Terodiline

Chemical compound
  • G04BD05 (WHO)
Identifiers
  • N-tert-butyl-4,4-di(phenyl)butan-2-amine
CAS Number
  • 15793-40-5 checkY
    7082-21-5 (hydrochloride)
PubChem CID
  • 23480
ChemSpider
  • 21952 checkY
UNII
  • 70KG06964W
ChEMBL
  • ChEMBL363295 checkY
CompTox Dashboard (EPA)
  • DTXSID60860001 Edit this at Wikidata
Chemical and physical dataFormulaC20H27NMolar mass281.443 g·mol−13D model (JSmol)
  • Interactive image
  • c1ccccc1C(c2ccccc2)CC(NC(C)(C)C)C
InChI
  • InChI=1S/C20H27N/c1-16(21-20(2,3)4)15-19(17-11-7-5-8-12-17)18-13-9-6-10-14-18/h5-14,16,19,21H,15H2,1-4H3 checkY
  • Key:UISARWKNNNHPGI-UHFFFAOYSA-N checkY
  (verify)

Terodiline is a drug used in urology as an antispasmodic.

It relaxes the smooth muscle and used to reduce bladder tone in treatment of urinary frequency and incontinence. Muscle relaxation caused by terodiline, is probably due to its anticholinergic and calcium antagonist activity.

However, it also blocks IKr (Kv11.1) channels (see hERG gene) so can pose a risk for torsades de pointes. This cardiotoxicity is concentration dependent.[1]

References

  1. ^ Thomas SH, Higham PD, Hartigan-Go K, Kamali F, Wood P, Campbell RW, Ford GA (1995). "Concentration dependent cardiotoxicity of terodiline in patients treated for urinary incontinence". Br Heart J. 74 (1): 53–6. doi:10.1136/hrt.74.1.53. PMC 483946. PMID 7662454.
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Calcium
VDCCsTooltip Voltage-dependent calcium channels
Blockers
Activators
Potassium
VGKCsTooltip Voltage-gated potassium channels
Blockers
Activators
IRKsTooltip Inwardly rectifying potassium channel
Blockers
Activators
  • GIRKTooltip G protein-coupled inwardly rectifying potassium channel-specific: ML-297 (VU0456810)
KCaTooltip Calcium-activated potassium channel
Blockers
  • BKCa-specific: Ethanol (alcohol)
  • GAL-021
Activators
K2PsTooltip Tandem pore domain potassium channel
Blockers
Activators
Sodium
VGSCsTooltip Voltage-gated sodium channels
Blockers
Activators
ENaCTooltip Epithelial sodium channel
Blockers
Activators
  • Solnatide
ASICsTooltip Acid-sensing ion channel
Blockers
Chloride
CaCCsTooltip Calcium-activated chloride channel
Blockers
Activators
CFTRTooltip Cystic fibrosis transmembrane conductance regulator
Blockers
Activators
Unsorted
Blockers
Others
TRPsTooltip Transient receptor potential channels
  • See here instead.
LGICsTooltip Ligand gated ion channels
  • See here instead.
See also: Receptor/signaling modulators • Transient receptor potential channel modulators
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mAChRsTooltip Muscarinic acetylcholine receptors
Agonists
Antagonists
Precursors
(and prodrugs)
See also
Receptor/signaling modulators
Nicotinic acetylcholine receptor modulators
Acetylcholine metabolism/transport modulators


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