Metabotropni glutamatni receptor 7

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Metabotropni glutamatni receptor 7

PDB prikaz baziran na 2e4z.
Dostupne strukture
3MQ4
Identifikatori
SimboliGRM7; GLUR7; GPRC1G; MGLU7; MGLUR7
Vanjski IDOMIM: 604101 MGI: 1351344 HomoloGene: 20233 IUPHAR: mGlu7 GeneCards: GRM7 Gene
Ontologija gena
Molekularna funkcija • aktivnost grupe III metabotropnih glutamatnih receptora
• aktivnost prenosa signala
• receptorska aktivnost
• aktivnost G protein spregnutog receptora
• aktivnost naponom kontrolisanog kalcijumovog kanala
• aktivnost regulatora kalcijumovog kanala
• vezivanje jona kalcijuma
• aktivnost glutamatnog receptora
• aktivnsot inhibitor adenylat ciklaze
• glutamatno vezivanje
• vezivanje PDZ domena
• serinsko vezivanje
Celularna komponenta • ćelijska membrana
• integralno sa ćelijskom membranom
• ćelijski korteks
• integralno sa membranom
• akson
• dendrit
• asimetrična sinapsa
• presinaptička membrana
• dendritna osovina
• postsinaptička membrana
• presinaptička aktivna zona
Biološki proces • uslovna averzija ukusa
• respons na strah
• negativna regulacija aktivnosti adenilat ciklaze
• sinaptička transmisija
• senzorna percepcija zvuka
• senzorna percepcija mirisa
• kratkotrajna memorija
• negativna regulacija glutamatne sekrecije
• ponašanje odraslih
• negativna regulacija cAMP biosinthetčkog procesa
Pregled RNK izražavanja
podaci
Ortolozi
VrstaČovekMiš
Entrez2917108073
EnsemblENSG00000196277ENSMUSG00000056755
UniProtQ14831Q68ED2
RefSeq (mRNA)NM_000844.3NM_177328.3
RefSeq (protein)NP_000835.1NP_796302.2
Lokacija (UCSC)Chr 3:
6.81 - 7.78 Mb		Chr 6:
110.6 - 111.52 Mb
PubMed pretraga[1][2]

Metabotropni glutamatni receptor 7 je protein koji je kod ljudi kodiran GRM7 genom.[1][2][3]

Funkcija

L-glutamat je jedan od glavnih ekscitatornih neurotransmitera u centralnom nervnom sistemu. On aktivira jonotropne i metabotropne glutamatne receptore. Glutamatergična neurotransmisija učestvuje u većini aspekata normalih moždanih funkcija i njena perturbacija se javlja kod mnogih neuropatoloških oboljenja. Metabotropni glutamatni receptori su familija G protein spregnutih receptora, koja se deli u tri grupe na osnovu homologije sekvenci, mehanizama prenosa signala, i farmakoloških svojstava. Grupa I obuhvata GRM1 i GRM5. Ti receptori aktiviraju fosfolipazu C. Grupa II obuhvata GRM2 i GRM3, dok grupa III obuhvata GRM4, GRM6, GRM7 i GRM8. Receptori grupe II i III su povezani inhibicijom kaskade cikličnog AMP-a ali se razlikuju u njihovim selektivnostima za agoniste.[3]

Ligandi

Agonisti

Antagonisti

  • MMPIP: alosterni antagonist/inverzni agonist[7]

Interakcije

Metabotropni glutamatni receptor 7 formira interakcije sa PICK1.[8]

Reference

  1. ↑ Okamoto N, Hori S, Akazawa C, Hayashi Y, Shigemoto R, Mizuno N, Nakanishi S (February 1994). „Molecular characterization of a new metabotropic glutamate receptor mGluR7 coupled to inhibitory cyclic AMP signal transduction”. J Biol Chem 269 (2): 1231–6. PMID 8288585. 
  2. ↑ Makoff A, Pilling C, Harrington K, Emson P (January 1997). „Human metabotropic glutamate receptor type 7: molecular cloning and mRNA distribution in the CNS”. Brain Res Mol Brain Res 40 (1): 165–70. DOI:10.1016/0169-328X(96)00110-6. PMID 8840028. 
  3. ↑ 3,0 3,1 „Entrez Gene: GRM7 glutamate receptor, metabotropic 7”. 
  4. ↑ Li X, Gardner EL, Xi ZX (2008). „The Metabotropic Glutamate Receptor 7 (mGluR7) Allosteric Agonist AMN082 Modulates Nucleus Accumbens GABA and Glutamate, but not Dopamine, in Rats”. Neuropharmacology 54 (3): 542–51. DOI:10.1016/j.neuropharm.2007.11.005. PMC 2410088. PMID 18155073. 
  5. ↑ 5,0 5,1 Palucha A, Klak K, Branski P, van der Putten H, Flor PJ, Pilc A (2007). „Activation of the mGlu7 receptor elicits antidepressant-like effects in mice”. Psychopharmacology (Berl.) 194 (4): 555–62. DOI:10.1007/s00213-007-0856-2. PMID 17622518. 
  6. ↑ Pelkey KA, Yuan X, Lavezzari G, Roche KW, McBain CJ (2007). „mGluR7 undergoes rapid internalization in response to activation by the allosteric agonist AMN082”. Neuropharmacology 52 (1): 108–17. DOI:10.1016/j.neuropharm.2006.07.020. PMID 16914173. 
  7. ↑ Suzuki G, Tsukamoto N, Fushiki H et al. (2007). „In vitro pharmacological characterization of novel isoxazolopyridone derivatives as allosteric metabotropic glutamate receptor 7 antagonists”. J. Pharmacol. Exp. Ther. 323 (1): 147–56. DOI:10.1124/jpet.107.124701. PMID 17609420. 
  8. ↑ Dev, K K; Nakajima Y, Kitano J, Braithwaite S P, Henley J M, Nakanishi S (October 2000). „PICK1 interacts with and regulates PKC phosphorylation of mGLUR7”. J. Neurosci. (UNITED STATES) 20 (19): 7252–7. PMID 11007882. 

Literatura

  • Scherer SW, Duvoisin RM, Kuhn R i dr.. (1997). „Localization of two metabotropic glutamate receptor genes, GRM3 and GRM8, to human chromosome 7q”. Genomics 31 (2): 230–3. DOI:10.1006/geno.1996.0036. PMID 8824806. 
  • Flor PJ, Van Der Putten H, Rüegg D i dr.. (1997). „A novel splice variant of a metabotropic glutamate receptor, human mGluR7b”. Neuropharmacology 36 (2): 153–9. DOI:10.1016/S0028-3908(96)00176-1. PMID 9144652. 
  • Wu S, Wright RA, Rockey PK i dr.. (1998). „Group III human metabotropic glutamate receptors 4, 7 and 8: molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells”. Brain Res. Mol. Brain Res. 53 (1–2): 88–97. DOI:10.1016/S0169-328X(97)00277-5. PMID 9473604. 
  • Nakajima Y, Yamamoto T, Nakayama T, Nakanishi S (1999). „A relationship between protein kinase C phosphorylation and calmodulin binding to the metabotropic glutamate receptor subtype 7”. J. Biol. Chem. 274 (39): 27573–7. DOI:10.1074/jbc.274.39.27573. PMID 10488094. 
  • O'Connor V, El Far O, Bofill-Cardona E i dr.. (1999). „Calmodulin dependence of presynaptic metabotropic glutamate receptor signaling”. Science 286 (5442): 1180–4. DOI:10.1126/science.286.5442.1180. PMID 10550060. 
  • Barbon A, Ferraboli S, Barlati S (2000). „Assignment of the human metabotropic glutamate receptor gene GRM7 to chromosome 3p26.1→p25.2 by radiation hybrid mapping”. Cytogenet. Cell Genet. 88 (3–4): 288. DOI:10.1159/000015541. PMID 10828612. 
  • Dev KK, Nakajima Y, Kitano J i dr.. (2001). „PICK1 interacts with and regulates PKC phosphorylation of mGLUR7”. J. Neurosci. 20 (19): 7252–7. PMID 11007882. 
  • Bolonna AA, Kerwin RW, Munro J i dr.. (2001). „Polymorphisms in the genes for mGluR types 7 and 8: association studies with schizophrenia”. Schizophr. Res. 47 (1): 99–103. DOI:10.1016/S0920-9964(99)00235-2. PMID 11163549. 
  • Hirbec H, Perestenko O, Nishimune A i dr.. (2002). „The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs”. J. Biol. Chem. 277 (18): 15221–4. DOI:10.1074/jbc.C200112200. PMID 11891216. 
  • Enz R (2002). „The actin-binding protein Filamin-A interacts with the metabotropic glutamate receptor type 7”. FEBS Lett. 514 (2–3): 184–8. DOI:10.1016/S0014-5793(02)02361-X. PMID 11943148. 
  • Saugstad JA, Yang S, Pohl J i dr.. (2002). „Interaction between metabotropic glutamate receptor 7 and alpha tubulin”. J. Neurochem. 80 (6): 980–8. DOI:10.1046/j.0022-3042.2002.00778.x. PMC 2925652. PMID 11953448. 
  • Schulz HL, Stohr H, Weber BH (2002). „Characterization of three novel isoforms of the metabotrobic glutamate receptor 7 (GRM7)”. Neurosci. Lett. 326 (1): 37–40. DOI:10.1016/S0304-3940(02)00306-3. PMID 12052533. 
  • Ota T, Suzuki Y, Nishikawa T i dr.. (2004). „Complete sequencing and characterization of 21,243 full-length human cDNAs”. Nat. Genet. 36 (1): 40–5. DOI:10.1038/ng1285. PMID 14702039. 
  • Kobayashi Y, Akiyoshi J, Kanehisa M i dr.. (2007). „Lack of polymorphism in genes encoding mGluR 7, mGluR 8, GABA(A) receptor alfa-6 subunit and nociceptin/orphanin FQ receptor and panic disorder”. Psychiatr. Genet. 17 (1): 9. DOI:10.1097/YPG.0b013e32801118bc. PMID 17167337. 

Spoljašnje veze

  • „Metabotropic Glutamate Receptors: mGlu7”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-03. 
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PDB Galerija
2e4z: Kristalna struktura regiona sa vezanim ligandom grupe III metabotropnog glutamatnog receptora
2e4z: Kristalna struktura regiona sa vezanim ligandom grupe III metabotropnog glutamatnog receptora  
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  • u
Klasa A: Rodopsinu slični
α1 (A, B, D) • α2 (A, B, C) • β1 • β2 • β3
Adenozinski (A1, A2A, A2B, A3) • P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
(svi osim 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7)
Drugi
Acetilholin (M1, M2, M3, M4, M5) • Dopamin (D1, D2, D3, D4, D5) • Histamin (H1, H2, H3, H4) • Melatonin (1A, 1B, 1C) • TAAR (1, 2, 3, 5, 6, 8, 9)
Metaboliti i
signalni molekuli
CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) • Prostaciklin • Tromboksan
Drugi
Žučna kiselina • Kanabinoidni (CB1, CB2, GPR (18, 55, 119)) • EBI2 • Estrogen • Slobodna masna kiselina (1, 2, 3, 4) • Laktat  • Lizofosfatidna kiselina (1, 2, 3, 4, 5, 6)  • Lizofosfolipid (1, 2, 3, 4, 5, 6, 7, 8) • Niacin (1, 2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1, 2, 3, 4, 5) • Sukcinat
Peptid
B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5) • Neuromedin (B, U (1, 2)) • Neurotenzin (1, 2)
Drugi
Anafilatoksin (C3a, C5a) • Angiotenzin (1, 2) • Apelin • Bombezin (BRS3, GRPR, NMBR) • Bradikinin (B1, B2) • Hemokin • Holecistokinin (A, B) • Endotelin (A, B) • Formil peptid (1, 2, 3) • FSH • Galanin (1, 2, 3) • GHB receptor • Gonadotropin-oslobađajući hormon (1, 2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) • Melanokortin (1, 2, 3, 4, 5) • MCHR (1, 2) • Motilin • Opioidni (δ, κ, μ, Nociceptin & ζ, ali ne σ) • Oreksin (1, 2) • Oksitocin • Prokineticin (1, 2) • Prolaktin-oslobađajući peptid • Relaksin (1, 2, 3, 4) • Somatostatin (1, 2, 3, 4, 5) • Tahikinin (1, 2, 3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A, 1B, 2)
Razno
GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Drugi
Adrenomedulin • Mirisni • Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Proteazom-aktivirani (1, 2, 3, 4) • SREB (1, 2, 3)
Klasa B: Sekretinu slični
GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Drugi
Klasa C: Metabotropni
glutamat / feromon
TAS1R (1, 2, 3) • TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Drugi
Klasa F:
Frizzled / Zaglađeni
Uvojiti
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Zaglađeni
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)