EPH receptor A2

EPHA2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1MQB, 2E8N, 2K9Y, 2KSO, 2X10, 2X11, 3C8X, 3CZU, 3FL7, 3HEI, 3HPN, 3KKA, 3MBW, 3MX0, 3SKJ, 4P2K, 4PDO, 4TRL, 5EK7
Identifiers
Aliases	EPHA2, Epha2, AW545284, Eck, Myk2, Sek-2, Sek2, ARCC2, CTPA, CTPP1, CTRCT6, EPH receptor A2, ECK
External IDs	OMIM: 176946 MGI: 95278 HomoloGene: 20929 GeneCards: EPHA2
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.13 Start 16,124,337 bp[1] End 16,156,069 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 D3|4 73.67 cM Start 141,028,551 bp[2] End 141,056,695 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in vagina gallbladder skin of abdomen cervix epithelium salivary gland minor salivary glands trachea oral cavity gums parotid gland Top expressed in neural plate lip lens hair follicle jejunum duodenum esophagus right lung yolk sac mesoderm More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding protein kinase activity transferase activity kinase activity protein binding protein tyrosine kinase activity ATP binding ephrin receptor activity transmembrane receptor protein tyrosine kinase activity cadherin binding virus receptor activity transmembrane-ephrin receptor activity Cellular component integral component of membrane cell projection membrane ruffle membrane cell junction lamellipodium membrane leading edge membrane focal adhesion integral component of plasma membrane intracellular anatomical structure plasma membrane lamellipodium cell surface neuron projection receptor complex tight junctions Biological process regulation of lamellipodium assembly skeletal system development negative regulation of protein kinase B signaling cell differentiation regulation of cell adhesion mediated by integrin protein kinase B signaling activation of GTPase activity phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway keratinocyte differentiation vasculogenesis multicellular organism development protein phosphorylation cell adhesion blood vessel development notochord morphogenesis notochord cell development angiogenesis intrinsic apoptotic signaling pathway in response to DNA damage neural tube development neuron differentiation notochord regulation of ERK1 and ERK2 cascade cell chemotaxis post-anal tail morphogenesis axial mesoderm formation response to growth factor viral process cell migration apoptotic process peptidyl-tyrosine phosphorylation osteoclast differentiation osteoblast differentiation regulation of angiogenesis regulation of blood vessel endothelial cell migration ephrin receptor signaling pathway lens fiber cell morphogenesis mammary gland epithelial cell proliferation bone remodeling branching involved in mammary gland duct morphogenesis negative regulation of cytokine production defense response to Gram-positive bacterium negative regulation of lymphangiogenesis blood vessel endothelial cell proliferation involved in sprouting angiogenesis pericyte cell differentiation negative regulation of angiogenesis inflammatory response negative regulation of chemokine production blood vessel morphogenesis cAMP metabolic process cell motility viral entry into host cell positive regulation of protein localization to plasma membrane axon guidance protein localization to plasma membrane positive regulation of bicellular tight junction assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1969 13836 Ensembl ENSG00000142627 ENSMUSG00000006445 UniProt P29317 Q03145 RefSeq (mRNA) NM_004431 NM_001329090 NM_010139 RefSeq (protein) NP_001316019 NP_004422 NP_034269 Location (UCSC) Chr 1: 16.12 – 16.16 Mb Chr 4: 141.03 – 141.06 Mb PubMed search [3] [4]
Wikidata
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EPH receptor A2 (ephrin type-A receptor 2) is a protein that in humans is encoded by the EPHA2 gene.^[5][6]

Function

This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into two groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands.^[6]

Clinical significance

It may be implicated in BRAF mutated melanomas becoming resistant to BRAF-inhibitors and MEK inhibitors.^[7] It is also the receptor by which Kaposi's sarcoma-associated herpesvirus (KSHV) enters host cells; small molecule inhibitors of EphA2 have shown some ability to block KSHV entry into human cells.^[8]

Interactions

EPH receptor A2 has been shown to interact with:

• Ephrin A1^[9]
• ACP1^[10]
• Grb2,^[11]
• PIK3R1,^[12] and
• SHC1.^[11]

It was also shown that doxazosin is a small molecule agonist of EPH receptor A2.^[13]

See also

• Vasculogenic mimicry

References

Further reading

External links

• Overview of all the structural information available in the PDB for UniProt: P29317 (Human Ephrin type-A receptor 2) at the PDBe-KB.
• Overview of all the structural information available in the PDB for UniProt: Q03145 (Mouse Ephrin type-A receptor 2) at the PDBe-KB.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

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