Transient neonatal diabetes
Medical condition
| Transient neonatal diabetes | |
|---|---|
 | |
| Transient neonatal diabetes mellitus is inherited in an autosomal dominant manner[1] | |
| Specialty | Pediatrics  |
Transient neonatal diabetes mellitus (TNDM) is a form of neonatal diabetes presenting at birth that is not permanent. This disease is considered to be a type of maturity onset diabetes of the young (MODY).
Types
| Type | OMIM | Gene | Locus | Description |
|---|---|---|---|---|
| TNDM1 | 601410 | ZFP57, PLAGL1 | 6p22.1, 6q24.2 | |
| TNDM2 | 610374 | ABCC8 | 11p15.1 | Due to the mutations of the other subunit of the KATP channel, SUR1, which is encoded by the ABCC8 gene.[2] |
| TNDM3 | 610582 | KCNJ11 | 11p15.1 |
Cause
This condition has to do with genetics and is often associated with having an added Chromosome 7 gene (mostly from the paternal side).[citation needed]
The form on chromosome 6 can involve imprinting.[3][4]
Diagnosis
Management
See also
References
- ^ "OMIM Entry - # 610582 - DIABETES MELLITUS, TRANSIENT NEONATAL, 3". omim.org. Retrieved 12 September 2017.
- ^ de Wet H, Proks P, Lafond M, et al. (May 2008). "A mutation (R826W) in nucleotide-binding domain 1 of ABCC8 reduces ATPase activity and causes transient neonatal diabetes". EMBO Rep. 9 (7): 648–54. doi:10.1038/embor.2008.71. PMC 2475326. PMID 18497752.
- ^ Raphaël Scharfmann (2007). Development of the Pancreas and Neonatal Diabetes. Karger Publishers. pp. 113–. ISBN 978-3-8055-8385-5. Retrieved 10 November 2010.
- ^ "Other Forms (MODY, LADA, Neonatal)". www.DiabetesCare.net. DiabetesCare.net. Retrieved 20 November 2014.
Further reading
- GeneReview/NIH/UW entry on 6q24-Related Transient Neonatal Diabetes Mellitus
