FZD7

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Uvojiti receptor 7
Identifikatori
SimboliFZD7; FzE3
Vanjski IDOMIM: 603410 MGI: 108570 HomoloGene: 20751 IUPHAR: FZD7 GeneCards: FZD7 Gene
Ontologija gena
Molekularna funkcija • aktivnost G protein spregnutog receptora
• receptorsko vezivanje
• proteinsko vezivanje
• Wnt proteinsko vezivanje
• vezivanje PDZ domena
Celularna komponenta • citoplazma
• ćelijska površina
• integralno sa membranom
• sinaptosom
• membrana neuronske projekcije
Biološki proces • pozitivna regulacija proteinske fosforilacije
• razvoj vaskulature
• morfogeneza odlivnog trakta
• signalni put G protein spregnutog receptora spregnutog sa cGMP nukleotidom
Pregled RNK izražavanja
podaci
Ortolozi
VrstaČovekMiš
Entrez832414369
EnsemblENSG00000155760ENSMUSG00000041075
UniProtO75084Q810L8
RefSeq (mRNA)NM_003507.1NM_008057.3
RefSeq (protein)NP_003498.1NP_032083.3
Lokacija (UCSC)Chr 2:
202.9 - 202.9 Mb		Chr 1:
59.54 - 59.54 Mb
PubMed pretraga[1][2]

Uvojiti-7 je protein koji je kod ljudi kodiran FZD7 genom.[1][2][3]

Članovi familije „uvojitih“ proteina su 7-transmembranski receptori za Wnt signalne proteine. FZD7 protein sadrži signalni peptid, cisteinom bogati domen u N-terminalnom ekstracelularnom regionu, 7 transmembranski domen, i C-terminalni PDZ vezujući motiv. Izražavanje FZD7 gena može da umanji APC funkciju i pojača beta-katenin-posredovane signale u slabo diferenciranom ljudskim karcinomima jednjaka.[3]

Interakcije

FZD7 formira interakcije sa DLG4.[4]

Reference

  1. ↑ Tanaka S, Akiyoshi T, Mori M, Wands JR, Sugimachi K (September 1998). „A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals”. Proc Natl Acad Sci U S A 95 (17): 10164–9. DOI:10.1073/pnas.95.17.10164. PMC 21479. PMID 9707618. 
  2. ↑ Sagara N, Toda G, Hirai M, Terada M, Katoh M (December 1998). „Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7”. Biochem Biophys Res Commun 252 (1): 117–22. DOI:10.1006/bbrc.1998.9607. PMID 9813155. 
  3. ↑ 3,0 3,1 „Entrez Gene: FZD7 frizzled homolog 7 (Drosophila)”. 
  4. ↑ Hering, Heike; Sheng Morgan (June 2002). „Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95”. FEBS Lett. (Netherlands) 521 (1–3): 185–9. DOI:10.1016/S0014-5793(02)02831-4. ISSN 0014-5793. PMID 12067714. 

Literatura

  • Finch PW, He X, Kelley MJ, et al. (1997). „Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action”. Proc. Natl. Acad. Sci. U.S.A. 94 (13): 6770–5. DOI:10.1073/pnas.94.13.6770. PMC 21233. PMID 9192640. 
  • Hering H, Sheng M (2002). „Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95”. FEBS Lett. 521 (1–3): 185–9. DOI:10.1016/S0014-5793(02)02831-4. PMID 12067714. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Yao R, Natsume Y, Noda T (2005). „MAGI-3 is involved in the regulation of the JNK signaling pathway as a scaffold protein for frizzled and Ltap”. Oncogene 23 (36): 6023–30. DOI:10.1038/sj.onc.1207817. PMID 15195140. 
  • Omoto S, Hayashi T, Kitahara K, et al. (2004). „Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R)”. Ophthalmic Genet. 25 (2): 81–90. DOI:10.1080/13816810490514270. PMID 15370539. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
  • Vincan E, Darcy PK, Smyth MJ, et al. (2005). „Frizzled-7 receptor ectodomain expression in a colon cancer cell line induces morphological change and attenuates tumor growth”. Differentiation 73 (4): 142–53. DOI:10.1111/j.1432-0436.2005.00015.x. PMID 15901282. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). „Towards a proteome-scale map of the human protein-protein interaction network”. Nature 437 (7062): 1173–8. DOI:10.1038/nature04209. PMID 16189514. 
  • Lim J, Hao T, Shaw C, et al. (2006). „A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration”. Cell 125 (4): 801–14. DOI:10.1016/j.cell.2006.03.032. PMID 16713569. 
  • Vincan E, Darcy PK, Farrelly CA, et al. (2007). „Frizzled-7 dictates three-dimensional organization of colorectal cancer cell carcinoids”. Oncogene 26 (16): 2340–52. DOI:10.1038/sj.onc.1210026. PMID 17016432. 
  • Struewing IT, Barnett CD, Zhang W, et al. (2007). „Frizzled-7 turnover at the plasma membrane is regulated by cell density and the Ca(2+) -dependent protease calpain-1”. Exp. Cell Res. 313 (16): 3526–41. DOI:10.1016/j.yexcr.2007.07.012. PMID 17716656. 

Vidi još

Spoljašnje veze

  • „Frizzled Receptors: FZD7”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-03. 
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Klasa A: Rodopsinu slični
α1 (A, B, D) • α2 (A, B, C) • β1 • β2 • β3
Adenozinski (A1, A2A, A2B, A3) • P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
(svi osim 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7)
Drugi
Acetilholin (M1, M2, M3, M4, M5) • Dopamin (D1, D2, D3, D4, D5) • Histamin (H1, H2, H3, H4) • Melatonin (1A, 1B, 1C) • TAAR (1, 2, 3, 5, 6, 8, 9)
Metaboliti i
signalni molekuli
CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) • Prostaciklin • Tromboksan
Drugi
Žučna kiselina • Kanabinoidni (CB1, CB2, GPR (18, 55, 119)) • EBI2 • Estrogen • Slobodna masna kiselina (1, 2, 3, 4) • Laktat  • Lizofosfatidna kiselina (1, 2, 3, 4, 5, 6)  • Lizofosfolipid (1, 2, 3, 4, 5, 6, 7, 8) • Niacin (1, 2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1, 2, 3, 4, 5) • Sukcinat
Peptid
B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5) • Neuromedin (B, U (1, 2)) • Neurotenzin (1, 2)
Drugi
Anafilatoksin (C3a, C5a) • Angiotenzin (1, 2) • Apelin • Bombezin (BRS3, GRPR, NMBR) • Bradikinin (B1, B2) • Hemokin • Holecistokinin (A, B) • Endotelin (A, B) • Formil peptid (1, 2, 3) • FSH • Galanin (1, 2, 3) • GHB receptor • Gonadotropin-oslobađajući hormon (1, 2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) • Melanokortin (1, 2, 3, 4, 5) • MCHR (1, 2) • Motilin • Opioidni (δ, κ, μ, Nociceptin & ζ, ali ne σ) • Oreksin (1, 2) • Oksitocin • Prokineticin (1, 2) • Prolaktin-oslobađajući peptid • Relaksin (1, 2, 3, 4) • Somatostatin (1, 2, 3, 4, 5) • Tahikinin (1, 2, 3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A, 1B, 2)
Razno
GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Drugi
Adrenomedulin • Mirisni • Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Proteazom-aktivirani (1, 2, 3, 4) • SREB (1, 2, 3)
Klasa B: Sekretinu slični
GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Drugi
Klasa C: Metabotropni
glutamat / feromon
TAS1R (1, 2, 3) • TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Drugi
Klasa F:
Frizzled / Zaglađeni
Uvojiti
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Zaglađeni
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)