Receptor trombocit aktivirajućeg faktora

Identifikatori

PTAFR; PAFR

Vanjski ID

OMIM: 173393 MGI: 106066 HomoloGene: 20260 IUPHAR: PAF GeneCards: PTAFR Gene

Ontologija gena
Molekularna funkcija	• receptorska aktivnost • aktivnost receptora trombocit aktivirajućeg faktora • fosfolipidno vezivanje
Celularna komponenta	• integralno sa ćelijskom membranom • membrana
Biološki proces	• produkcija citokina • hemotaksa • inflamatorni respons • imunski respons • prenos signala • signalni put G-protein spregnutog receptora • antimikrobni humoralni respons • fosfoinozitid-posredovana signalizacija

Pregled RNK izražavanja

podaci

Ortolozi

Vrsta

Čovek

Miš

Entrez

5724

19204

Ensembl

ENSG00000169403

ENSMUSG00000056529

UniProt

P25105

Q62035

RefSeq (mRNA)

NM_000952

XM_357441

RefSeq (protein)

NP_000943

XP_357441

Lokacija (UCSC)

Chr 1:
28.35 - 28.39 Mb

Chr 4:
131.84 - 131.85 Mb

PubMed pretraga

[1]

[2]

Receptor trombocit aktivirajućeg faktora je G-protein spregnuti receptor koji vezuje trombocit-aktivirajući faktor.^[1]^[2]

PAF receptor manifestuje strukturne karakteristike gena rodopsinske (MIM 180380) familije i vezuje trombocit-aktivirajući faktor (PAF). PAF je fosfolipid (1-0-alkil-2-acetil-sn-glicero-3-fosforilholin) za koji se smatra da posreduje niz patoloških procesa, kao što su alergija, astma, septički šok, arterijska tromboza, i inflamatorni procesi.^[3]

Literatura

^ Seyfried CE, Schweickart VL, Godiska R, Gray PW (1992). „The human platelet-activating factor receptor gene (PTAFR) contains no introns and maps to chromosome 1”. Genomics. 13 (3): 832—4. PMID 1322356. doi:10.1016/0888-7543(92)90162-L.
^ Ishii S, Nagase T, Shimizu T (2002). „Platelet-activating factor receptor”. Prostaglandins Other Lipid Mediat. 68-69: 599—609. PMID 12432946. doi:10.1016/S0090-6980(02)00058-8.
^ „Entrez Gene: PTAFR platelet-activating factor receptor”.

Dodatna literatura

Shukla SD (1992). „Platelet-activating factor receptor and signal transduction mechanisms.”. FASEB J. 6 (6): 2296—301. PMID 1312046.
Sugimoto T; Tsuchimochi H; McGregor CG; et al. (1993). „Molecular cloning and characterization of the platelet-activating factor receptor gene expressed in the human heart.”. Biochem. Biophys. Res. Commun. 189 (2): 617—24. PMID 1281995. doi:10.1016/0006-291X(92)92245-S. CS1 одржавање: Експлицитна употреба et al. (веза)
Seyfried CE, Schweickart VL, Godiska R, Gray PW (1992). „The human platelet-activating factor receptor gene (PTAFR) contains no introns and maps to chromosome 1.”. Genomics. 13 (3): 832—4. PMID 1322356. doi:10.1016/0888-7543(92)90162-L.
Kunz D, Gerard NP, Gerard C (1992). „The human leukocyte platelet-activating factor receptor. cDNA cloning, cell surface expression, and construction of a novel epitope-bearing analog.”. J. Biol. Chem. 267 (13): 9101—6. PMID 1374385.
Ye RD, Prossnitz ER, Zou AH, Cochrane CG (1991). „Characterization of a human cDNA that encodes a functional receptor for platelet activating factor.”. Biochem. Biophys. Res. Commun. 180 (1): 105—11. PMID 1656963. doi:10.1016/S0006-291X(05)81261-6.
Nakamura M; Honda Z; Izumi T; et al. (1991). „Molecular cloning and expression of platelet-activating factor receptor from human leukocytes.”. J. Biol. Chem. 266 (30): 20400—5. PMID 1657923. CS1 одржавање: Експлицитна употреба et al. (веза)
Haslam RJ, Williams KA, Davidson MM (1986). „Receptor-effector coupling in platelets: roles of guanine nucleotides.”. Adv. Exp. Med. Biol. 192: 265—80. PMID 3010668.
Valone FH (1984). „Isolation of a platelet membrane protein which binds the platelet-activating factor 1-0-hexadecyl-2-acetyl-SN-glycero-3-phosphorylcholine.”. Immunology. 52 (1): 169—74. PMC 1454573 . PMID 6325330.
Cundell DR; Gerard NP; Gerard C; et al. (1995). „Streptococcus pneumoniae anchor to activated human cells by the receptor for platelet-activating factor.”. Nature. 377 (6548): 435—8. PMID 7566121. doi:10.1038/377435a0. CS1 одржавање: Експлицитна употреба et al. (веза)
Izumi T; Kishimoto S; Takano T; et al. (1995). „Expression of human platelet-activating factor receptor gene in EoL-1 cells following butyrate-induced differentiation.”. Biochem. J. 305 (Pt 3): 829—35. PMC 1136334 . PMID 7848283. CS1 одржавање: Експлицитна употреба et al. (веза)
Bito H, Honda Z, Nakamura M, Shimizu T (1994). „Cloning, expression and tissue distribution of rat platelet-activating-factor-receptor cDNA.”. Eur. J. Biochem. 221 (1): 211—8. PMID 8168510. doi:10.1111/j.1432-1033.1994.tb18731.x.
Chase PB, Halonen M, Regan JW (1993). „Cloning of a human platelet-activating factor receptor gene: evidence for an intron in the 5'-untranslated region.”. Am. J. Respir. Cell Mol. Biol. 8 (3): 240—4. PMID 8383507.
Mutoh H; Bito H; Minami M; et al. (1993). „Two different promoters direct expression of two distinct forms of mRNAs of human platelet-activating factor receptor.”. FEBS Lett. 322 (2): 129—34. PMID 8387031. doi:10.1016/0014-5793(93)81552-B. CS1 одржавање: Експлицитна употреба et al. (веза)
Nakamura M; Honda Z; Matsumoto T; et al. (1993). „Isolation and properties of platelet-activating factor receptor cDNAs.”. Journal of lipid mediators. 6 (1-3): 163—8. PMID 8395240. CS1 одржавање: Експлицитна употреба et al. (веза)
Kishimoto S; Shimadzu W; Izumi T; et al. (1996). „Regulation by IL-5 of expression of functional platelet-activating factor receptors on human eosinophils.”. J. Immunol. 157 (9): 4126—32. PMID 8892648. CS1 одржавање: Експлицитна употреба et al. (веза)
Chase PB; Yang JM; Thompson FH; et al. (1997). „Regional mapping of the human platelet-activating factor receptor gene (PTAFR) to 1p35→p34.3 by fluorescence in situ hybridization.”. Cytogenet. Cell Genet. 72 (2-3): 205—7. PMID 8978777. doi:10.1159/000134190. CS1 одржавање: Експлицитна употреба et al. (веза)
Le Gouill C, Parent JL, Rola-Pleszczynski M, Stanková J (1997). „Role of the Cys90, Cys95 and Cys173 residues in the structure and function of the human platelet-activating factor receptor.”. FEBS Lett. 402 (2-3): 203—8. PMID 9037196. doi:10.1016/S0014-5793(96)01531-1.
Ahmed A; Dearn S; Shams M; et al. (1998). „Localization, quantification, and activation of platelet-activating factor receptor in human endometrium during the menstrual cycle: PAF stimulates NO, VEGF, and FAKpp125.”. FASEB J. 12 (10): 831—43. PMID 9657523. CS1 одржавање: Експлицитна употреба et al. (веза)
Cargill M; Altshuler D; Ireland J; et al. (1999). „Characterization of single-nucleotide polymorphisms in coding regions of human genes.”. Nat. Genet. 22 (3): 231—8. PMID 10391209. doi:10.1038/10290. CS1 одржавање: Експлицитна употреба et al. (веза)

Spoljašnje veze

„Platelet-Activating Factor Receptor”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Архивирано из оригинала 03. 03. 2016. г.
platelet+activating+factor+receptor на US National Library of Medicine Medical Subject Headings (MeSH)

Transmembranski receptor: receptori spregnuti s G proteinom

Klasa A: Rodopsinu slični

Neurotransmiter

Adrenergički	α1 (A, B, D) • α2 (A, B, C) • β1 • β2 • β3
Purinski	Adenozinski (A1, A2A, A2B, A3) • P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
Serotoninski	(svi osim 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7)
Drugi	Acetilholin (M1, M2, M3, M4, M5) • Dopamin (D1, D2, D3, D4, D5) • Histamin (H1, H2, H3, H4) • Melatonin (1A, 1B, 1C) • TAAR (1, 2, 3, 5, 6, 8, 9)

Metaboliti i
signalni molekuli

Eikozanoidni	CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) • Prostaciklin • Tromboksan
Drugi	Žučna kiselina • Kanabinoidni (CB1, CB2, GPR (18, 55, 119)) • EBI2 • Estrogen • Slobodna masna kiselina (1, 2, 3, 4) • Laktat • Lizofosfatidna kiselina (1, 2, 3, 4, 5, 6) • Lizofosfolipid (1, 2, 3, 4, 5, 6, 7, 8) • Niacin (1, 2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1, 2, 3, 4, 5) • Sukcinat

Peptid

Neuropeptidni

B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5) • Neuromedin (B, U (1, 2)) • Neurotenzin (1, 2)

Drugi

Anafilatoksin (C3a, C5a) • Angiotenzin (1, 2) • Apelin • Bombezin (BRS3, GRPR, NMBR) • Bradikinin (B1, B2) • Hemokin • Holecistokinin (A, B) • Endotelin (A, B) • Formil peptid (1, 2, 3) • FSH • Galanin (1, 2, 3) • GHB receptor • Gonadotropin-oslobađajući hormon (1, 2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) • Melanokortin (1, 2, 3, 4, 5) • MCHR (1, 2) • Motilin • Opioidni (δ, κ, μ, Nociceptin & ζ, ali ne σ) • Oreksin (1, 2) • Oksitocin • Prokineticin (1, 2) • Prolaktin-oslobađajući peptid • Relaksin (1, 2, 3, 4) • Somatostatin (1, 2, 3, 4, 5) • Tahikinin (1, 2, 3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A, 1B, 2)

Razno

Orfan	GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Drugi	Adrenomedulin • Mirisni • Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Proteazom-aktivirani (1, 2, 3, 4) • SREB (1, 2, 3)

Klasa B: Sekretinu slični

Orfan	GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Drugi	Moždano specifični angiogenezni inhibitor (1, 2, 3) • Kadherin (1, 2, 3) • Kalcitonin • CALCRL • CD97 • Kortikotropin-oslobađajući hormon (1, 2) • EMR (1, 2, 3) • Glukagon (GR, GIPR, GLP1R, GLP2R) • Hormon rasta • PACAPR1 • GPR • Latrofilin (1, 2, 3, ELTD1) • Metuzalemski protein • Paratiroidni hormon (1, 2) • Sekretin • Vazoaktivni intestinalni peptid (1, 2)

Klasa C: Metabotropni
glutamat / feromon

Ukus	TAS1R (1, 2, 3) • TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Drugi	Kalcijum-detektujući receptor • GABA B (1, 2) • Glutamatni receptor (Metabotropni glutamat (1, 2, 3, 4, 5, 6, 7, 8)) • GPRC6A • GPR (156, 158, 179) • RAIG (1, 2, 3, 4) • VNR (1, 2, 3, 5)