Clentiazem

Clentiazem
Names
Preferred IUPAC name
(2S,3S)-8-Chloro-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate
Identifiers
CAS Number
  • 96125-53-0 checkY
3D model (JSmol)
  • Interactive image
ChemSpider
  • 51418 ☒N
PubChem CID
  • 57026
UNII
  • 40DK034DRC checkY
InChI
  • InChI=1S/C22H25ClN2O4S/c1-14(26)29-20-21(15-5-8-17(28-4)9-6-15)30-19-13-16(23)7-10-18(19)25(22(20)27)12-11-24(2)3/h5-10,13,20-21H,11-12H2,1-4H3/t20-,21+/m1/s1 ☒N
    Key: GYKFWCDBQAFCLJ-RTWAWAEBSA-N ☒N
  • InChI=1/C22H25ClN2O4S/c1-14(26)29-20-21(15-5-8-17(28-4)9-6-15)30-19-13-16(23)7-10-18(19)25(22(20)27)12-11-24(2)3/h5-10,13,20-21H,11-12H2,1-4H3/t20-,21+/m1/s1
    Key: GYKFWCDBQAFCLJ-RTWAWAEBBL
  • CC(=O)OC1C(SC2=C(C=CC(=C2)Cl)N(C1=O)CCN(C)C)C3=CC=C(C=C3)OC
Properties
Chemical formula
 C22H25ClN2O4S
Molar mass 448.9629
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
☒N verify (what is checkY☒N ?)
Infobox references
Chemical compound

Clentiazem is a calcium channel blocker.[1]

It is a chlorine derivative of diltiazem.[2]

References

  1. ^ Giasson S, Garceau D, Homsy W, Dumont L (October 1995). "Pharmacodynamics and pharmacokinetics of clentiazem and diltiazem in closed-chest anesthetized dogs". Cardiovasc Drugs Ther. 9 (5): 685–92. doi:10.1007/BF00878551. PMID 8573551. S2CID 37503776.
  2. ^ Dagenais F, Hollmann C, Buluran J, Cartier R (October 1995). "Clentiazem and diltiazem preserve endothelium-dependent relaxation following global rat heart ischemia". Can J Cardiol. 11 (9): 816–22. PMID 7585280.
  • v
  • t
  • e
Ion channel modulators
Calcium
VDCCsTooltip Voltage-dependent calcium channels
Blockers
Activators
Potassium
VGKCsTooltip Voltage-gated potassium channels
Blockers
Activators
IRKsTooltip Inwardly rectifying potassium channel
Blockers
Activators
  • GIRKTooltip G protein-coupled inwardly rectifying potassium channel-specific: ML-297 (VU0456810)
KCaTooltip Calcium-activated potassium channel
Blockers
  • BKCa-specific: Ethanol (alcohol)
  • GAL-021
Activators
K2PsTooltip Tandem pore domain potassium channel
Blockers
Activators
Sodium
VGSCsTooltip Voltage-gated sodium channels
Blockers
Activators
ENaCTooltip Epithelial sodium channel
Blockers
Activators
  • Solnatide
ASICsTooltip Acid-sensing ion channel
Blockers
Chloride
CaCCsTooltip Calcium-activated chloride channel
Blockers
Activators
CFTRTooltip Cystic fibrosis transmembrane conductance regulator
Blockers
Activators
Unsorted
Blockers
Others
TRPsTooltip Transient receptor potential channels
  • See here instead.
LGICsTooltip Ligand gated ion channels
  • See here instead.
See also: Receptor/signaling modulators • Transient receptor potential channel modulators