1 COMPLEXED WITH ANTAGONIST PEPTIDE AF10847
    1g0y: IL-1 RECEPTOR TYPE 1 COMPLEXED WITH ANTAGONIST PEPTIDE AF10847
  • 1ira: COMPLEX OF THE INTERLEUKIN-1 RECEPTOR WITH THE INTERLEUKIN-1 RECEPTOR ANTAGONIST (IL1RA)
    1ira: COMPLEX OF THE INTERLEUKIN-1 RECEPTOR WITH THE INTERLEUKIN-1 RECEPTOR ANTAGONIST (IL1RA)
  • 1itb: TYPE-1 INTERLEUKIN-1 RECEPTOR COMPLEXED WITH INTERLEUKIN-1 BETA
    1itb: TYPE-1 INTERLEUKIN-1 RECEPTOR COMPLEXED WITH INTERLEUKIN-1 BETA

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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