FZD6

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Uvojiti receptor 6
Identifikatori
SimboliFZD6; FZ-6; FZ6; HFZ6; NDNC10
Vanjski IDOMIM: 603409 MGI: 108474 HomoloGene: 2617 IUPHAR: FZD6 GeneCards: FZD6 Gene
Ontologija gena
Molekularna funkcija • aktivnost G protein spregnutog receptora
• receptorsko vezivanje
• proteinsko vezivanje
• Wnt proteinsko vezivanje
Celularna komponenta • citoplazma
• ćelijska površina
• integralno sa membranom
• sinaptosom
• membrana neuronske projekcije
Biološki proces • pozitivna regulacija proteinske fosforilacije
• razvoj vaskulature
• morfogeneza odlivnog trakta
• signalni put G protein spregnutog receptora spregnutog sa cGMP nukleotidom
Pregled RNK izražavanja
podaci
Ortolozi
VrstaČovekMiš
Entrez832314368
EnsemblENSG00000164930ENSMUSG00000022297
UniProtB4DRN0Q3UTZ0
RefSeq (mRNA)NM_001164615.1NM_001162494.1
RefSeq (protein)NP_001158087.1NP_001155966.1
Lokacija (UCSC)Chr 8:
104.31 - 104.35 Mb		Chr 15:
38.84 - 38.87 Mb
PubMed pretraga[1][2]

Uvojiti-6 je protein koji je kod ljudi kodiran FZD6 genom.[1][2][3]

Članovi familije „uvojitih“ proteina su 7-transmembranski receptori za Wnt signalne proteine. FZD6 protein sadrži signalni peptid, cisteinom bogati domen u N-terminalnom ekstracelularnom regionu i 7 transmembranski domen. Za razliku od mnogih drugih članova FZD familije, FDZ6 ne sadrži C-terminalni PDZ vezujući motif.[3] Postoje indikacije da je FZD6 protein receptor za WNT4 ligand.[4]

Interakcije

FZD6 formira interakcije sa SFRP1.[5]

Reference

  1. ↑ Tokuhara M, Hirai M, Atomi Y, Terada M, Katoh M (Mar 1998). „Molecular cloning of human Frizzled-6”. Biochem Biophys Res Commun 243 (2): 622–7. DOI:10.1006/bbrc.1998.8143. PMID 9480858. 
  2. ↑ Golan T, Yaniv A, Bafico A, Liu G, Gazit A (Apr 2004). „The human Frizzled 6 (HFz6) acts as a negative regulator of the canonical Wnt. beta-catenin signaling cascade”. J Biol Chem 279 (15): 14879–88. DOI:10.1074/jbc.M306421200. PMID 14747478. 
  3. ↑ 3,0 3,1 „Entrez Gene: FZD6 frizzled homolog 6 (Drosophila)”. 
  4. ↑ Lyons JP, Mueller UW, Ji H, Everett C, Fang X, Hsieh JC, Barth AM, McCrea PD. (Aug 2004). „WNT4 activates the canonical beta-catenin-mediated WNT pathway and binds FZD6 CRD: functional implications of Wnt/beta-catenin activity in kidney epithelial cells.”. Experimental Cell Research 298 (2): 369–387. DOI:10.1016/j.yexcr.2004.04.036. PMID 15265686. 
  5. ↑ Bafico, A; Gazit A, Pramila T, Finch P W, Yaniv A, Aaronson S A (June 1999). „Interaction of frizzled related protein (FRP) with WNT ligands and the frizzled receptor suggests alternative mechanisms for FRP inhibition of WNT signaling”. J. Biol. Chem. (UNITED STATES) 274 (23): 16180–7. DOI:10.1074/jbc.274.23.16180. ISSN 0021-9258. PMID 10347172. 

Literatura

  • Wang Y, Macke JP, Abella BS, et al. (1996). „A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled.”. J. Biol. Chem. 271 (8): 4468–76. DOI:10.1074/jbc.271.8.4468. PMID 8626800. 
  • Finch PW, He X, Kelley MJ, et al. (1997). „Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action.”. Proc. Natl. Acad. Sci. U.S.A. 94 (13): 6770–5. DOI:10.1073/pnas.94.13.6770. PMC 21233. PMID 9192640. 
  • Bafico A, Gazit A, Pramila T, et al. (1999). „Interaction of frizzled related protein (FRP) with WNT ligands and the frizzled receptor suggests alternative mechanisms for FRP inhibition of Wnt signaling.”. J. Biol. Chem. 274 (23): 16180–7. DOI:10.1074/jbc.274.23.16180. PMID 10347172. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Omoto S, Hayashi T, Kitahara K, et al. (2004). „Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R).”. Ophthalmic Genet. 25 (2): 81–90. DOI:10.1080/13816810490514270. PMID 15370539. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). „Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.”. Genome Res. 16 (1): 55–65. DOI:10.1101/gr.4039406. PMC 1356129. PMID 16344560. 
  • Sirchia R, Luparello C (2007). „Mid-region parathyroid hormone-related protein (PTHrP) and gene expression of MDA-MB231 breast cancer cells.”. Biol. Chem. 388 (5): 457–65. DOI:10.1515/BC.2007.059. PMID 17516841. 

Vidi još

Spoljašnje veze

  • „Frizzled Receptors: FZD6”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-01-24. 
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Klasa A: Rodopsinu slični
α1 (A, B, D) • α2 (A, B, C) • β1 • β2 • β3
Adenozinski (A1, A2A, A2B, A3) • P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
(svi osim 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7)
Drugi
Acetilholin (M1, M2, M3, M4, M5) • Dopamin (D1, D2, D3, D4, D5) • Histamin (H1, H2, H3, H4) • Melatonin (1A, 1B, 1C) • TAAR (1, 2, 3, 5, 6, 8, 9)
Metaboliti i
signalni molekuli
CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) • Prostaciklin • Tromboksan
Drugi
Žučna kiselina • Kanabinoidni (CB1, CB2, GPR (18, 55, 119)) • EBI2 • Estrogen • Slobodna masna kiselina (1, 2, 3, 4) • Laktat  • Lizofosfatidna kiselina (1, 2, 3, 4, 5, 6)  • Lizofosfolipid (1, 2, 3, 4, 5, 6, 7, 8) • Niacin (1, 2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1, 2, 3, 4, 5) • Sukcinat
Peptid
B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5) • Neuromedin (B, U (1, 2)) • Neurotenzin (1, 2)
Drugi
Anafilatoksin (C3a, C5a) • Angiotenzin (1, 2) • Apelin • Bombezin (BRS3, GRPR, NMBR) • Bradikinin (B1, B2) • Hemokin • Holecistokinin (A, B) • Endotelin (A, B) • Formil peptid (1, 2, 3) • FSH • Galanin (1, 2, 3) • GHB receptor • Gonadotropin-oslobađajući hormon (1, 2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) • Melanokortin (1, 2, 3, 4, 5) • MCHR (1, 2) • Motilin • Opioidni (δ, κ, μ, Nociceptin & ζ, ali ne σ) • Oreksin (1, 2) • Oksitocin • Prokineticin (1, 2) • Prolaktin-oslobađajući peptid • Relaksin (1, 2, 3, 4) • Somatostatin (1, 2, 3, 4, 5) • Tahikinin (1, 2, 3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A, 1B, 2)
Razno
GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Drugi
Adrenomedulin • Mirisni • Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Proteazom-aktivirani (1, 2, 3, 4) • SREB (1, 2, 3)
Klasa B: Sekretinu slični
GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Drugi
Klasa C: Metabotropni
glutamat / feromon
TAS1R (1, 2, 3) • TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Drugi
Klasa F:
Frizzled / Zaglađeni
Uvojiti
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Zaglađeni
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)