GPR68

G protein-spregnuti receptor 68

Identifikatori

GPR68; MGC111379; OGR1

Vanjski ID

OMIM: 601404 MGI: 2441763 HomoloGene: 2603 IUPHAR: GPR68 GeneCards: GPR68 Gene

Ontologija gena
Molekularna funkcija	• aktivnost rodopsinu sličnog receptora • receptorska aktivnost
Celularna komponenta	• integralno sa ćelijskom membranom • membrana
Biološki proces	• inflamatorni respons • prenos signal • signalni put G-protein spregnutog receptora

Pregled RNK izražavanja

podaci

Ortolozi

Vrsta

Čovek

Miš

Entrez

8111

238377

Ensembl

ENSG00000119714

ENSMUSG00000047415

UniProt

Q15743

Q148P7

RefSeq (mRNA)

NM_003485

NM_175493

RefSeq (protein)

NP_003476

NP_780702

Lokacija (UCSC)

Chr 14:
90.77 - 90.79 Mb

Chr 12:
101.28 - 101.29 Mb

PubMed pretraga

[1]

[2]

GPR68, G protein-spregnuti receptor 68, ili G protein-spregnuti receptor raka jajnika 1, je protein koji je kod čoveka kodiran GPR68 genom.^[1]^[2]

Vidi još

Proton-indicirajući G protein-spregnuti receptori

Literatura

^ Xu Y, Casey G (1996). „Identification of human OGR1, a novel G protein-coupled receptor that maps to chromosome 14”. Genomics. 35 (2): 397—402. PMID 8661159. doi:10.1006/geno.1996.0377.
^ „Entrez Gene: GPR68 G protein-coupled receptor 68”.

Dodatna literatura

Xu Y (2002). „Sphingosylphosphorylcholine and lysophosphatidylcholine: G protein-coupled receptors and receptor-mediated signal transduction.”. Biochim. Biophys. Acta. 1582 (1–3): 81—8. PMID 12069813.
An S, Tsai C, Goetzl EJ (1996). „Cloning, sequencing and tissue distribution of two related G protein-coupled receptor candidates expressed prominently in human lung tissue.”. FEBS Lett. 375 (1–2): 121—4. PMID 7498459. doi:10.1016/0014-5793(95)01196-L.
Bonaldo MF, Lennon G, Soares MB (1997). „Normalization and subtraction: two approaches to facilitate gene discovery.”. Genome Res. 6 (9): 791—806. PMID 8889548. doi:10.1101/gr.6.9.791.
Xu Y; Zhu K; Hong G; et al. (2000). „Sphingosylphosphorylcholine is a ligand for ovarian cancer G-protein-coupled receptor 1.”. Nat. Cell Biol. 2 (5): 261—7. PMID 10806476. doi:10.1038/35010529. CS1 одржавање: Експлицитна употреба et al. (веза)
Strausberg RL; Feingold EA; Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899. CS1 одржавање: Експлицитна употреба et al. (веза)
Ludwig MG; Vanek M; Guerini D; et al. (2003). „Proton-sensing G-protein-coupled receptors.”. Nature. 425 (6953): 93—8. PMID 12955148. doi:10.1038/nature01905. CS1 одржавање: Експлицитна употреба et al. (веза)
Bektas M; Barak LS; Jolly PS; et al. (2003). „The G protein-coupled receptor GPR4 suppresses ERK activation in a ligand-independent manner.”. Biochemistry. 42 (42): 12181—91. PMID 14567679. doi:10.1021/bi035051y. CS1 одржавање: Експлицитна употреба et al. (веза)
Brandenberger R; Wei H; Zhang S; et al. (2005). „Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.”. Nat. Biotechnol. 22 (6): 707—16. PMID 15146197. doi:10.1038/nbt971. CS1 одржавање: Експлицитна употреба et al. (веза)
Gerhard DS; Wagner L; Feingold EA; et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121—7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504. CS1 одржавање: Експлицитна употреба et al. (веза)
Radu CG; Nijagal A; McLaughlin J; et al. (2005). „Differential proton sensitivity of related G protein-coupled receptors T cell death-associated gene 8 and G2A expressed in immune cells.”. Proc. Natl. Acad. Sci. U.S.A. 102 (5): 1632—7. PMC 545089 . PMID 15665078. doi:10.1073/pnas.0409415102. CS1 одржавање: Експлицитна употреба et al. (веза)
Tomura H; Wang JQ; Komachi M; et al. (2005). „Prostaglandin I(2) production and cAMP accumulation in response to acidic extracellular pH through OGR1 in human aortic smooth muscle cells.”. J. Biol. Chem. 280 (41): 34458—64. PMID 16087674. doi:10.1074/jbc.M505287200. CS1 одржавање: Експлицитна употреба et al. (веза)
Singh LS; Berk M; Oates R; et al. (2007). „Ovarian cancer G protein-coupled receptor 1, a new metastasis suppressor gene in prostate cancer.”. J. Natl. Cancer Inst. 99 (17): 1313—27. PMID 17728215. doi:10.1093/jnci/djm107. CS1 одржавање: Експлицитна употреба et al. (веза)

Transmembranski receptor: receptori spregnuti s G proteinom

Klasa A: Rodopsinu slični

Neurotransmiter

Adrenergički	α1 (A, B, D) • α2 (A, B, C) • β1 • β2 • β3
Purinski	Adenozinski (A1, A2A, A2B, A3) • P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
Serotoninski	(svi osim 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7)
Drugi	Acetilholin (M1, M2, M3, M4, M5) • Dopamin (D1, D2, D3, D4, D5) • Histamin (H1, H2, H3, H4) • Melatonin (1A, 1B, 1C) • TAAR (1, 2, 3, 5, 6, 8, 9)

Metaboliti i
signalni molekuli

Eikozanoidni	CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) • Prostaciklin • Tromboksan
Drugi	Žučna kiselina • Kanabinoidni (CB1, CB2, GPR (18, 55, 119)) • EBI2 • Estrogen • Slobodna masna kiselina (1, 2, 3, 4) • Laktat • Lizofosfatidna kiselina (1, 2, 3, 4, 5, 6) • Lizofosfolipid (1, 2, 3, 4, 5, 6, 7, 8) • Niacin (1, 2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1, 2, 3, 4, 5) • Sukcinat

Peptid

Neuropeptidni

B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5) • Neuromedin (B, U (1, 2)) • Neurotenzin (1, 2)

Drugi

Anafilatoksin (C3a, C5a) • Angiotenzin (1, 2) • Apelin • Bombezin (BRS3, GRPR, NMBR) • Bradikinin (B1, B2) • Hemokin • Holecistokinin (A, B) • Endotelin (A, B) • Formil peptid (1, 2, 3) • FSH • Galanin (1, 2, 3) • GHB receptor • Gonadotropin-oslobađajući hormon (1, 2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) • Melanokortin (1, 2, 3, 4, 5) • MCHR (1, 2) • Motilin • Opioidni (δ, κ, μ, Nociceptin & ζ, ali ne σ) • Oreksin (1, 2) • Oksitocin • Prokineticin (1, 2) • Prolaktin-oslobađajući peptid • Relaksin (1, 2, 3, 4) • Somatostatin (1, 2, 3, 4, 5) • Tahikinin (1, 2, 3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A, 1B, 2)

Razno

Orfan	GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Drugi	Adrenomedulin • Mirisni • Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Proteazom-aktivirani (1, 2, 3, 4) • SREB (1, 2, 3)

Klasa B: Sekretinu slični

Orfan	GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Drugi	Moždano specifični angiogenezni inhibitor (1, 2, 3) • Kadherin (1, 2, 3) • Kalcitonin • CALCRL • CD97 • Kortikotropin-oslobađajući hormon (1, 2) • EMR (1, 2, 3) • Glukagon (GR, GIPR, GLP1R, GLP2R) • Hormon rasta • PACAPR1 • GPR • Latrofilin (1, 2, 3, ELTD1) • Metuzalemski protein • Paratiroidni hormon (1, 2) • Sekretin • Vazoaktivni intestinalni peptid (1, 2)

Klasa C: Metabotropni
glutamat / feromon

Ukus	TAS1R (1, 2, 3) • TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Drugi	Kalcijum-detektujući receptor • GABA B (1, 2) • Glutamatni receptor (Metabotropni glutamat (1, 2, 3, 4, 5, 6, 7, 8)) • GPRC6A • GPR (156, 158, 179) • RAIG (1, 2, 3, 4) • VNR (1, 2, 3, 5)