TAS2R38

Receptor ukusa tip 2 član 38

Identifikatori

TAS2R38; PTC; T2R38; T2R61

Vanjski ID

OMIM: 607751 MGI: 2681306 HomoloGene: 47976 IUPHAR: GeneCards: TAS2R38 Gene

Ontologija gena
Molekularna funkcija	• aktivnost receptora ukusa
Celularna komponenta	• integralno sa membranom
Biološki proces	• signalni put G-protein spregnutog receptora

Ortolozi

Vrsta

Čovek

Miš

Entrez

5726

387513

Ensembl

ENSG00000257138

ENSMUSG00000058250

UniProt

P59533

Q7TQA6

RefSeq (mRNA)

NM_176817.4

NM_001001451.1

RefSeq (protein)

NP_789787.4

NP_001001451.1

Lokacija (UCSC)

Chr 7:
141.67 - 141.67 Mb

Chr 6:
40.56 - 40.56 Mb

PubMed pretraga

[1]

[2]

Receptor ukusa tip 2 član 38 je protein koji je kod ljudi kodiran TAS2R38 genom. TAS2R38 je receptor gorkog ukusa. Različiti genotipi ovog receptora utiču na sposobnost prepoznavanja ukusa 6-n-propiltiouracila (PROP)^[1] i feniltiokarbamida (PTC).^[2]^[3] Though it has often been proposed that varying taste receptor genotypes could influence tasting ability, TAS2R38 is one of the only taste receptors shown to have this function.^[4]

Prenos signala

Kao i kod svih TAS2R proteina, TAS2R38 koristi G-protein gustducin kao svoj primarni metod prenosa signala. Jedinice α i βγ su esencijalne za prenos signala ukusa.^[5]

Reference

^ Duffy VB, Davidson AC, Kidd JR, Kidd KK, Speed WC, Pakstis AJ, Reed DR, Snyder DJ, Bartoshuk LM (2004). „Bitter Receptor Gene (TAS2R38), 6-n-Propylthiouracil (PROP) Bitterness and Alcohol Intake”. Alcoholism, clinical and experimental research. 28 (11): 1629—1637. PMC 1397913 . PMID 15547448. doi:10.1097/01.ALC.0000145789.55183.D4.
^ Prodi DA, Drayna D, Forabosco P, Palmas MA, Maestrale GB, Piras D, Pirastu M, Angius A (2004). „Bitter Taste Study in a Sardinian Genetic Isolate Supports the Association of Phenylthiocarbamide Sensitivity to the TAS2R38 Bitter Receptor Gene”. Chemical Senses. 29 (8): 697—702. PMID 15466815. doi:10.1093/chemse/bjh074.
^ Kim UK, Drayna D (2004). „Genetics of individual differences in bitter taste perception: Lessons from the PTC gene”. Clinical Genetics. 67 (4): 275—280. PMID 15733260. doi:10.1111/j.1399-0004.2004.00361.x.
^ Bachmanov AA, Beauchamp GK (2007). „Taste Receptor Genes”. Annual Review of Nutrition. 27: 389—414. PMC 2721271 . PMID 17444812. doi:10.1146/annurev.nutr.26.061505.111329.
^ Margolskee RF (2001). „Molecular Mechanisms of Bitter and Sweet Taste Transduction”. Journal of Biological Chemistry. 277 (1): 1—4. PMID 11696554. doi:10.1074/jbc.R100054200.

Literatura

Montmayeur JP, Matsunami H (2002). „Receptors for bitter and sweet taste”. Curr. Opin. Neurobiol. 12 (4): 366—71. PMID 12139982. doi:10.1016/S0959-4388(02)00345-8.
Anne-Spence M; Falk CT; Neiswanger K; et al. (1984). „Estimating the recombination frequency for the PTC-Kell linkage”. Hum. Genet. 67 (2): 183—6. PMID 6745938. doi:10.1007/BF00272997. CS1 одржавање: Експлицитна употреба et al. (веза)
Bufe B; Hofmann T; Krautwurst D; et al. (2002). „The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides”. Nat. Genet. 32 (3): 397—401. PMID 12379855. doi:10.1038/ng1014. CS1 одржавање: Експлицитна употреба et al. (веза)
Strausberg RL; Feingold EA; Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899. CS1 одржавање: Експлицитна употреба et al. (веза)
Zhang Y; Hoon MA; Chandrashekar J; et al. (2003). „Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways”. Cell. 112 (3): 293—301. PMID 12581520. doi:10.1016/S0092-8674(03)00071-0. CS1 одржавање: Експлицитна употреба et al. (веза)
Conte C; Ebeling M; Marcuz A; et al. (2003). „Identification and characterization of human taste receptor genes belonging to the TAS2R family”. Cytogenet. Genome Res. 98 (1): 45—53. PMID 12584440. doi:10.1159/000068546. CS1 одржавање: Експлицитна употреба et al. (веза)
Scherer SW; Cheung J; MacDonald JR; et al. (2003). „Human Chromosome 7: DNA Sequence and Biology”. Science. 300 (5620): 767—72. PMC 2882961 . PMID 12690205. doi:10.1126/science.1083423. CS1 одржавање: Експлицитна употреба et al. (веза)
Pronin AN, Tang H, Connor J, Keung W (2005). „Identification of ligands for two human bitter T2R receptors”. Chem. Senses. 29 (7): 583—93. PMID 15337684. doi:10.1093/chemse/bjh064.
Gerhard DS; Wagner L; Feingold EA; et al. (2004). „The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121—7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504. CS1 одржавање: Експлицитна употреба et al. (веза)
Fischer A, Gilad Y, Man O, Pääbo S (2005). „Evolution of bitter taste receptors in humans and apes”. Mol. Biol. Evol. 22 (3): 432—6. PMID 15496549. doi:10.1093/molbev/msi027.
Go Y, Satta Y, Takenaka O, Takahata N (2006). „Lineage-Specific Loss of Function of Bitter Taste Receptor Genes in Humans and Nonhuman Primates”. Genetics. 170 (1): 313—26. PMC 1449719 . PMID 15744053. doi:10.1534/genetics.104.037523.

Spoljašnje veze

TAS2R38+protein,+human на US National Library of Medicine Medical Subject Headings (MeSH)
TAS2R38 Gene Card
TAS2R38 OMIM Page

Vidi još

Receptor ukusa

Transmembranski receptor: receptori spregnuti s G proteinom

Klasa A: Rodopsinu slični

Neurotransmiter

Adrenergički	α1 (A, B, D) • α2 (A, B, C) • β1 • β2 • β3
Purinski	Adenozinski (A1, A2A, A2B, A3) • P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
Serotoninski	(svi osim 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7)
Drugi	Acetilholin (M1, M2, M3, M4, M5) • Dopamin (D1, D2, D3, D4, D5) • Histamin (H1, H2, H3, H4) • Melatonin (1A, 1B, 1C) • TAAR (1, 2, 3, 5, 6, 8, 9)

Metaboliti i
signalni molekuli

Eikozanoidni	CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) • Prostaciklin • Tromboksan
Drugi	Žučna kiselina • Kanabinoidni (CB1, CB2, GPR (18, 55, 119)) • EBI2 • Estrogen • Slobodna masna kiselina (1, 2, 3, 4) • Laktat • Lizofosfatidna kiselina (1, 2, 3, 4, 5, 6) • Lizofosfolipid (1, 2, 3, 4, 5, 6, 7, 8) • Niacin (1, 2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1, 2, 3, 4, 5) • Sukcinat

Peptid

Neuropeptidni

B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5) • Neuromedin (B, U (1, 2)) • Neurotenzin (1, 2)

Drugi

Anafilatoksin (C3a, C5a) • Angiotenzin (1, 2) • Apelin • Bombezin (BRS3, GRPR, NMBR) • Bradikinin (B1, B2) • Hemokin • Holecistokinin (A, B) • Endotelin (A, B) • Formil peptid (1, 2, 3) • FSH • Galanin (1, 2, 3) • GHB receptor • Gonadotropin-oslobađajući hormon (1, 2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) • Melanokortin (1, 2, 3, 4, 5) • MCHR (1, 2) • Motilin • Opioidni (δ, κ, μ, Nociceptin & ζ, ali ne σ) • Oreksin (1, 2) • Oksitocin • Prokineticin (1, 2) • Prolaktin-oslobađajući peptid • Relaksin (1, 2, 3, 4) • Somatostatin (1, 2, 3, 4, 5) • Tahikinin (1, 2, 3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A, 1B, 2)

Razno

Orfan	GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Drugi	Adrenomedulin • Mirisni • Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Proteazom-aktivirani (1, 2, 3, 4) • SREB (1, 2, 3)

Klasa B: Sekretinu slični

Orfan	GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Drugi	Moždano specifični angiogenezni inhibitor (1, 2, 3) • Kadherin (1, 2, 3) • Kalcitonin • CALCRL • CD97 • Kortikotropin-oslobađajući hormon (1, 2) • EMR (1, 2, 3) • Glukagon (GR, GIPR, GLP1R, GLP2R) • Hormon rasta • PACAPR1 • GPR • Latrofilin (1, 2, 3, ELTD1) • Metuzalemski protein • Paratiroidni hormon (1, 2) • Sekretin • Vazoaktivni intestinalni peptid (1, 2)

Klasa C: Metabotropni
glutamat / feromon

Ukus	TAS1R (1, 2, 3) • TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Drugi	Kalcijum-detektujući receptor • GABA B (1, 2) • Glutamatni receptor (Metabotropni glutamat (1, 2, 3, 4, 5, 6, 7, 8)) • GPRC6A • GPR (156, 158, 179) • RAIG (1, 2, 3, 4) • VNR (1, 2, 3, 5)