PRRP

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Prolaktin-oslobađajući hormonski receptor
Identifikatori
SimboliPRLHR; GPR10; GR3; MGC126539; MGC126541; PrRPR
Vanjski IDOMIM: 600895 MGI: 2135956 HomoloGene: 3134 IUPHAR: PRRP GeneCards: PRLHR Gene
Ontologija gena
Molekularna funkcija • aktivnost rodopsinu-sličnog receptora
• receptorska aktivnost
• aktivnost neuropeptid Y receptora
Celularna komponenta • integralno sa ćelijskom membranom
• membrana
Biološki proces • prenos signala
• signalni put G-protein spregnutog receptora
• trudnoća
• način ishrane
• hormonski metabolički proces
Ortolozi
VrstaČovekMiš
Entrez2834226278
EnsemblENSG00000119973ENSMUSG00000045052
UniProtP49683Q059H6
RefSeq (mRNA)NM_004248NM_201615
RefSeq (protein)NP_004239NP_963909
Lokacija (UCSC)Chr 10:
120.34 - 120.34 Mb		Chr 19:
60.52 - 60.52 Mb
PubMed pretraga[1][2]

PRRP, prolaktin-oslobađajući hormonski receptor, je G-protein spregnuti receptor[1] koji vezuje prolaktin oslobađajući hormon.[2]

PRLHR je 7-transmembranski receptor za prolaktin-oslobađajući hormon (PRLH; MIM 602663). On je visoko izražen u prednjoj hipofizi.[3][4]

Reference

  1. ↑ Marchese A, Heiber M, Nguyen T, Heng HH, Saldivia VR, Cheng R, Murphy PM, Tsui LC, Shi X, Gregor P (1995). „Cloning and chromosomal mapping of three novel genes, GPR9, GPR10, and GPR14, encoding receptors related to interleukin 8, neuropeptide Y, and somatostatin receptors”. Genomics 29 (2): 335–44. DOI:10.1006/geno.1995.9996. PMID 8666380. 
  2. ↑ Hinuma S, Habata Y, Fujii R, Kawamata Y, Hosoya M, Fukusumi S, Kitada C, Masuo Y, Asano T, Matsumoto H, Sekiguchi M, Kurokawa T, Nishimura O, Onda H, Fujino M (1998). „A prolactin-releasing peptide in the brain”. Nature 393 (6682): 272–6. DOI:10.1038/30515. PMID 9607765. 
  3. ↑ Ozawa A, Yamada M, Satoh T, et al. (April 2002). „Transcriptional regulation of the human PRL-releasing peptide (PrRP) receptor gene by a dopamine 2 Receptor agonist: cloning and characterization of the human PrRP receptor gene and its promoter region”. Molecular Endocrinology (Baltimore, Md.) 16 (4): 785–98. PMID 11923475. Pristupljeno 2011-03-28. [mrtav link]
  4. ↑ „Entrez Gene: PRLHR prolactin releasing hormone receptor”. 

Literatura

  • Hinuma S, Onda H, Fujino M (1999). „The quest for novel bioactive peptides utilizing orphan seven-transmembrane-domain receptors.”. J. Mol. Med. 77 (6): 495–504. DOI:10.1007/s001090050403. PMID 10475064. 
  • Marchese A, Heiber M, Nguyen T, et al. (1996). „Cloning and chromosomal mapping of three novel genes, GPR9, GPR10, and GPR14, encoding receptors related to interleukin 8, neuropeptide Y, and somatostatin receptors.”. Genomics 29 (2): 335–44. DOI:10.1006/geno.1995.9996. PMID 8666380. 
  • Hinuma S, Habata Y, Fujii R, et al. (1998). „A prolactin-releasing peptide in the brain.”. Nature 393 (6682): 272–6. DOI:10.1038/30515. PMID 9607765. 
  • Fujii R, Fukusumi S, Hosoya M, et al. (1999). „Tissue distribution of prolactin-releasing peptide (PrRP) and its receptor.”. Regul. Pept. 83 (1): 1–10. DOI:10.1016/S0167-0115(99)00028-2. PMID 10498338. 
  • Langmead CJ, Szekeres PG, Chambers JK, et al. (2000). „Characterization of the binding of [(125)I-human prolactin releasing peptide (PrRP) to GPR10, a novel G protein coupled receptor.”]. Br. J. Pharmacol. 131 (4): 683–8. DOI:10.1038/sj.bjp.0703617. PMC 1572376. PMID 11030716. 
  • Lin SH, Arai AC, Wang Z, et al. (2001). „The carboxyl terminus of the prolactin-releasing peptide receptor interacts with PDZ domain proteins involved in alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor clustering.”. Mol. Pharmacol. 60 (5): 916–23. PMID 11641419. 
  • Takahashi K, Totsune K, Murakami O, et al. (2003). „Expression of prolactin-releasing peptide and its receptor in the human adrenal glands and tumor tissues of adrenocortical tumors, pheochromocytomas and neuroblastomas.”. Peptides 23 (6): 1135–40. DOI:10.1016/S0196-9781(02)00046-3. PMID 12126742. 
  • Kemp DM, Lin JC, Ubeda M, Habener JF (2002). „NRSF/REST confers transcriptional repression of the GPR10 gene via a putative NRSE/RE-1 located in the 5' promoter region.”. FEBS Lett. 531 (2): 193–8. DOI:10.1016/S0014-5793(02)03502-0. PMID 12417311. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Bhattacharyya S, Luan J, Challis B, et al. (2003). „Association of polymorphisms in GPR10, the gene encoding the prolactin-releasing peptide receptor with blood pressure, but not obesity, in a U.K. Caucasian population.”. Diabetes 52 (5): 1296–9. DOI:10.2337/diabetes.52.5.1296. PMID 12716769. 
  • Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). „The DNA sequence and comparative analysis of human chromosome 10.”. Nature 429 (6990): 375–81. DOI:10.1038/nature02462. PMID 15164054. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
  • Ellacott KL, Donald EL, Clarkson P, et al. (2005). „Characterization of a naturally-occurring polymorphism in the UHR-1 gene encoding the putative rat prolactin-releasing peptide receptor.”. Peptides 26 (4): 675–81. DOI:10.1016/j.peptides.2004.11.020. PMID 15752583. 
  • Lagerström MC, Fredriksson R, Bjarnadóttir TK, et al. (2005). „Origin of the prolactin-releasing hormone (PRLH) receptors: evidence of coevolution between PRLH and a redundant neuropeptide Y receptor during vertebrate evolution.”. Genomics 85 (6): 688–703. DOI:10.1016/j.ygeno.2005.02.007. PMID 15885496. 
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). „Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.”. Genome Res. 16 (1): 55–65. DOI:10.1101/gr.4039406. PMC 1356129. PMID 16344560. 

Spoljašnje veze

  • „Prolactin-Releasing Peptide Receptor”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-03. 
  • MeSH PRLHR+protein,+human
  • p
  • r
  • u
Klasa A: Rodopsinu slični
α1 (A, B, D) • α2 (A, B, C) • β1 • β2 • β3
Adenozinski (A1, A2A, A2B, A3) • P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
(svi osim 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7)
Drugi
Acetilholin (M1, M2, M3, M4, M5) • Dopamin (D1, D2, D3, D4, D5) • Histamin (H1, H2, H3, H4) • Melatonin (1A, 1B, 1C) • TAAR (1, 2, 3, 5, 6, 8, 9)
Metaboliti i
signalni molekuli
CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) • Prostaciklin • Tromboksan
Drugi
Žučna kiselina • Kanabinoidni (CB1, CB2, GPR (18, 55, 119)) • EBI2 • Estrogen • Slobodna masna kiselina (1, 2, 3, 4) • Laktat  • Lizofosfatidna kiselina (1, 2, 3, 4, 5, 6)  • Lizofosfolipid (1, 2, 3, 4, 5, 6, 7, 8) • Niacin (1, 2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1, 2, 3, 4, 5) • Sukcinat
Peptid
B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5) • Neuromedin (B, U (1, 2)) • Neurotenzin (1, 2)
Drugi
Anafilatoksin (C3a, C5a) • Angiotenzin (1, 2) • Apelin • Bombezin (BRS3, GRPR, NMBR) • Bradikinin (B1, B2) • Hemokin • Holecistokinin (A, B) • Endotelin (A, B) • Formil peptid (1, 2, 3) • FSH • Galanin (1, 2, 3) • GHB receptor • Gonadotropin-oslobađajući hormon (1, 2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) • Melanokortin (1, 2, 3, 4, 5) • MCHR (1, 2) • Motilin • Opioidni (δ, κ, μ, Nociceptin & ζ, ali ne σ) • Oreksin (1, 2) • Oksitocin • Prokineticin (1, 2) • Prolaktin-oslobađajući peptid • Relaksin (1, 2, 3, 4) • Somatostatin (1, 2, 3, 4, 5) • Tahikinin (1, 2, 3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A, 1B, 2)
Razno
GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Drugi
Adrenomedulin • Mirisni • Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Proteazom-aktivirani (1, 2, 3, 4) • SREB (1, 2, 3)
Klasa B: Sekretinu slični
GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Drugi
Klasa C: Metabotropni
glutamat / feromon
TAS1R (1, 2, 3) • TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Drugi
Klasa F:
Frizzled / Zaglađeni
Uvojiti
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Zaglađeni
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)