FZD4

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Uvojiti receptor 4
Identifikatori
SimboliFZD4; CD344; EVR1; FEVR; FZD4S; Fz-4; FzE4
Vanjski IDOMIM: 604579 MGI: 108520 HomoloGene: 7325 IUPHAR: FZD4 GeneCards: FZD4 Gene
Ontologija gena
Molekularna funkcija • aktivnost G protein spregnutog receptora
• receptorsko vezivanje
• proteinsko vezivanje
• Wnt proteinsko vezivanje
• vezivanje PDZ domena
Celularna komponenta • citoplazma
• ćelijska površina
• integralno sa membranom
• sinaptosom
• membrana neuronske projekcije
Biološki proces • pozitivna regulacija proteinske fosforilacije
• razvoj vaskulature
• morfogeneza odlivnog trakta
• signalni put G protein spregnutog receptora spregnutog sa cGMP nukleotidom
Pregled RNK izražavanja
podaci
Ortolozi
VrstaČovekMiš
Entrez832214366
EnsemblENSG00000174804ENSMUSG00000049791
UniProtQ9ULV1Q61088
RefSeq (mRNA)NM_012193.3NM_008055.4
RefSeq (protein)NP_036325.2NP_032081.3
Lokacija (UCSC)Chr 11:
86.66 - 86.67 Mb		Chr 7:
96.55 - 96.56 Mb
PubMed pretraga[1][2]

Uvojiti-4 je protein koji je kod ljudi kodiran FZD4 genom.[1][2][3] FZD4 je takođe označen sa CD344 (klaster diferencijacije 344).

Članovi familije „uvojitih“ proteina su 7-transmembranski receptori za Wnt signalne proteine. FZD4 protein sadrži signalni peptid, cisteinom bogati domen u N-terminalnom ekstracelularnom regionu, 7 transmembranski domen, i C-terminalni PDZ vezujući motiv. Uvojiti-4 je jedini predstavnik family „frizzeled“ receptora koji se potentno vezuje za ligand norin. Taj ligand je funkcionalno sličan sa strukturno različitim Wingless tipom proteina. FZD4 signalizacija indukovana norinom reguliše vaskularni razvoj retine kičmenjaka i kontroliše krvne sudove uva. Većina uvojitih receptora je spregnuta sa beta-kateninskim kanoničkim signalnim putem. Ovaj protein potencijalno učestvuje kao pozitivni regulator signalnog puta Wingless tipa MMTV mesta integracije.[3]

Reference

  1. ↑ Kirikoshi H, Sagara N, Koike J, Tanaka K, Sekihara H, Hirai M, Katoh M (Dec 1999). „Molecular cloning and characterization of human Frizzled-4 on chromosome 11q14-q21”. Biochem Biophys Res Commun 264 (3): 955–61. DOI:10.1006/bbrc.1999.1612. PMID 10544037. 
  2. ↑ Toomes C, Bottomley HM, Jackson RM, Towns KV, Scott S, Mackey DA, Craig JE, Jiang L, Yang Z, Trembath R, Woodruff G, Gregory-Evans CY, Gregory-Evans K, Parker MJ, Black GC, Downey LM, Zhang K, Inglehearn CF (Mar 2004). „Mutations in LRP5 or FZD4 Underlie the Common Familial Exudative Vitreoretinopathy Locus on Chromosome 11q”. Am J Hum Genet 74 (4): 721–30. DOI:10.1086/383202. PMC 1181948. PMID 15024691. 
  3. ↑ 3,0 3,1 „Entrez Gene: FZD4 frizzled homolog 4 (Drosophila)”. 

Literatura

  • Li Y, Fuhrmann C, Schwinger E i dr.. (1992). „The gene for autosomal dominant familial exudative vitreoretinopathy (Criswick-Schepens) on the long arm of chromosome 11”. Am. J. Ophthalmol. 113 (6): 712–3. PMID 1598965. 
  • Tanaka S, Akiyoshi T, Mori M i dr.. (1998). „A novel frizzled gene identified in human esophageal carcinoma mediates APC/β-catenin signals”. Proc. Natl. Acad. Sci. U.S.A. 95 (17): 10164–9. DOI:10.1073/pnas.95.17.10164. PMC 21479. PMID 9707618. 
  • Sagara N, Kirikoshi H, Terasaki H i dr.. (2001). „FZD4S, a splicing variant of frizzled-4, encodes a soluble-type positive regulator of the WNT signaling pathway”. Biochem. Biophys. Res. Commun. 282 (3): 750–6. DOI:10.1006/bbrc.2001.4634. PMID 11401527. 
  • Takeda S, Kadowaki S, Haga T i dr.. (2002). „Identification of G protein-coupled receptor genes from the human genome sequence”. FEBS Lett. 520 (1–3): 97–101. DOI:10.1016/S0014-5793(02)02775-8. PMID 12044878. 
  • Hering H, Sheng M (2002). „Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95”. FEBS Lett. 521 (1–3): 185–9. DOI:10.1016/S0014-5793(02)02831-4. PMID 12067714. 
  • Robitaille J, MacDonald ML, Kaykas A i dr.. (2002). „Mutant frizzled-4 disrupts retinal angiogenesis in familial exudative vitreoretinopathy”. Nat. Genet. 32 (2): 326–30. DOI:10.1038/ng957. PMID 12172548. 
  • Strausberg RL, Feingold EA, Grouse LH i dr.. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Chen W, ten Berge D, Brown J i dr.. (2003). „Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4”. Science 301 (5638): 1391–4. DOI:10.1126/science.1082808. PMID 12958364. 
  • Toomes C, Downey LM, Bottomley HM i dr.. (2004). „Identification of a fourth locus (EVR4) for familial exudative vitreoretinopathy (FEVR)”. Mol. Vis. 10: 37–42. PMID 14737064. 
  • Yao R, Natsume Y, Noda T (2005). „MAGI-3 is involved in the regulation of the JNK signaling pathway as a scaffold protein for frizzled and Ltap”. Oncogene 23 (36): 6023–30. DOI:10.1038/sj.onc.1207817. PMID 15195140. 
  • Toomes C, Bottomley HM, Scott S i dr.. (2004). „Spectrum and frequency of FZD4 mutations in familial exudative vitreoretinopathy”. Invest. Ophthalmol. Vis. Sci. 45 (7): 2083–90. DOI:10.1167/iovs.03-1044. PMID 15223780. 
  • Omoto S, Hayashi T, Kitahara K i dr.. (2004). „Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R)”. Ophthalmic Genet. 25 (2): 81–90. DOI:10.1080/13816810490514270. PMID 15370539. 
  • Yoshida S, Arita R, Yoshida A i dr.. (2004). „Novel mutation in FZD4 gene in a Japanese pedigree with familial exudative vitreoretinopathy”. Am. J. Ophthalmol. 138 (4): 670–1. DOI:10.1016/j.ajo.2004.05.001. PMID 15488808. 
  • Gerhard DS, Wagner L, Feingold EA i dr.. (2004). „The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
  • Qin M, Hayashi H, Oshima K i dr.. (2006). „Complexity of the genotype-phenotype correlation in familial exudative vitreoretinopathy with mutations in the LRP5 and/or FZD4 genes”. Hum. Mutat. 26 (2): 104–12. DOI:10.1002/humu.20191. PMID 15981244. 
  • Nallathambi J, Shukla D, Rajendran A i dr.. (2006). „Identification of novel FZD4 mutations in Indian patients with familial exudative vitreoretinopathy”. Mol. Vis. 12: 1086–92. PMID 17093393. 
  • Planutis K, Planutiene M, Moyer MP i dr.. (2007). „Regulation of norrin receptor frizzled-4 by Wnt2 in colon-derived cells”. BMC Cell Biol. 8: 12. DOI:10.1186/1471-2121-8-12. PMC 1847812. PMID 17386109. 

Vidi još

Spoljašnje veze

  • „Frizzled Receptors: FZD4”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-03. ]
  • GeneReviews/NCBI/NIH/UW entry on Familial Exudative Vitreoretinopathy, Autosomal Dominant
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Klasa A: Rodopsinu slični
α1 (A, B, D) • α2 (A, B, C) • β1 • β2 • β3
Adenozinski (A1, A2A, A2B, A3) • P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
(svi osim 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7)
Drugi
Acetilholin (M1, M2, M3, M4, M5) • Dopamin (D1, D2, D3, D4, D5) • Histamin (H1, H2, H3, H4) • Melatonin (1A, 1B, 1C) • TAAR (1, 2, 3, 5, 6, 8, 9)
Metaboliti i
signalni molekuli
CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) • Prostaciklin • Tromboksan
Drugi
Žučna kiselina • Kanabinoidni (CB1, CB2, GPR (18, 55, 119)) • EBI2 • Estrogen • Slobodna masna kiselina (1, 2, 3, 4) • Laktat  • Lizofosfatidna kiselina (1, 2, 3, 4, 5, 6)  • Lizofosfolipid (1, 2, 3, 4, 5, 6, 7, 8) • Niacin (1, 2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1, 2, 3, 4, 5) • Sukcinat
Peptid
B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5) • Neuromedin (B, U (1, 2)) • Neurotenzin (1, 2)
Drugi
Anafilatoksin (C3a, C5a) • Angiotenzin (1, 2) • Apelin • Bombezin (BRS3, GRPR, NMBR) • Bradikinin (B1, B2) • Hemokin • Holecistokinin (A, B) • Endotelin (A, B) • Formil peptid (1, 2, 3) • FSH • Galanin (1, 2, 3) • GHB receptor • Gonadotropin-oslobađajući hormon (1, 2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) • Melanokortin (1, 2, 3, 4, 5) • MCHR (1, 2) • Motilin • Opioidni (δ, κ, μ, Nociceptin & ζ, ali ne σ) • Oreksin (1, 2) • Oksitocin • Prokineticin (1, 2) • Prolaktin-oslobađajući peptid • Relaksin (1, 2, 3, 4) • Somatostatin (1, 2, 3, 4, 5) • Tahikinin (1, 2, 3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A, 1B, 2)
Razno
GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Drugi
Adrenomedulin • Mirisni • Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Proteazom-aktivirani (1, 2, 3, 4) • SREB (1, 2, 3)
Klasa B: Sekretinu slični
GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Drugi
Klasa C: Metabotropni
glutamat / feromon
TAS1R (1, 2, 3) • TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Drugi
Klasa F:
Frizzled / Zaglađeni
Uvojiti
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Zaglađeni
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)
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1-50
CD1 (a-c, 1A, 1D, 1E) • CD2 • CD3 (γ, δ, ε) • CD4 • CD5 • CD6 • CD7 • CD8 (a) • CD9 • CD10 • CD11 (a, b, c) • CD13 • CD14 • CD15 • CD16 (A, B) • CD18 • CD19 • CD20 • CD21 • CD22 • CD23 • CD24 • CD25 • CD26 • CD27 • CD28 • CD29 • CD30 • CD31 • CD32 (A, B) • CD33 • CD34 • CD35 • CD36 • CD37 • CD38 • CD39 • CD40 • CD41 • CD42 (a, b, c, d) • CD43 • CD44 • CD45 • CD46 • CD47 • CD48 • CD49 (a, b, c, d, e, f) • CD50
51-100
CD51 • CD52 • CD53 • CD54 • CD55 • CD56 • CD57 • CD58 • CD59 • CD61 • CD62 (E, L, P) • CD63 • CD64 (A, B, C) • CD66 (a, b, c, d, e, f) • CD68 • CD69 • CD70 • CD71 • CD72 • CD73 • CD74 • CD78 • CD79 (a, b) • CD80 • CD81 • CD82 • CD83 • CD84 • CD85 (a, d, e, h, j, k) • CD86 • CD87 • CD88 • CD89 • CD90 • CD91- CD92 • CD93 • CD94 • CD95 • CD96 • CD97 • CD98 • CD99 • CD100
101-150
CD101 • CD102 • CD103 • CD104 • CD105 • CD106 • CD107 (a, b) • CD108 • CD109 • CD110 • CD111 • CD112 • CD113 • CD114 • CD115 • CD116 • CD117 • CD118 • CD119 • CD120 (a, b) • CD121 (a, b) • CD122 • CD123 • CD124 • CD125 • CD126 • CD127 • CD129 • CD130 • CD131 • CD132 • CD133 • CD134 • CD135 • CD136 • CD137 • CD138 • CD140b • CD141 • CD142 • CD143 • CD144 • CD146 • CD147 • CD148 • CD150
151-200
CD151 • CD152 • CD153 • CD154 • CD155 • CD156 (a, b, c) • CD157 • CD158 (a, d, e, i, k) • CD159 (a, c) • CD160 • CD161 • CD162 • CD163 • CD164 • CD166 • CD167 (a, b) • CD168 • CD169 • CD170 • CD171 • CD172 (a, b, g) • CD174 • CD177 • CD178 • CD179 (a, b) • CD181 • CD182 • CD183 • CD184 • CD185 • CD186 • CD191 • CD192 • CD193 • CD194 • CD195 • CD196 • CD197 • CDw198 • CDw199 • CD200
201-250
CD201 • CD202b • CD204 • CD205 • CD206 • CD207 • CD208 • CD209 • CDw210 (a, b) • CD212 • CD213a (1, 2) • CD217 • CD218 (a, b) • CD220 • CD221 • CD222 • CD223 • CD224 • CD225 • CD226 • CD227 • CD228 • CD229 • CD230 • CD233 • CD234 • CD235 (a, b) • CD236 • CD238 • CD239 • CD240CE • CD241 • CD243 • CD244 • CD246 • CD247- CD248 • CD249
251-300
CD252 • CD253 • CD254 • CD256 • CD257 • CD258 • CD261 • CD262 • CD264 • CD265 • CD266 • CD267 • CD268 • CD269 • CD271 • CD272 • CD273 • CD274 • CD275 • CD276 • CD278 • CD279 • CD280 • CD281 • CD282 • CD283 • CD284 • CD286 • CD288 • CD289 • CD290 • CD292 • CDw293 • CD294 • CD295 • CD297 • CD298 • CD299
301-350
CD300A • CD301 • CD302 • CD303 • CD304 • CD305 • CD306 • CD307 • CD309 • CD312 • CD314 • CD315 • CD316 • CD317 • CD318 • CD320 • CD321 • CD322 • CD324 • CD325 • CD326 • CD328 • CD329 • CD331 • CD332 • CD333 • CD334 • CD335 • CD336 • CD337 • CD338 • CD339 • CD340 • CD344 • CD349 • CD350