Endotelinski receptor tip B

Identifikatori

EDNRB; ABCDS; ETB; ETRB; HSCR; HSCR2

Vanjski ID

OMIM: 131244 MGI: 102720 HomoloGene: 89 IUPHAR: ET_B GeneCards: EDNRB Gene

Ontologija gena
Molekularna funkcija	• aktivnost rodopsinu-sličnog receptora • aktivnost endotelin-B receptora • receptorska aktivnost • proteinsko vezivanje
Celularna komponenta	• ćelijska membrana • integralno sa ćelijskom membranom
Biološki proces	• neuralna krest ćelijska migracija • pH regulacija • negativna regulacija adenilat ciklazne aktivnosti • G-protein signalizacija, spregnuta sa IP3 sekundarnim glasnikom (aktivacija fosfolipaze C) • razvoj perifernog nervnog sistema • senzorna percepcija zvuka • regulacija krvnog pritiska • melanocitna diferencijacija • pigmentacija tokom razvoja

Pregled RNK izražavanja

podaci

Ortolozi

Vrsta

Čovek

Miš

Entrez

1910

13618

Ensembl

ENSG00000136160

ENSMUSG00000022122

UniProt

P24530

Q8K1V9

RefSeq (mRNA)

NM_000115

NM_007904

RefSeq (protein)

NP_000106

NP_031930

Lokacija (UCSC)

Chr 13:
77.37 - 77.39 Mb

Chr 14:
102.7 - 102.73 Mb

PubMed pretraga

[1]

[2]

Endotelinski receptor tip B, ili ET_B je protein koji je kod ljudi kodiran EDNRB genom.^[1]

Funkcija

Endotelinski receptor tip B je G protein spregnuti receptor koji aktivira sistem fosfatidilinozitol-kalcijumskih sekundarnih glasnika. Njegov ligand, endotelin, se sastoji od familije sa tri potentna vazoaktivna peptida: ET₁, ET₂, i ET₃. Splajsna varijanta, imenovana SVR, je poznata; sekvenca ETB-SVR receptora je identična sa ETRB izuzev intracelularnog C-terminalnog domena. Dok obe splajsne varijante vezuju ET₁, one imaju različite response nakon vezivana, što sugerira da one različito funkcionišu.^[2]

Literatura

^ Cyr C, Huebner K, Druck T, Kris R (1991). „Cloning and chromosomal localization of a human endothelin ETA receptor”. Biochem. Biophys. Res. Commun. 181 (1): 184—90. PMID 1659806. doi:10.1016/S0006-291X(05)81399-3.
^ „Entrez Gene: EDNRB endothelin receptor type B”.

Dodatna literatura

Hofstra RM, Osinga J, Buys CH (1998). „Mutations in Hirschsprung disease: when does a mutation contribute to the phenotype.”. Eur. J. Hum. Genet. 5 (4): 180—5. PMID 9359036.
Haendler B, Hechler U, Schleuning WD (1993). „Molecular cloning of human endothelin (ET) receptors ETA and ETB.”. J. Cardiovasc. Pharmacol. 20 Suppl 12: S1—4. PMID 1282938.
Arai H; Nakao K; Hosoda K (1993). „[Molecular cloning of human endothelin receptors and their expression in vascular endothelial cells and smooth muscle cells]”. Jpn. Circ. J. 56 Suppl 5: 1303—7. PMID 1291713.
Ogawa Y; Nakao K; Arai H (1991). „Molecular cloning of a non-isopeptide-selective human endothelin receptor.”. Biochem. Biophys. Res. Commun. 178 (1): 248—55. PMID 1648908. doi:10.1016/0006-291X(91)91806-N.
Cyr C, Huebner K, Druck T, Kris R (1992). „Cloning and chromosomal localization of a human endothelin ETA receptor.”. Biochem. Biophys. Res. Commun. 181 (1): 184—90. PMID 1659806. doi:10.1016/S0006-291X(05)81399-3.
Nakamuta M; Takayanagi R; Sakai Y (1991). „Cloning and sequence analysis of a cDNA encoding human non-selective type of endothelin receptor.”. Biochem. Biophys. Res. Commun. 177 (1): 34—9. PMID 1710450. doi:10.1016/0006-291X(91)91944-8.
Sakamoto A; Yanagisawa M; Sakurai T (1991). „Cloning and functional expression of human cDNA for the ETB endothelin receptor.”. Biochem. Biophys. Res. Commun. 178 (2): 656—63. PMID 1713452. doi:10.1016/0006-291X(91)90158-4.
Vane J (1991). „Endothelins come home to roost.”. Nature. 348 (6303): 673. PMID 2175394. doi:10.1038/348673a0.
Puffenberger EG; Kauffman ER; Bolk S (1995). „Identity-by-descent and association mapping of a recessive gene for Hirschsprung disease on human chromosome 13q22.”. Hum. Mol. Genet. 3 (8): 1217—25. PMID 7987295. doi:10.1093/hmg/3.8.1217.
Puffenberger EG; Hosoda K; Washington SS (1995). „A missense mutation of the endothelin-B receptor gene in multigenic Hirschsprung's disease.”. Cell. 79 (7): 1257—66. PMID 8001158. doi:10.1016/0092-8674(94)90016-7.
Baynash AG; Hosoda K; Giaid A (1995). „Interaction of endothelin-3 with endothelin-B receptor is essential for development of epidermal melanocytes and enteric neurons.”. Cell. 79 (7): 1277—85. PMID 8001160. doi:10.1016/0092-8674(94)90018-3.
Arai H; Nakao K; Takaya K (1993). „The human endothelin-B receptor gene. Structural organization and chromosomal assignment.”. J. Biol. Chem. 268 (5): 3463—70. PMID 8429023.
Elshourbagy NA; Korman DR; Wu HL (1993). „Molecular characterization and regulation of the human endothelin receptors.”. J. Biol. Chem. 268 (6): 3873—9. PMID 8440682.
Hofstra RM; Osinga J; Tan-Sindhunata G (1996). „A homozygous mutation in the endothelin-3 gene associated with a combined Waardenburg type 2 and Hirschsprung phenotype (Shah-Waardenburg syndrome).”. Nat. Genet. 12 (4): 445—7. PMID 8630503. doi:10.1038/ng0496-445.
Attié T; Till M; Pelet A (1996). „Mutation of the endothelin-receptor B gene in Waardenburg-Hirschsprung disease.”. Hum. Mol. Genet. 4 (12): 2407—9. PMID 8634719. doi:10.1093/hmg/4.12.2407.
Elshourbagy NA; Adamou JE; Gagnon AW (1996). „Molecular characterization of a novel human endothelin receptor splice variant.”. J. Biol. Chem. 271 (41): 25300—7. PMID 8810293. doi:10.1074/jbc.271.41.25300.
Kusafuka T, Wang Y, Puri P (1997). „Novel mutations of the endothelin-B receptor gene in isolated patients with Hirschsprung's disease.”. Hum. Mol. Genet. 5 (3): 347—9. PMID 8852658. doi:10.1093/hmg/5.3.347.
Auricchio A, Casari G, Staiano A, Ballabio A (1997). „Endothelin-B receptor mutations in patients with isolated Hirschsprung disease from a non-inbred population.”. Hum. Mol. Genet. 5 (3): 351—4. PMID 8852659. doi:10.1093/hmg/5.3.351.
Amiel J; Attié T; Jan D (1997). „Heterozygous endothelin receptor B (EDNRB) mutations in isolated Hirschsprung disease.”. Hum. Mol. Genet. 5 (3): 355—7. PMID 8852660. doi:10.1093/hmg/5.3.355.
Freedman NJ; Ament AS; Oppermann M (1997). „Phosphorylation and desensitization of human endothelin A and B receptors. Evidence for G protein-coupled receptor kinase specificity.”. J. Biol. Chem. 272 (28): 17734—43. PMID 9211925. doi:10.1074/jbc.272.28.17734.

Spoljašnje veze

„Endothelin Receptors: ET_B”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Архивирано из оригинала 25. 10. 2021. г.

Transmembranski receptor: receptori spregnuti s G proteinom

Klasa A: Rodopsinu slični

Neurotransmiter

Adrenergički	α1 (A, B, D) • α2 (A, B, C) • β1 • β2 • β3
Purinski	Adenozinski (A1, A2A, A2B, A3) • P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
Serotoninski	(svi osim 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7)
Drugi	Acetilholin (M1, M2, M3, M4, M5) • Dopamin (D1, D2, D3, D4, D5) • Histamin (H1, H2, H3, H4) • Melatonin (1A, 1B, 1C) • TAAR (1, 2, 3, 5, 6, 8, 9)

Metaboliti i
signalni molekuli

Eikozanoidni	CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) • Prostaciklin • Tromboksan
Drugi	Žučna kiselina • Kanabinoidni (CB1, CB2, GPR (18, 55, 119)) • EBI2 • Estrogen • Slobodna masna kiselina (1, 2, 3, 4) • Laktat • Lizofosfatidna kiselina (1, 2, 3, 4, 5, 6) • Lizofosfolipid (1, 2, 3, 4, 5, 6, 7, 8) • Niacin (1, 2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1, 2, 3, 4, 5) • Sukcinat

Peptid

Neuropeptidni

B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5) • Neuromedin (B, U (1, 2)) • Neurotenzin (1, 2)

Drugi

Anafilatoksin (C3a, C5a) • Angiotenzin (1, 2) • Apelin • Bombezin (BRS3, GRPR, NMBR) • Bradikinin (B1, B2) • Hemokin • Holecistokinin (A, B) • Endotelin (A, B) • Formil peptid (1, 2, 3) • FSH • Galanin (1, 2, 3) • GHB receptor • Gonadotropin-oslobađajući hormon (1, 2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) • Melanokortin (1, 2, 3, 4, 5) • MCHR (1, 2) • Motilin • Opioidni (δ, κ, μ, Nociceptin & ζ, ali ne σ) • Oreksin (1, 2) • Oksitocin • Prokineticin (1, 2) • Prolaktin-oslobađajući peptid • Relaksin (1, 2, 3, 4) • Somatostatin (1, 2, 3, 4, 5) • Tahikinin (1, 2, 3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A, 1B, 2)

Razno

Orfan	GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Drugi	Adrenomedulin • Mirisni • Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Proteazom-aktivirani (1, 2, 3, 4) • SREB (1, 2, 3)

Klasa B: Sekretinu slični

Orfan	GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Drugi	Moždano specifični angiogenezni inhibitor (1, 2, 3) • Kadherin (1, 2, 3) • Kalcitonin • CALCRL • CD97 • Kortikotropin-oslobađajući hormon (1, 2) • EMR (1, 2, 3) • Glukagon (GR, GIPR, GLP1R, GLP2R) • Hormon rasta • PACAPR1 • GPR • Latrofilin (1, 2, 3, ELTD1) • Metuzalemski protein • Paratiroidni hormon (1, 2) • Sekretin • Vazoaktivni intestinalni peptid (1, 2)

Klasa C: Metabotropni
glutamat / feromon

Ukus	TAS1R (1, 2, 3) • TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Drugi	Kalcijum-detektujući receptor • GABA B (1, 2) • Glutamatni receptor (Metabotropni glutamat (1, 2, 3, 4, 5, 6, 7, 8)) • GPRC6A • GPR (156, 158, 179) • RAIG (1, 2, 3, 4) • VNR (1, 2, 3, 5)