GPR34

edit
G protein-spregnuti receptor 34
Identifikatori
SimboliGPR34;
Vanjski IDOMIM: 300241 MGI: 1346334 HomoloGene: 36174 IUPHAR: GPR34 GeneCards: GPR34 Gene
Ontologija gena
Molekularna funkcija • aktivnost rodopsinu sličnog receptora
• receptorska aktivnost
• aktivnost purinergičkog nukleotidnog receptora, G-protein spregnutog
Celularna komponenta • integralno sa ćelijskom membranom
• membrana
Biološki proces • prenos signala
• signalni put G-protein spregnutog receptora
Ortolozi
VrstaČovekMiš
Entrez285723890
EnsemblENSG00000171659ENSMUSG00000040229
UniProtQ9UPC5Q3USC5
RefSeq (mRNA)NM_001033513NM_011823
RefSeq (protein)NP_001028685NP_035953
Lokacija (UCSC)Chr X:
41.43 - 41.44 Mb		Chr X:
12.79 - 12.8 Mb
PubMed pretraga[1][2]

GPR34, G protein-spregnuti receptor 34, je protein koji je kod čoveka kodiran GPR34 genom.[1][2][3]

G protein-spregnuti receptori, kao što je GPR34, su integralni membranski proteini koji sadrže 7 transmembranskih domaina (TM). Ti proteini prenose signale u unutrašnjost ćelije putem aktivacije heterotrimernih G proteina koji zatim aktiviraju razne efektorske proteine, što ultimatno dovodi do fiziološkog responsa.[3]

Literatura

  1. ↑ Schoneberg T, Schulz A, Grosse R, Schade R, Henklein P, Schultz G, Gudermann T (Aug 1999). „A novel subgroup of class I G-protein-coupled receptors”. Biochim Biophys Acta 1446 (1-2): 57–70. PMID 10395919. 
  2. ↑ Marchese A, Sawzdargo M, Nguyen T, Cheng R, Heng HH, Nowak T, Im DS, Lynch KR, George SR, O'dowd BF (May 1999). „Discovery of three novel orphan G-protein-coupled receptors”. Genomics 56 (1): 12–21. DOI:10.1006/geno.1998.5655. PMID 10036181. 
  3. ↑ 3,0 3,1 „Entrez Gene: GPR34 G protein-coupled receptor 34”. 

Dodatna literatura

  • Hillier LD, Lennon G, Becker M, et al. (1997). „Generation and analysis of 280,000 human expressed sequence tags.”. Genome Res. 6 (9): 807–28. DOI:10.1101/gr.6.9.807. PMID 8889549. 
  • Jacobi FK, Broghammer M, Pesch K, et al. (2000). „Physical mapping and exclusion of GPR34 as the causative gene for congenital stationary night blindness type 1.”. Hum. Genet. 107 (1): 89–91. DOI:10.1007/s004390050017. PMID 10982042. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). „Complete sequencing and characterization of 21,243 full-length human cDNAs.”. Nat. Genet. 36 (1): 40–5. DOI:10.1038/ng1285. PMID 14702039. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
  • Otsuki T, Ota T, Nishikawa T, et al. (2007). „Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.”. DNA Res. 12 (2): 117–26. DOI:10.1093/dnares/12.2.117. PMID 16303743. 
  • Engemaier E, Römpler H, Schöneberg T, Schulz A (2006). „Genomic and supragenomic structure of the nucleotide-like G-protein-coupled receptor GPR34.”. Genomics 87 (2): 254–64. DOI:10.1016/j.ygeno.2005.10.001. PMID 16338117. 
  • Oh JH, Yang JO, Hahn Y, et al. (2006). „Transcriptome analysis of human gastric cancer.”. Mamm. Genome 16 (12): 942–54. DOI:10.1007/s00335-005-0075-2. PMID 16341674. 
  • p
  • r
  • u
Klasa A: Rodopsinu slični
α1 (A, B, D) • α2 (A, B, C) • β1 • β2 • β3
Adenozinski (A1, A2A, A2B, A3) • P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
(svi osim 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7)
Drugi
Acetilholin (M1, M2, M3, M4, M5) • Dopamin (D1, D2, D3, D4, D5) • Histamin (H1, H2, H3, H4) • Melatonin (1A, 1B, 1C) • TAAR (1, 2, 3, 5, 6, 8, 9)
Metaboliti i
signalni molekuli
CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) • Prostaciklin • Tromboksan
Drugi
Žučna kiselina • Kanabinoidni (CB1, CB2, GPR (18, 55, 119)) • EBI2 • Estrogen • Slobodna masna kiselina (1, 2, 3, 4) • Laktat  • Lizofosfatidna kiselina (1, 2, 3, 4, 5, 6)  • Lizofosfolipid (1, 2, 3, 4, 5, 6, 7, 8) • Niacin (1, 2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1, 2, 3, 4, 5) • Sukcinat
Peptid
B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5) • Neuromedin (B, U (1, 2)) • Neurotenzin (1, 2)
Drugi
Anafilatoksin (C3a, C5a) • Angiotenzin (1, 2) • Apelin • Bombezin (BRS3, GRPR, NMBR) • Bradikinin (B1, B2) • Hemokin • Holecistokinin (A, B) • Endotelin (A, B) • Formil peptid (1, 2, 3) • FSH • Galanin (1, 2, 3) • GHB receptor • Gonadotropin-oslobađajući hormon (1, 2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) • Melanokortin (1, 2, 3, 4, 5) • MCHR (1, 2) • Motilin • Opioidni (δ, κ, μ, Nociceptin & ζ, ali ne σ) • Oreksin (1, 2) • Oksitocin • Prokineticin (1, 2) • Prolaktin-oslobađajući peptid • Relaksin (1, 2, 3, 4) • Somatostatin (1, 2, 3, 4, 5) • Tahikinin (1, 2, 3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A, 1B, 2)
Razno
GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Drugi
Adrenomedulin • Mirisni • Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Proteazom-aktivirani (1, 2, 3, 4) • SREB (1, 2, 3)
Klasa B: Sekretinu slični
GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Drugi
Klasa C: Metabotropni
glutamat / feromon
TAS1R (1, 2, 3) • TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Drugi
Klasa F:
Frizzled / Zaglađeni
Uvojiti
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Zaglađeni
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)