Clonixin
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Preferred IUPAC name 2-(3-Chloro-2-methylanilino)pyridine-3-carboxylic acid | |
Other names Clonixic acid; CBA 93626[1] | |
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ChEBI |
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ECHA InfoCard | 100.037.921 |
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InChI
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Properties | |
Chemical formula | C13H11ClN2O2 |
Molar mass | 262.69 g·mol−1 |
Pharmacology | |
Routes of administration | per os |
Pharmacokinetics: | |
Metabolism | Glucuronidation via UGT2B7 |
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Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is YN ?) Infobox references |
Clonixin is a nonsteroidal anti-inflammatory drug (NSAID). It also has analgesic, antipyretic, and platelet-inhibitory actions. It is used primarily in the treatment of chronic arthritic conditions and certain soft tissue disorders associated with pain and inflammation.
Synthesis
Clonixeril
The glyceryl ester of clonixin, clonixeril, is also an NSAID. It was prepared by a somewhat roundabout method.
Clonixin was reacted with chloroacetonitrile and triethylamine to give 2. Heating with potassium carbonate and glycerol acetonide displaced the activating group to produce ester 3, which was deblocked in acetic acid to produce clonixeril (4).
See also
- Flunixin
- Clonixeril
References
- ^ Finch, Jay S.; Dekornfeld, Thomas J. (1971). "Clonixin: A Clinical Evaluation of a New Oral Analgesic". The Journal of Clinical Pharmacology and New Drugs. 11 (5): 371–377. doi:10.1177/009127007101100508. hdl:2027.42/67636. PMID 4935715. S2CID 38883141. Retrieved 2015-05-21.
- ^ M. H. Sherlock, ZA 6802185 (1968); Chem. Abstr., 70: 96640c (1969).
- ^ CH 534129 (1973); Chem. Abstr., 79: 18582g (1973).
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(ligands)
DP (D2)Tooltip Prostaglandin D2 receptor |
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EP (E2)Tooltip Prostaglandin E2 receptor |
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FP (F2α)Tooltip Prostaglandin F receptor |
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IP (I2)Tooltip Prostacyclin receptor |
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TP (TXA2)Tooltip Thromboxane receptor |
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Unsorted |
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(inhibitors)
- Precursors: Linoleic acid
- γ-Linolenic acid (gamolenic acid)
- Dihomo-γ-linolenic acid
- Diacylglycerol
- Arachidonic acid
- Prostaglandin G2
- Prostaglandin H2
- See also
- Receptor/signaling modulators
- Leukotriene signaling modulators
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