TAS2R14

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Receptor ukusa tip 2 član 14
Identifikatori
SimboliTAS2R14; T2R14; TRB1
Vanjski IDOMIM: 604790 MGI: 2681298 HomoloGene: 87013 IUPHAR: GeneCards: TAS2R14 Gene
Ontologija gena
Molekularna funkcija • aktivnost receptora ukusa
Celularna komponenta • integralno sa membranom
Biološki proces • signalni put G-protein spregnutog receptora
• hemosensorno ponašanje
• detekcija hemijskog stimulusa koji učestvuje u senzornoj percepciji ukusa
Ortolozi
VrstaČovekMiš
Entrez50840387616
EnsemblENSG00000212127ENSMUSG00000071147
UniProtQ9NYV8Q7TQA4
RefSeq (mRNA)NM_023922.1NM_021562.1
RefSeq (protein)NP_076411.1NP_067537.1
Lokacija (UCSC)Chr 12:
11.09 - 11.32 Mb		Chr 6:
133 - 133.01 Mb
PubMed pretraga[1][2]

Receptor ukusa tip 2 član 14 je protein koji je kod ljudi kodiran TAS2R14 genom.[1][2][3]

Funkcije

Ovaj protein je član familije of mogućih receptora ukusa. On pripada grupi G protein spregnutih receptora i specifično je izražen u ćelijama ukusa jezika i epitela nepci. On deluje kao receptor gorkog ukusa. Istraživanja funkcionalne ekspresije su pokazala da TAS2R14 proizvodi respons na (-)-α-tujon, primarni neurotoksični agens u absintu, i pikrotoksinu, otrovu prisutnom u bobicama biljke Anamirta cocculus.[4] Ovaj gen se nalazi u genskom klasteru na hromozomu 12p13.[3]

Reference

  1. ↑ Adler E, Hoon MA, Mueller KL, Chandrashekar J, Ryba NJ, Zuker CS (Apr 2000). „A novel family of mammalian taste receptors”. Cell 100 (6): 693–702. DOI:10.1016/S0092-8674(00)80705-9. PMID 10761934. 
  2. ↑ Matsunami H, Montmayeur JP, Buck LB (Apr 2000). „A family of candidate taste receptors in human and mouse”. Nature 404 (6778): 601–4. DOI:10.1038/35007072. PMID 10766242. 
  3. ↑ 3,0 3,1 „Entrez Gene: TAS2R14 taste receptor, type 2, member 14”. 
  4. ↑ Behrens, M., A. Brockhoff, C. Kuhn, B. Bufe, M. Winnig, and W. Meyerhof (2004). „The human taste receptor hTAS2R14 responds to a variety of different bitter compounds”. Biochem Biophys Res Commun 319 (2): 479–485. DOI:10.1016/j.bbrc.2004.05.019. PMID 15178431. 

Literatura

  • Kinnamon SC (2000). „A plethora of taste receptors”. Neuron 25 (3): 507–10. DOI:10.1016/S0896-6273(00)81054-5. PMID 10774719. 
  • Margolskee RF (2002). „Molecular mechanisms of bitter and sweet taste transduction”. J. Biol. Chem. 277 (1): 1–4. DOI:10.1074/jbc.R100054200. PMID 11696554. 
  • Montmayeur JP, Matsunami H (2002). „Receptors for bitter and sweet taste”. Curr. Opin. Neurobiol. 12 (4): 366–71. DOI:10.1016/S0959-4388(02)00345-8. PMID 12139982. 
  • Chandrashekar J, Mueller KL, Hoon MA, et al. (2000). „T2Rs function as bitter taste receptors”. Cell 100 (6): 703–11. DOI:10.1016/S0092-8674(00)80706-0. PMID 10761935. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Zhang Y, Hoon MA, Chandrashekar J, et al. (2003). „Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways”. Cell 112 (3): 293–301. DOI:10.1016/S0092-8674(03)00071-0. PMID 12581520. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
  • Fischer A, Gilad Y, Man O, Pääbo S (2005). „Evolution of bitter taste receptors in humans and apes”. Mol. Biol. Evol. 22 (3): 432–6. DOI:10.1093/molbev/msi027. PMID 15496549. 
  • Go Y, Satta Y, Takenaka O, Takahata N (2006). „Lineage-Specific Loss of Function of Bitter Taste Receptor Genes in Humans and Nonhuman Primates”. Genetics 170 (1): 313–26. DOI:10.1534/genetics.104.037523. PMC 1449719. PMID 15744053. 
  • Liu T, Qian WJ, Gritsenko MA, et al. (2006). „Human Plasma N-Glycoproteome Analysis by Immunoaffinity Subtraction, Hydrazide Chemistry, and Mass Spectrometry”. J. Proteome Res. 4 (6): 2070–80. DOI:10.1021/pr0502065. PMC 1850943. PMID 16335952. 
  • Behrens M, Bartelt J, Reichling C, et al. (2006). „Members of RTP and REEP gene families influence functional bitter taste receptor expression”. J. Biol. Chem. 281 (29): 20650–9. DOI:10.1074/jbc.M513637200. PMID 16720576. 

Vidi još

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Klasa A: Rodopsinu slični
α1 (A, B, D) • α2 (A, B, C) • β1 • β2 • β3
Adenozinski (A1, A2A, A2B, A3) • P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
(svi osim 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7)
Drugi
Acetilholin (M1, M2, M3, M4, M5) • Dopamin (D1, D2, D3, D4, D5) • Histamin (H1, H2, H3, H4) • Melatonin (1A, 1B, 1C) • TAAR (1, 2, 3, 5, 6, 8, 9)
Metaboliti i
signalni molekuli
CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) • Prostaciklin • Tromboksan
Drugi
Žučna kiselina • Kanabinoidni (CB1, CB2, GPR (18, 55, 119)) • EBI2 • Estrogen • Slobodna masna kiselina (1, 2, 3, 4) • Laktat  • Lizofosfatidna kiselina (1, 2, 3, 4, 5, 6)  • Lizofosfolipid (1, 2, 3, 4, 5, 6, 7, 8) • Niacin (1, 2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1, 2, 3, 4, 5) • Sukcinat
Peptid
B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5) • Neuromedin (B, U (1, 2)) • Neurotenzin (1, 2)
Drugi
Anafilatoksin (C3a, C5a) • Angiotenzin (1, 2) • Apelin • Bombezin (BRS3, GRPR, NMBR) • Bradikinin (B1, B2) • Hemokin • Holecistokinin (A, B) • Endotelin (A, B) • Formil peptid (1, 2, 3) • FSH • Galanin (1, 2, 3) • GHB receptor • Gonadotropin-oslobađajući hormon (1, 2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) • Melanokortin (1, 2, 3, 4, 5) • MCHR (1, 2) • Motilin • Opioidni (δ, κ, μ, Nociceptin & ζ, ali ne σ) • Oreksin (1, 2) • Oksitocin • Prokineticin (1, 2) • Prolaktin-oslobađajući peptid • Relaksin (1, 2, 3, 4) • Somatostatin (1, 2, 3, 4, 5) • Tahikinin (1, 2, 3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A, 1B, 2)
Razno
GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Drugi
Adrenomedulin • Mirisni • Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Proteazom-aktivirani (1, 2, 3, 4) • SREB (1, 2, 3)
Klasa B: Sekretinu slični
GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Drugi
Klasa C: Metabotropni
glutamat / feromon
TAS1R (1, 2, 3) • TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Drugi
Klasa F:
Frizzled / Zaglađeni
Uvojiti
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Zaglađeni
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)