GABBR1

Receptor 1 gama aminobuterne kiseline B

PDB prikaza baziran na 1srz.

Dostupne strukture

1srz, 1ss2

Identifikatori

Simboli

GABBR1; GABABR1; GABBR1-3; GB1; GPRC3A; dJ271M21.1.1; dJ271M21.1.2

Vanjski ID

OMIM: 603540 MGI: 1860139 HomoloGene: 1132 IUPHAR: GABA_B1 GeneCards: GABBR1 Gene

Ontologija gena
Molekularna funkcija	• aktivnost prenosnika signala • receptorska aktivnost • aktivnost G-protein spregnutog GABA receptora • proteinsko vezivanje • vezivanje transkripcionog faktora
Celularna komponenta	• ekstracelularni region • rastvorna frakcija • citoplazma • membrana endoplazmatičnog retikuluma • mikrozom • ćelijska membrana • integralno sa ćelijskom membranom • sinaptička vezikula • sinaptozom • ćelijski spoj • aksolema • mitohondrijska membrana • neuronsko ćelijsko telo • dendritska osnova • sinapsa • postsinaptička membrana
Biološki proces	• osteoblastna diferencijacija • negativna regulacija aktivnosti adenilat ciklaze • signalni put gama-aminobuterne kiseline • sinaptička transmisija • negativna regulacija ćelijske proliferacije • regulacija glutamatne sekrecije • negativna regulacija sekrecije gama-aminobutirne kiseline • regulacija cAMP biosintetičkog procesa • negativna regulacija sekrecije epinefrina • negativna regulacija sekrecije dopamina • respons na nikotin • respons na etanol • negativna regulacija sinaptičke transmisije • pozitivna regulacija sekrecije hormona rasta

Pregled RNK izražavanja

podaci

Ortolozi

Vrsta

Čovek

Miš

Entrez

2550

54393

Ensembl

ENSG00000204681

ENSMUSG00000024462

UniProt

Q9UBS5

Q9WV18

RefSeq (mRNA)

NM_001470.2

NM_019439.3

RefSeq (protein)

NP_001461.1

NP_062312.3

Lokacija (UCSC)

Chr 6:
29.52 - 29.6 Mb

Chr 17:
37.18 - 37.21 Mb

PubMed pretraga

[1]

[2]

Receptor 1 gama-aminobuterne kiseline B (GABA_B1) je podjedinica G protein spregnutog receptora koja je kodirana GABBR1 genom.

Gama-aminobuterna kiselina (GABA) je inhibitorni neurotransmiter u centralnom nervnom sistemu sisara. GABA deluje na jonotropne GABA(A/C) receptore čime se proizvodi brza sinaptička inhibicija, kao i na metabotropne GABA(B) receptore, čime nastaju dugotrajniji inhibitorni signali. GABA(B) receptor se sastoji od heterodimera sa dva srodna 7-transmembranska receptora, GABA(B) receptor 1 i GABA(B) receptor 2. Gen GABA(B) receptora 1 se nalazi na hromozomu 6p21.3 u regionu HLA klase I, blizo HLA-F gena. Lokusi predispozicije za maltiplu sklerozu, epilepsiju, i šizofreniju su mapirani u ovaj region. Alternativno splajsovanje ovog gena generiše 4 transkriptne varijante.^[1]

Interakcije

Pokazano je da GABBR1 formira interakcije sa ATF4^[2] i GABBR2.^[3]

Reference

^ „Entrez Gene: GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1”.
^ White JH, McIllhinney RA, Wise A, Ciruela F, Chan WY, Emson PC, Billinton A, Marshall FH (2000). „The GABAB receptor interacts directly with the related transcription factors CREB2 and ATFx”. Proc. Natl. Acad. Sci. U.S.A. UNITED STATES. 97 (25): 13967—72. ISSN 0027-8424. PMC 17684 . PMID 11087824. doi:10.1073/pnas.240452197.
^ White JH, Wise A, Main MJ, Green A, Fraser NJ, Disney GH, Barnes AA, Emson P, Foord SM, Marshall FH (1998). „Heterodimerization is required for the formation of a functional GABA(B) receptor”. Nature. ENGLAND. 396 (6712): 679—82. ISSN 0028-0836. PMID 9872316. doi:10.1038/25354.

Literatura

Fraser DD, Mudrick-Donnon LA, MacVicar BA (1994). „Astrocytic GABA receptors.”. Glia. 11 (2): 83—93. PMID 7927650. doi:10.1002/glia.440110203.
Maruyama K, Sugano S (1994). „Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.”. Gene. 138 (1–2): 171—4. PMID 8125298. doi:10.1016/0378-1119(94)90802-8.
Kaupmann K; Huggel K; Heid J; et al. (1997). „Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors”. Nature. 386 (6622): 239—46. PMID 9069281. doi:10.1038/386239a0.
Suzuki Y; Yoshitomo-Nakagawa K; Maruyama K; et al. (1997). „Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library”. Gene. 200 (1–2): 149—56. PMID 9373149. doi:10.1016/S0378-1119(97)00411-3.
Grifa A; Totaro A; Rommens JM; et al. (1998). „GABA (gamma-amino-butyric acid) neurotransmission: identification and fine mapping of the human GABAB receptor gene”. Biochem. Biophys. Res. Commun. 250 (2): 240—5. PMID 9753614. doi:10.1006/bbrc.1998.9296.
Goei VL; Choi J; Ahn J; et al. (1999). „Human gamma-aminobutyric acid B receptor gene: complementary DNA cloning, expression, chromosomal location, and genomic organization”. Biol. Psychiatry. 44 (8): 659—66. PMID 9798068. doi:10.1016/S0006-3223(98)00244-3.
Kaupmann K; Schuler V; Mosbacher J; et al. (1999). „Human gamma-aminobutyric acid type B receptors are differentially expressed and regulate inwardly rectifying K+ channels”. Proc. Natl. Acad. Sci. U.S.A. 95 (25): 14991—6. PMC 24563 . PMID 9844003. doi:10.1073/pnas.95.25.14991.
White JH; Wise A; Main MJ; et al. (1999). „Heterodimerization is required for the formation of a functional GABA(B) receptor”. Nature. 396 (6712): 679—82. PMID 9872316. doi:10.1038/25354.
Kuner R; Köhr G; Grünewald S; et al. (1999). „Role of heteromer formation in GABAB receptor function”. Science. 283 (5398): 74—7. PMID 9872744. doi:10.1126/science.283.5398.74.
Makoff A (1999). „Molecular cloning of human GABABR1 and its tissue distribution”. Brain Res. Mol. Brain Res. 64 (1): 137—40. PMID 9889352. doi:10.1016/S0169-328X(98)00316-7.
Peters HC; Kämmer G; Volz A; et al. (2000). „Mapping, genomic structure, and polymorphisms of the human GABABR1 receptor gene: evaluation of its involvement in idiopathic generalized epilepsy”. Neurogenetics. 2 (1): 47—54. PMID 9933300. doi:10.1007/s100480050051.
Ng GY; Clark J; Coulombe N; et al. (1999). „Identification of a GABAB receptor subunit, gb2, required for functional GABAB receptor activity”. J. Biol. Chem. 274 (12): 7607—10. PMID 10075644. doi:10.1074/jbc.274.12.7607.
Sander T; Peters C; Kämmer G; et al. (1999). „Association analysis of exonic variants of the gene encoding the GABAB receptor and idiopathic generalized epilepsy”. Am. J. Med. Genet. 88 (4): 305—10. PMID 10402495. doi:10.1002/(SICI)1096-8628(19990820)88:4<305::AID-AJMG5>3.0.CO;2-X.
Wise A; Green A; Main MJ; et al. (1999). „Calcium sensing properties of the GABA(B) receptor”. Neuropharmacology. 38 (11): 1647—56. PMID 10587080. doi:10.1016/S0028-3908(99)00119-7.
Sullivan R; Chateauneuf A; Coulombe N; et al. (2000). „Coexpression of full-length gamma-aminobutyric acid(B) (GABA(B)) receptors with truncated receptors and metabotropic glutamate receptor 4 supports the GABA(B) heterodimer as the functional receptor”. J. Pharmacol. Exp. Ther. 293 (2): 460—7. PMID 10773016.
Schwarz DA; Barry G; Eliasof SD; et al. (2000). „Characterization of gamma-aminobutyric acid receptor GABAB(1e), a GABAB(1) splice variant encoding a truncated receptor”. J. Biol. Chem. 275 (41): 32174—81. PMID 10906333. doi:10.1074/jbc.M005333200.
White JH; McIllhinney RA; Wise A; et al. (2001). „The GABAB receptor interacts directly with the related transcription factors CREB2 and ATFx”. Proc. Natl. Acad. Sci. U.S.A. 97 (25): 13967—72. PMC 17684 . PMID 11087824. doi:10.1073/pnas.240452197.
Couve A; Kittler JT; Uren JM; et al. (2001). „Association of GABA(B) receptors and members of the 14-3-3 family of signaling proteins”. Mol. Cell. Neurosci. 17 (2): 317—28. PMID 11178869. doi:10.1006/mcne.2000.0938.
Muñoz A, Arellano JI, DeFelipe J (2002). „GABABR1 receptor protein expression in human mesial temporal cortex: changes in temporal lobe epilepsy”. J. Comp. Neurol. 449 (2): 166—79. PMID 12115687. doi:10.1002/cne.10287.

Vidi još

GABAB receptor

Spoljašnje veze

„GABA_B Receptors: GABA_B1”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Архивирано из оригинала 03. 03. 2016. г.

PDB Galerija

1srz: Rešenje strukture drugog komplementnog kontrolnog proteinskog (CCP) modula GABA(B)R1a receptora, Pro-119 trans konformer
1ss2: Rešenje strukture drugog komplementnog kontrolnog proteinskog (CCP) modula GABA(B)R1a receptora, Pro-119 cis konformer

Transmembranski receptor: receptori spregnuti s G proteinom

Klasa A: Rodopsinu slični

Neurotransmiter

Adrenergički	α1 (A, B, D) • α2 (A, B, C) • β1 • β2 • β3
Purinski	Adenozinski (A1, A2A, A2B, A3) • P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
Serotoninski	(svi osim 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7)
Drugi	Acetilholin (M1, M2, M3, M4, M5) • Dopamin (D1, D2, D3, D4, D5) • Histamin (H1, H2, H3, H4) • Melatonin (1A, 1B, 1C) • TAAR (1, 2, 3, 5, 6, 8, 9)

Metaboliti i
signalni molekuli

Eikozanoidni	CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) • Prostaciklin • Tromboksan
Drugi	Žučna kiselina • Kanabinoidni (CB1, CB2, GPR (18, 55, 119)) • EBI2 • Estrogen • Slobodna masna kiselina (1, 2, 3, 4) • Laktat • Lizofosfatidna kiselina (1, 2, 3, 4, 5, 6) • Lizofosfolipid (1, 2, 3, 4, 5, 6, 7, 8) • Niacin (1, 2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1, 2, 3, 4, 5) • Sukcinat

Peptid

Neuropeptidni

B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5) • Neuromedin (B, U (1, 2)) • Neurotenzin (1, 2)

Drugi

Anafilatoksin (C3a, C5a) • Angiotenzin (1, 2) • Apelin • Bombezin (BRS3, GRPR, NMBR) • Bradikinin (B1, B2) • Hemokin • Holecistokinin (A, B) • Endotelin (A, B) • Formil peptid (1, 2, 3) • FSH • Galanin (1, 2, 3) • GHB receptor • Gonadotropin-oslobađajući hormon (1, 2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) • Melanokortin (1, 2, 3, 4, 5) • MCHR (1, 2) • Motilin • Opioidni (δ, κ, μ, Nociceptin & ζ, ali ne σ) • Oreksin (1, 2) • Oksitocin • Prokineticin (1, 2) • Prolaktin-oslobađajući peptid • Relaksin (1, 2, 3, 4) • Somatostatin (1, 2, 3, 4, 5) • Tahikinin (1, 2, 3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A, 1B, 2)

Razno

Orfan	GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Drugi	Adrenomedulin • Mirisni • Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Proteazom-aktivirani (1, 2, 3, 4) • SREB (1, 2, 3)

Klasa B: Sekretinu slični

Orfan	GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Drugi	Moždano specifični angiogenezni inhibitor (1, 2, 3) • Kadherin (1, 2, 3) • Kalcitonin • CALCRL • CD97 • Kortikotropin-oslobađajući hormon (1, 2) • EMR (1, 2, 3) • Glukagon (GR, GIPR, GLP1R, GLP2R) • Hormon rasta • PACAPR1 • GPR • Latrofilin (1, 2, 3, ELTD1) • Metuzalemski protein • Paratiroidni hormon (1, 2) • Sekretin • Vazoaktivni intestinalni peptid (1, 2)

Klasa C: Metabotropni
glutamat / feromon

Ukus	TAS1R (1, 2, 3) • TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Drugi	Kalcijum-detektujući receptor • GABA B (1, 2) • Glutamatni receptor (Metabotropni glutamat (1, 2, 3, 4, 5, 6, 7, 8)) • GPRC6A • GPR (156, 158, 179) • RAIG (1, 2, 3, 4) • VNR (1, 2, 3, 5)